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(R)-1-AMinopropan-2-ylcarbaMic Acid tert-Buty Ester

Product Name
(R)-1-AMinopropan-2-ylcarbaMic Acid tert-Buty Ester
CAS No.
100927-10-4
Chemical Name
(R)-1-AMinopropan-2-ylcarbaMic Acid tert-Buty Ester
Synonyms
(R)-2-N-Boc-propane-1,2-diaMine;(R)-2-(Boc-amino)-1-propanamine;(R)-2-(Boc-aMino)-propanaMine HCl;R-2-N-BOC-propane-1,2-diamine-HCl;(R)-tert-butyl 1-aminopropan-2-ylcarbamate;tert-butyl (R)-1-aMinopropan-2-ylcarbaMate;tert-Butyl (R)-1-aMinopropan-2-ylcarbaMate HCl;tert-butyl N-[(2R)-1-aMinopropan-2-yl]carbaMate;(R)-1-Aminopropan-2-ylcarbamic Acid tert-Buty Ester;tert-butyl N-[(1R)-2-amino-1-methyl-ethyl]carbamate
CBNumber
CB71048936
Molecular Formula
C8H18N2O2
Formula Weight
174.24
MOL File
100927-10-4.mol
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(R)-1-AMinopropan-2-ylcarbaMic Acid tert-Buty Ester Property

Boiling point:
264℃
Density 
0.984
Flash point:
113℃
storage temp. 
2-8°C(protect from light)
pka
12.19±0.46(Predicted)
Appearance
White to off-white Solid
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Safety

HS Code 
2924190090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
A628140
Product name
(R)-1-Aminopropan-2-ylcarbamicAcidtert-ButyEster
Packaging
1g
Price
$1320
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0033070
Product name
(R)-TERT-BUTYL-(1-AMINOPROPAN-2-YL)CARBAMATE
Purity
95.00%
Packaging
250MG
Price
$228.9
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB43420
Product name
(R)-tert-Butyl (1-aminopropan-2-yl)carbamate
Packaging
100mg
Price
$250
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB43420
Product name
(R)-tert-Butyl (1-aminopropan-2-yl)carbamate
Packaging
250mg
Price
$300
Updated
2021/12/16
AK Scientific
Product number
X8533
Product name
(R)-tert-Butyl(1-aminopropan-2-yl)carbamate
Packaging
1g
Price
$317
Updated
2021/12/16
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(R)-1-AMinopropan-2-ylcarbaMic Acid tert-Buty Ester Chemical Properties,Usage,Production

Uses

(R)-1-Aminopropan-2-ylcarbamic Acid tert-Buty Ester is used as an intermediate in the preparation of potent benzothiophene inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK 2).

Synthesis

146610-69-7

100927-10-4

To a stirred solution of tert-butyl (S)-1-azidopropan-2-ylcarbamate (S2-3) (6.0 g, 30 mmol) in ethyl acetate (50.0 mL) was added 10% Pd/C (2.3 g). The reaction mixture was stirred at room temperature under hydrogen atmosphere (1 atm) for 15 hours. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the diatomaceous earth was washed with ethyl acetate. The filtrate was concentrated under reduced pressure to afford tert-butyl N-[(1R)-2-amino-1-methylethyl]carbamate (S2-4) (4.8 g, 92% yield) as a light yellow solid.1H NMR (400 MHz, DMSO-d6) δ 0.95 (d, J = 6.6 Hz, 3H), 1.36 (s, 9H), 2.49 (m, 2H), 3.32 (m, 1H), 6.49 (br s, 1H).

References

[1] Patent: US2016/75720, 2016, A1. Location in patent: Paragraph 0247

(R)-1-AMinopropan-2-ylcarbaMic Acid tert-Buty Ester Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-1-AMinopropan-2-ylcarbaMic Acid tert-Buty Ester Suppliers

Canada 1 China 98 Europe 1 India 1 United Kingdom 2 United States 11 Global 114
CHEMSTEP
Tel
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Fax
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Email
info@chemstep.com
Country
Europe
ProdList
6143
Advantage
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View Lastest Price from (R)-1-AMinopropan-2-ylcarbaMic Acid tert-Buty Ester manufacturers

Career Henan Chemical Co
Product
(R)-1-AMinopropan-2-ylcarbaMic Acid tert-Buty Ester 100927-10-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-31

100927-10-4, (R)-1-AMinopropan-2-ylcarbaMic Acid tert-Buty EsterRelated Search:

S-2-N-BOC-propane-1,2-diamine-HCl (S)-[1-(4-BROMO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER R-1-N-CBZ-propane-1,2-diamine-HCl benzyl 2-aMinopropylcarbaMate (R)-benzyl 2-aMinopropylcarbaMate Carbamic acid, [(1S)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI) 1-Piperazinecarboxylic acid, 3,5-diMethyl-, 1,1-diMethylethyl ester, (3S,5S)- Carbamic acid, (2-amino-1-methylethyl)-, 1,1-dimethylethyl ester (9CI) (R)-tert-butyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan- 2-N-BOC-propane-1,2-diamine-HCl [1-(4-BROMO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER (R)-[1-(4-Bromophenyl)ethyl]carbamic acid tert-butyl ester 3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester (3R,5R)-1-Boc-3,5-diMethylpiperazine S-1-N-CBZ-propane-1,2-diamine-HCl S-2-N-BOC-propane-1,2-diamine hydrochloride

  • Carbamic acid, [(1R)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI)
  • tert-butyl (R)-1-aMinopropan-2-ylcarbaMate
  • (R)-2-N-Boc-propane-1,2-diaMine
  • (R)-tert-butyl 1-aminopropan-2-ylcarbamate
  • R-2-N-BOC-propane-1,2-diamine-HCl
  • (R)-2-(Boc-aMino)-propanaMine HCl
  • tert-butyl N-[(2R)-1-aMinopropan-2-yl]carbaMate
  • tert-Butyl (R)-1-aMinopropan-2-ylcarbaMate HCl
  • tert-butyl (R)-1-aMinopropan-2-ylcarbaMate hydrochloride
  • N-[(1R)-2-Amino-1-methylethyl]carbamic acid tert-butyl ester
  • (R)-1-Aminopropan-2-ylcarbamic Acid tert-Buty Ester
  • (R)-2-(Boc-amino)-1-propanamine
  • tert-butyl N-[(1R)-2-amino-1-methyl-ethyl]carbamate
  • ((R)-2-Amino-1-methyl-ethyl)-carbamic acid tert-butyl ester
  • Carbamic acid, N-[(1R)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester
  • 1,1-Dimethylethyl N-[(1R)-2-amino-1-methylethyl]carbamate
  • N-[(R)-2-Amino-1-methylethyl]-carbamic acid tert-butyl ester
  • 100927-10-4
  • N-BOC