7-Deaza-2'-C-methyladenosine

Product Name: 7-Deaza-2'-C-methyladenosine
CAS No.: 443642-29-3
Chemical Name: 7-Deaza-2'-C-methyladenosine
Synonyms: MK-608;MK-0608;Lamevudine;7-deaza-2C-Me-A;MK-0608, 10 mM in DMSO;2'--C-Meth yltubercidin;2'-b-C-methyl tubercidin;7-Deaza-2'-C-methyladenosine;7H-PYRROLO[2,3-D]PYRIMIDIN-4-A;2’-b-C-Methyl-7-deazaadenosine
CBNumber: CB71074003
Molecular Formula: C12H16N4O4
Formula Weight: 280.28
MOL File: 443642-29-3.mol

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7-Deaza-2'-C-methyladenosine Property

Melting point:: 222 °C(Solv: methanol (67-56-1); acetonitrile (75-05-8))
Boiling point:: 620.7±55.0 °C(Predicted)
Density: 1.75±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: Slightly soluble: 0.1-1 mg/ml
form: Solid
pka: 12.51±0.70(Predicted)
color: White to off-white
InChI: InChI=1/C12H16N4O4/c1-12(19)8(18)7(4-17)20-11(12)16-3-2-6-9(13)14-5-15-10(6)16/h2-3,5,7-8,11,17-19H,4H2,1H3,(H2,13,14,15)/t7-,8-,11-,12-/s3
InChIKey: IRZRJANZDIOOIF-ULJXVLPWNA-N
SMILES: C[C@]1([C@@H]([C@@H](CO)O[C@H]1N1C=CC2=C(N=CN=C12)N)O)O |&1:1,2,3,7,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3200
Product name: MK-0608
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $109.25
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3200
Product name: MK-0608
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $370
Updated: 2025/07/31

TRC

Product number: D201650
Product name: 7-Deaza-2''-C-methyladenosine
Packaging: 25mg
Price: $160
Updated: 2021/12/16

TRC

Product number: D201650
Product name: 7-Deaza-2''-C-methyladenosine
Packaging: 100mg
Price: $605
Updated: 2021/12/16

Biosynth Carbosynth

Product number: ND08351
Product name: 7-Deaza-2'-C-methyladenosine
Packaging: 10mg
Price: $85
Updated: 2021/12/16

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7-Deaza-2'-C-methyladenosine Chemical Properties,Usage,Production

Uses

7-Deaza-2''-C-methyladenosine is a hepatitis C virus (HCV) polymerase inhibitor.

Definition

MK 0608 (7-Deaza-2'-C-methyladenosine) is an anti-viral agent against Hepatitis C Virus (HCV). It has been shown to inhibit viral RNA replication in the subgenomic HCV genotype 1b replicon, with a 50% effective concentration (EC50) of 0.3 μM (EC90 = 1.3 μM). To determine efficacy in vivo, MK-0608 was administered to HCV-infected chimpanzees, resulting in dose- and time-dependent decreases in plasma viral loads. In separate experiments, chimpanzees dosed for 7 days with MK-0608 at 0.2 and 2 mg per kg of body weight per day by intravenous administration experienced average reductions in viral load of 1.0 and >5 log10 IU/ml, respectively.

in vivo

Oral dosing of MK-0608 results in a potent antiviral effect. In preclinical pharmacokinetic experiments with rats, dogs, and rhesus monkeys, MK-0608 demonstrates good to excellent oral bioavailability (50 to 100%) and long plasma half-lives in dogs and rhesus macaques (9 and 14 h, respectively)^[1].

Animal Model:	The HCV-infected chimpanzees^[1]
Dosage:	1 mg/kg
Administration:	Administered orally; once daily for 37 days
Result:	Chimpanzee X6 had a baseline viral load that varied from 1,110 to 12,900 IU/mL, and chimpanzee X4 had a baseline viral load of 3×10⁶ to 9×10⁶ IU/mL.

Solubility in organics

Soluble in DMSO, not in water.

storage

Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

References

[1] DAVID B OLSEN. A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties.[J]. Antimicrobial Agents and Chemotherapy, 2004, 48 10: 3944-3953. DOI: 10.1128/aac.48.10.3944-3953.2004
[2] JOANNA ŻMURKO. The Viral Polymerase Inhibitor 7-Deaza-2’-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model[J]. PLoS Neglected Tropical Diseases, 2016, 10 1. DOI: 10.1101/041905

7-Deaza-2'-C-methyladenosine Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Deaza-2'-C-methyladenosine Suppliers

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View Lastest Price from 7-Deaza-2'-C-methyladenosine manufacturers

Career Henan Chemical Co

Product: Lamevudine 443642-29-3
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-08-05

443642-29-3, 7-Deaza-2'-C-methyladenosineRelated Search:

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2’-beta-C-methyl tubercidin, 4-Amino-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo [2,3-d]pyrimidine, MRK608

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7-deaza-2C-Me-A

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MK-0608, 10 mM in DMSO

443642-29-3