ACETYLENEDICARBOXAMIDE
- Product Name
- ACETYLENEDICARBOXAMIDE
- CAS No.
- 543-21-5
- Chemical Name
- ACETYLENEDICARBOXAMIDE
- Synonyms
- Renamycin;Lenamycin;Aquamycin;4-Dioxane-2;2-BUTYNEDIAMIDE;but-2-ynediaMide;ACETYLENEDICARBOXAMIDE;1,2-Ethynedicarboxamide;Acetylendicarbonsaeureamid;acetylenedicarboxylicaciddiamide
- CBNumber
- CB7103786
- Molecular Formula
- C4H4N2O2
- Formula Weight
- 112.09
- MOL File
- 543-21-5.mol
ACETYLENEDICARBOXAMIDE Property
- Melting point:
- 179 °C
- Boiling point:
- 209.98°C (rough estimate)
- Density
- 1.4421 (rough estimate)
- refractive index
- 1.4610 (estimate)
- storage temp.
- Store at -20°C
- solubility
- DMF: 10 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml
- form
- Fine Crystalline Powder
- pka
- 13.01±0.50(Predicted)
- color
- Cream to beige
- EPA Substance Registry System
- 2-Butynediamide (543-21-5)
Safety
- Hazard Codes
- T
- Risk Statements
- 25-21
- Safety Statements
- 45-36/37-28A
- HS Code
- 29241900
- Toxicity
- LD50 i.v. in mice: 11 mg/kg (Suzuki)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 23637
- Product name
- Cellocidin
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 23637
- Product name
- Cellocidin
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $156
- Updated
- 2024/03/01
- Product number
- 23637
- Product name
- Cellocidin
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $340
- Updated
- 2024/03/01
- Product number
- 23637
- Product name
- Cellocidin
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $631
- Updated
- 2024/03/01
- Product number
- C255953
- Product name
- Cellocidin
- Packaging
- 5mg
- Price
- $305
- Updated
- 2021/12/16
ACETYLENEDICARBOXAMIDE Chemical Properties,Usage,Production
Description
Cellocidin is an antibiotic originally isolated from S. chibaensis. It is active against various bacterial strains including M. tuberculosis and against the trypanosomes T. brucei and T. rhodesiense (IC50s = 150 and 30 ng/ml, respectively). It inhibits proliferation of LCL1 and LCL2 cells transformed by Epstein-Barr virus (EBV), activates the c-Myc and NF-κB pathways in BC3 and LCL1 cells, and induces necrotic cell death in B cells infected with gammaherpes virus. Cellocidin (100-200 ppm) is protective against bacterial leaf blight in rice plants and inhibits α-ketoglutarate oxidation in X. oryzae, the bacterium that causes leaf blight, when used at a concentration of 1 ppm, suggesting that it inhibits the citric acid cycle. Formulations containing cellocidin have been used as agricultural pesticides.
Chemical Properties
CREAM TO BEIGE FINE CRYSTALLINE POWDER
Uses
Cellocidin is a small neutral alkyne produced by a number of Streptomyces species, first discovered by Suzuki and colleagues in 1958. Cellocidin has a broad antibacterial, antifungal and antitumor profile due to its ability to react with endogenous thiols like cysteine and glutathione. Cellocidin occurs as a weak active in many bioassays using actinomycete crude extracts and is thus a useful standard for chemical and bioassay dereplication.
Definition
ChEBI: A dicarboxylic acid diamide resulting from the formal condensation of both of the carboxy groups of butynedioic acid with ammonia. An antibacterial agent produced by Streptomyces chibaensis.
Purification Methods
Acetylenedicarboxamide crystallises from MeOH and H2O [m 190-192o(dec) as hemihydrate]. When prepared from the ester + NH3 it has m 213o(dec). Also a melting point of 290-292o(dec) has been reported. [Saggimo J Org Chem 22 1171 1857, Kharash et al. J Org Chem 10 392 1945, Blomquist & Winslow J Org Chem 10 156 1945, Beilstein 2 I 317, 2 III 1995, 2 IV 2295.]
ACETYLENEDICARBOXAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
ACETYLENEDICARBOXAMIDE Suppliers
- Tel
- 021-61259108 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15839
- Advantage
- 69
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 9387
- Advantage
- 52
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17770
- Advantage
- 75
- Tel
- 021-58930698 15921516558
- Fax
- 86-021-58933679
- zhangyichao84@126.com
- Country
- China
- ProdList
- 916
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- 86-(0)29-85992781 17792393971
- info@lynnchem.com
- Country
- China
- ProdList
- 4587
- Advantage
- 58
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58
- Tel
- 025-58851090 13611564524
- Fax
- (6)02557626880
- lwan@aikonchem.com
- Country
- China
- ProdList
- 15951
- Advantage
- 58