Carbamic acid, (3-hydroxy-2,2-dimethylpropyl)-, 1,1-dimethylethyl ester (9CI)

Product Name: Carbamic acid, (3-hydroxy-2,2-dimethylpropyl)-, 1,1-dimethylethyl ester (9CI)
CAS No.: 184357-44-6
Chemical Name: Carbamic acid, (3-hydroxy-2,2-dimethylpropyl)-, 1,1-dimethylethyl ester (9CI)
Synonyms: 3-(Boc-amino)-2,2-dimethylpropanol;3-(Boc-aMino)-2,2-diMethyl-1-propanol;tert-Butyl (3-hydroxy-2,2-dimethylpropyl);Tert-butyl 3-Hydroxy-2,2-dimethylpropylcarbamate;tert-butyl N-(3-hydroxy-2,2-dimethylpropyl)carbamate - [B21981];Carbamic acid, N-(3-hydroxy-2,2-dimethylpropyl)-, 1,1-dimethylethyl ester;Carbamic acid, (3-hydroxy-2,2-dimethylpropyl)-, 1,1-dimethylethyl ester (9CI)
CBNumber: CB71051844
Molecular Formula: C10H21NO3
Formula Weight: 203.28
MOL File: 184357-44-6.mol

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Carbamic acid, (3-hydroxy-2,2-dimethylpropyl)-, 1,1-dimethylethyl ester (9CI) Property

Boiling point:: 311.0±25.0 °C(Predicted)
Density: 0.998±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 12.67±0.46(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B617993
Product name: 3-(Boc-amino)-2,2-dimethyl-1-propanol
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB154453
Product name: tert-Butyl3-hydroxy-2,2-dimethylpropylcarbamate
Packaging: 5G
Price: $152
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB154453
Product name: tert-Butyl3-hydroxy-2,2-dimethylpropylcarbamate
Packaging: 2g
Price: $76
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0385353
Product name: TERT-BUTYL-3-HYDROXY-2,2-DIMETHYLPROPYLCARBAMATE
Purity: 95.00%
Packaging: 5MG
Price: $503.83
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB154453
Product name: tert-Butyl3-hydroxy-2,2-dimethylpropylcarbamate
Packaging: 25g
Price: $528
Updated: 2021/12/16

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Carbamic acid, (3-hydroxy-2,2-dimethylpropyl)-, 1,1-dimethylethyl ester (9CI) Chemical Properties,Usage,Production

Synthesis

26734-09-8

24424-99-5

184357-44-6

Step 1: Synthesis of tert-butyl (3-hydroxy-2,2-dimethylpropyl) carbamate: 3-amino-2,2-dimethyl-1-propanol (1.50 g, 14.5 mmol) was dissolved in dichloromethane (70 ml) followed by addition of di-tert-butyl dicarbonate (3.49 g, 16.0 mmol). The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, saturated ammonium chloride solution (NH4Cl) was added and stirring was continued for 10 minutes. The organic and aqueous layers were separated, and the organic phase was washed with saturated sodium bicarbonate solution (NaHCO3), dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to afford the target product, 2,2-dimethyl-3-(Boc-amino)-1-propanol, as a white solid (3.40 g, quantitative yield).The LC-MS analysis showed the molecular ion peak as 226.20 (M + Na+).

References

[1] Patent: WO2011/71725, 2011, A1. Location in patent: Page/Page column 53
[2] ChemMedChem, 2014, vol. 9, # 1, p. 197 - 206
[3] Patent: WO2006/57868, 2006, A1. Location in patent: Page/Page column 72
[4] Patent: WO2018/109648, 2018, A1. Location in patent: Page/Page column 52; 56
[5] Patent: US2005/54701, 2005, A1

Carbamic acid, (3-hydroxy-2,2-dimethylpropyl)-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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Carbamic acid, (3-hydroxy-2,2-dimethylpropyl)-, 1,1-dimethylethyl ester (9CI) Suppliers

China 32 Europe 1 India 1 United Kingdom 1 United States 5 Global 40

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184357-44-6, Carbamic acid, (3-hydroxy-2,2-dimethylpropyl)-, 1,1-dimethylethyl ester (9CI)Related Search:

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Carbamic acid, (3-hydroxy-2,2-dimethylpropyl)-, 1,1-dimethylethyl ester (9CI)

3-(Boc-aMino)-2,2-diMethyl-1-propanol

3-(Boc-amino)-2,2-dimethylpropanol

tert-Butyl (3-hydroxy-2,2-dimethylpropyl)

Tert-butyl 3-Hydroxy-2,2-dimethylpropylcarbamate

Carbamic acid, N-(3-hydroxy-2,2-dimethylpropyl)-, 1,1-dimethylethyl ester

tert-butyl N-(3-hydroxy-2,2-dimethylpropyl)carbamate - [B21981]

184357-44-6

N-BOC