Carbamic acid, [(3R)-2-oxo-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI)

Product Name: Carbamic acid, [(3R)-2-oxo-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI)
CAS No.: 221874-51-7
Chemical Name: Carbamic acid, [(3R)-2-oxo-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI)
Synonyms: (R)-3-(Boc-aMino)-2-piperidone;-tert-Butyl (2-oxopiperidin-3-yl);(R)-3-(Boc-aMino)-2-oxopiperidine;(3R)-2-Oxo-3-(Boc-amino)piperidine;TERT-BUTYL (R)-2-OXOPIPERIDIN-3-YLCABAMATE;(R)-tert-butyl 2-oxopiperidin-3-ylcarbamate;tert-Butyl (R)-2-oxopiperidin-3-ylcarbamate;tert-butyl N-[(3R)-2-oxo-3-piperidyl]carbamate;(R)-3-(tert-butoxycarbonylamino)-2-piperidinone;tert-butyl N-[(3R)-2-oxopiperidin-3-yl]carbamate
CBNumber: CB71052982
Molecular Formula: C10H18N2O3
Formula Weight: 214.26
MOL File: 221874-51-7.mol

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Carbamic acid, [(3R)-2-oxo-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI) Property

Boiling point:: 405.6±34.0 °C(Predicted)
Density: 1.11±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 11.05±0.20(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 7346AJ
Product name: tert-Butyl(R)-2-oxopiperidin-3-ylcarbamate
Packaging: 250mg
Price: $107
Updated: 2021/12/16

Activate Scientific

Product number: AS23320
Product name: (R)-tert-butyl 2-Oxopiperidin-3-ylcarbamate
Purity: 95+% ee
Packaging: 250mg
Price: $189
Updated: 2021/12/16

Activate Scientific

Product number: AS23320
Product name: (R)-tert-butyl 2-Oxopiperidin-3-ylcarbamate
Purity: 95+% ee
Packaging: 1g
Price: $389
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0031948
Product name: TERT-BUTYL-(R)-2-OXOPIPERIDIN-3-YLCARBAMATE
Purity: 95.00%
Packaging: 5MG
Price: $498.3
Updated: 2021/12/16

Matrix Scientific

Product number: 132431
Product name: (R)-tert-Butyl2-oxopiperidin-3-ylcarbamate
Purity: 97%
Packaging: 1g
Price: $665
Updated: 2021/12/16

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Carbamic acid, [(3R)-2-oxo-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI) Chemical Properties,Usage,Production

Synthesis

24424-99-5

88763-76-2

221874-51-7

General procedure for the synthesis of (R)-tert-butyl(2-oxopiperidin-3-yl)carbamic acid from di-tert-butyl dicarbonate and (R)-3-aminopiperidin-2-one: (R)-3-aminopiperidin-2-one (1.00 g, 8.76 mmol) was dissolved in dichloromethane (15 mL), triethylamine (1.28 mL, 9.2 mmol) and di-tert-butyl dicarbonate were added. butyl dicarbonate (2.01 g, 9.2 mmol). The reaction mixture was stirred at room temperature for 12 hours and then concentrated under vacuum. The crude product was diluted with ether (50 mL) and filtered through a diatomaceous earth pad. The filtrate was evaporated to dryness and purified by silica gel column chromatography (50 g of silica gel, 100% ethyl acetate) to give 1.65 g of colorless foamy (R)-tert-butyl(2-oxopiperidin-3-yl)carbamic acid in 88% yield.

References

[1] Patent: JP5667692, 2015, B2. Location in patent: Paragraph 0199-0201
[2] Tetrahedron Letters, 1999, vol. 40, # 5, p. 935 - 938
[3] Tetrahedron, 1999, vol. 55, # 18, p. 5793 - 5808

Carbamic acid, [(3R)-2-oxo-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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Carbamic acid, [(3R)-2-oxo-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI) Suppliers

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Capot Chemical Co., Ltd

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Jiaxing Novartis Chemical Co., Ltd.

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View Lastest Price from Carbamic acid, [(3R)-2-oxo-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI) manufacturers

Career Henan Chemical Co

Product: Carbamic acid, [(3R)-2-oxo-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI) 221874-51-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-08

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