7-Deaza-2'-C-methyladenosine

Product Name: 7-Deaza-2'-C-methyladenosine
CAS No.: 443642-29-3
Chemical Name: 7-Deaza-2'-C-methyladenosine
Synonyms: MK-608;MK-0608;Lamevudine;7-deaza-2C-Me-A;2'--C-Meth yltubercidin;2'-b-C-methyl tubercidin;7-Deaza-2'-C-methyladenosine;7-Deaza-2'-C-Methyladenosine;7H-PYRROLO[2,3-D]PYRIMIDIN-4-A;2’-b-C-Methyl-7-deazaadenosine
CBNumber: CB71074003
Molecular Formula: C12H16N4O4
Formula Weight: 280.28
MOL File: 443642-29-3.mol

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7-Deaza-2'-C-methyladenosine Property

Melting point:: 222 °C(Solv: methanol (67-56-1); acetonitrile (75-05-8))
Boiling point:: 620.7±55.0 °C(Predicted)
Density: 1.75±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 12.51±0.70(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1/C12H16N4O4/c1-12(19)8(18)7(4-17)20-11(12)16-3-2-6-9(13)14-5-15-10(6)16/h2-3,5,7-8,11,17-19H,4H2,1H3,(H2,13,14,15)/t7-,8-,11-,12-/s3
InChIKey: IRZRJANZDIOOIF-ULJXVLPWNA-N
SMILES: C[C@]1([C@@H]([C@@H](CO)O[C@H]1N1C=CC2=C(N=CN=C12)N)O)O |&1:1,2,3,7,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3200
Product name: MK-0608
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $112
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3200
Product name: MK-0608
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $360
Updated: 2024/03/01

TRC

Product number: D201650
Product name: 7-Deaza-2''-C-methyladenosine
Packaging: 25mg
Price: $160
Updated: 2021/12/16

TRC

Product number: D201650
Product name: 7-Deaza-2''-C-methyladenosine
Packaging: 100mg
Price: $605
Updated: 2021/12/16

Biosynth Carbosynth

Product number: ND08351
Product name: 7-Deaza-2'-C-methyladenosine
Packaging: 10mg
Price: $85
Updated: 2021/12/16

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7-Deaza-2'-C-methyladenosine Chemical Properties,Usage,Production

Uses

7-Deaza-2''-C-methyladenosine is a hepatitis C virus (HCV) polymerase inhibitor.

Definition

MK 0608 (7-Deaza-2'-C-methyladenosine) is an anti-viral agent against Hepatitis C Virus (HCV). It has been shown to inhibit viral RNA replication in the subgenomic HCV genotype 1b replicon, with a 50% effective concentration (EC50) of 0.3 μM (EC90 = 1.3 μM). To determine efficacy in vivo, MK-0608 was administered to HCV-infected chimpanzees, resulting in dose- and time-dependent decreases in plasma viral loads. In separate experiments, chimpanzees dosed for 7 days with MK-0608 at 0.2 and 2 mg per kg of body weight per day by intravenous administration experienced average reductions in viral load of 1.0 and >5 log10 IU/ml, respectively.

Solubility in organics

Soluble in DMSO, not in water.

storage

Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

7-Deaza-2'-C-methyladenosine Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Deaza-2'-C-methyladenosine Suppliers

China 53 Germany 1 India 1 Switzerland 1 United Kingdom 3 United States 3 Global 62

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View Lastest Price from 7-Deaza-2'-C-methyladenosine manufacturers

Career Henan Chemical Co

Product: Lamevudine 443642-29-3
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-08-05

443642-29-3, 7-Deaza-2'-C-methyladenosineRelated Search:

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7-Deaza-2'-C-methyladenosine

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2’-beta-C-methyl tubercidin, 4-Amino-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo [2,3-d]pyrimidine, MRK608

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7-deaza-2C-Me-A

2’-b-C-Methyl tubercidin,2’-b-C-Methyl-7-deazaadenosine, MKR608, antiviral, HCV inhibitor

2’-b-C-Methyl-7-deazaadenosine

inhibit,MK-0608,Inhibitor,MK 0608,HCV,MK0608,Hepatitis C virus

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7-?(2-?C-?methyl-?β-?D-?ribofuranosyl)?-7H-?Pyrrolo[2,?3-?d]?pyrimidin-?4-?amine

7-Deaza-2'-C-Methyladenosine

443642-29-3