Benzonitrile, 5-amino-2-methoxy- (9CI)
- Product Name
- Benzonitrile, 5-amino-2-methoxy- (9CI)
- CAS No.
- 214623-57-1
- Chemical Name
- Benzonitrile, 5-amino-2-methoxy- (9CI)
- Synonyms
- Albb-004948;3-Cyano-4-methoxyaniline;2-Methoxy-5-amnobenzonitrile;2-Methoxy-5-aMinobenzonitrile;5-amino-2-methoxybenzonitrile;Benzonitrile, 5-amino-2-methoxy-;5-Amino-2-methoxybenzonitrile 98%;Benzonitrile, 5-amino-2-methoxy- (9CI);5-amino-2-methoxybenzonitrile(SALTDATA: FREE)
- CBNumber
- CB71071406
- Molecular Formula
- C8H8N2O
- Formula Weight
- 148.16
- MOL File
- 214623-57-1.mol
Benzonitrile, 5-amino-2-methoxy- (9CI) Property
- Melting point:
- 100 °C
- Boiling point:
- 347.5±22.0 °C(Predicted)
- Density
- 1.17±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- Solid
- pka
- 3.39±0.10(Predicted)
- Appearance
- Brown to gray Solid
- InChI
- InChI=1S/C8H8N2O/c1-11-8-3-2-7(10)4-6(8)5-9/h2-4H,10H2,1H3
- InChIKey
- BZNMIDYUSWEPOM-UHFFFAOYSA-N
- SMILES
- C(#N)C1=CC(N)=CC=C1OC
Safety
- HazardClass
- IRRITANT
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A612473
- Product name
- 5-amino-2-methoxybenzonitrile
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 0917AB
- Product name
- 2-Methoxy-5-aminobenzonitrile
- Packaging
- 1g
- Price
- $181
- Updated
- 2021/12/16
- Product number
- 4637-1-17
- Product name
- 5-Amino-2-methoxybenzonitrile
- Packaging
- 1g
- Price
- $184
- Updated
- 2021/12/16
- Product number
- FA116318
- Product name
- 5-Amino-2-methoxybenzonitrile
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FA116318
- Product name
- 5-Amino-2-methoxybenzonitrile
- Packaging
- 100mg
- Price
- $58
- Updated
- 2021/12/16
Benzonitrile, 5-amino-2-methoxy- (9CI) Chemical Properties,Usage,Production
Synthesis
10496-75-0
214623-57-1
General procedure for the synthesis of 5-amino-2-methoxybenzonitrile from 2-methoxy-5-nitrobenzonitrile: 2-methoxy-5-nitrobenzonitrile (1 equiv., 220 mg, 1.23 mmol), methanol (20 mL), and carbon-carrying palladium (10% mass, 10 mg) were added sequentially to a 100 mL round-bottom flask. The flask was connected to a three-way system and the reaction was stirred at room temperature. Evacuation was carried out and then filled with nitrogen, and this cycle was repeated three times, each time the nitrogen was filled for not less than 5 minutes. The reaction was allowed to proceed at room temperature for 30 minutes under hydrogen protection. Upon completion of the reaction, the palladium-carbon catalyst was removed by filtration, the filtrate was concentrated and purified by column chromatography (petroleum ether:ethyl acetate = 5:1) to afford 150 mg of the target product 5-amino-2-methoxybenzonitrile (Compound 7) as a white crystalline solid in 82% yield.
References
[1] Patent: CN106892871, 2017, A. Location in patent: Paragraph 0109; 0112; 0113
[2] Patent: CN105294584, 2016, A. Location in patent: Paragraph 0018; 0019
[3] Journal of the Chemical Society, 1945, p. 861,864
[4] Chemical Biology and Drug Design, 2018, vol. 91, # 2, p. 526 - 533
Benzonitrile, 5-amino-2-methoxy- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
Benzonitrile, 5-amino-2-methoxy- (9CI) Suppliers
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View Lastest Price from Benzonitrile, 5-amino-2-methoxy- (9CI) manufacturers
- Product
- Benzonitrile, 5-amino-2-methoxy- (9CI) 214623-57-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-06
- Product
- Benzonitrile, 5-amino-2-methoxy- (9CI) 214623-57-1
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10000MT
- Release date
- 2023-08-08
- Product
- Benzonitrile, 5-amino-2-methoxy- (9CI) 214623-57-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-12-20