2,4-Dimethoxypyridine
- Product Name
- 2,4-Dimethoxypyridine
- CAS No.
- 18677-43-5
- Chemical Name
- 2,4-Dimethoxypyridine
- Synonyms
- dihexyllead;2,4-Dimthoxypyridine;2,4-DIMETHOXYPYRIDINE;2,4-DimethoxypyridineI;Pyridine, 2,4-dimethoxy-;2,4-Dimethoxypyridine,>98%
- CBNumber
- CB7105836
- Molecular Formula
- C7H9NO2
- Formula Weight
- 139.15
- MOL File
- 18677-43-5.mol
2,4-Dimethoxypyridine Property
- Boiling point:
- 200-201 °C
- Density
- 1.064±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 4.71±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D460078
- Product name
- 2,4-DimethoxypyridineI
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FD53612
- Product name
- 2,4-Dimethoxypyridine
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 089424
- Product name
- 2,4-Dimethoxypyridine
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- OR901626
- Product name
- 2,4-Dimethoxypyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $102
- Updated
- 2021/12/16
- Product number
- FD53612
- Product name
- 2,4-Dimethoxypyridine
- Packaging
- 2g
- Price
- $120
- Updated
- 2021/12/16
2,4-Dimethoxypyridine Chemical Properties,Usage,Production
Uses
2,4-Dimethoxypyridine is mainly used as an organic synthesis intermediate for the synthesis of drug compounds such as PI3K inhibitors and has potential applications in anti-tumor therapy.
Synthesis
26452-80-2
124-41-4
18677-43-5
General procedure for the synthesis of 2,4-dimethoxypyridine from 2,4-dichloropyridine and sodium methanol: Freshly prepared sodium methanol (24 g, 0.44 mol) was added to an anhydrous N-methyl-2-pyrrolidinone (80 mL) solution of 2,4-dichloropyridine (15 g, 0.10 mol). The reaction mixture was stirred at 120 °C for 6 hours. After completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate (800 mL) and washed with water. The organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated to give 2,4-dimethoxypyridine (4) as a colorless oil which was pure enough to be used in the next step. Yield: 11.2 g (80%).1H NMR (400 MHz, DMSO-d6): δ 3.80 (s, 3H), 3.84 (s, 3H), 6.33 (d, J = 2.0 Hz, 1H), 6.60 (dd, J = 2.0 Hz, J = 5.6 Hz, 1H), 7.97 (d, J = 5.6 Hz, 1H); 13C NMR (100 MHz, DMSO-d6): δ 167.5, 165.4, 147.4, 106.1, 93.8, 55.3, 53.1; HRMS (ESI) m/z calcd for C7H10NO2 [M+H]+: 140.0706; found: 140.0707.
References
[1] Xiaolin Li. “A Convenient Synthesis of Gimeracil.” Journal of Chemical Research-s 384 1 (2018): 33–34.
[2] Lucas Robke . “Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors.” Tetrahedron 74 35 (2018): Pages 4531-4537.
2,4-Dimethoxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Dimethoxypyridine manufacturers
- Product
- 2,4-DIMETHOXYPYRIDINE 18677-43-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-13