ChemicalBook > CAS DataBase List > 7-Deaza-2'-C-methyladenosine

7-Deaza-2'-C-methyladenosine

Product Name
7-Deaza-2'-C-methyladenosine
CAS No.
443642-29-3
Chemical Name
7-Deaza-2'-C-methyladenosine
Synonyms
MK-608;MK-0608;Lamevudine;7-deaza-2C-Me-A;2'--C-Meth yltubercidin;2'-b-C-methyl tubercidin;7-Deaza-2'-C-methyladenosine;7-Deaza-2'-C-Methyladenosine;7H-PYRROLO[2,3-D]PYRIMIDIN-4-A;2’-b-C-Methyl-7-deazaadenosine
CBNumber
CB71074003
Molecular Formula
C12H16N4O4
Formula Weight
280.28
MOL File
443642-29-3.mol
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7-Deaza-2'-C-methyladenosine Property

Melting point:
222 °C(Solv: methanol (67-56-1); acetonitrile (75-05-8))
Boiling point:
620.7±55.0 °C(Predicted)
Density 
1.75±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
12.51±0.70(Predicted)
InChI
InChI=1/C12H16N4O4/c1-12(19)8(18)7(4-17)20-11(12)16-3-2-6-9(13)14-5-15-10(6)16/h2-3,5,7-8,11,17-19H,4H2,1H3,(H2,13,14,15)/t7-,8-,11-,12-/s3
InChIKey
IRZRJANZDIOOIF-ULJXVLPWNA-N
SMILES
C[C@]1([C@@H]([C@@H](CO)O[C@H]1N1C=CC2=C(N=CN=C12)N)O)O |&1:1,2,3,7,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3200
Product name
MK-0608
Purity
≥98% (HPLC)
Packaging
5MG
Price
$112
Updated
2024/03/01
Sigma-Aldrich
Product number
SML3200
Product name
MK-0608
Purity
≥98% (HPLC)
Packaging
25MG
Price
$360
Updated
2024/03/01
TRC
Product number
D201650
Product name
7-Deaza-2''-C-methyladenosine
Packaging
25mg
Price
$160
Updated
2021/12/16
TRC
Product number
D201650
Product name
7-Deaza-2''-C-methyladenosine
Packaging
100mg
Price
$605
Updated
2021/12/16
Biosynth Carbosynth
Product number
ND08351
Product name
7-Deaza-2'-C-methyladenosine
Packaging
10mg
Price
$85
Updated
2021/12/16
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7-Deaza-2'-C-methyladenosine Chemical Properties,Usage,Production

Uses

7-Deaza-2''-C-methyladenosine is a hepatitis C virus (HCV) polymerase inhibitor.

Definition

MK 0608 (7-Deaza-2'-C-methyladenosine) is an anti-viral agent against Hepatitis C Virus (HCV). It has been shown to inhibit viral RNA replication in the subgenomic HCV genotype 1b replicon, with a 50% effective concentration (EC50) of 0.3 μM (EC90 = 1.3 μM). To determine efficacy in vivo, MK-0608 was administered to HCV-infected chimpanzees, resulting in dose- and time-dependent decreases in plasma viral loads. In separate experiments, chimpanzees dosed for 7 days with MK-0608 at 0.2 and 2 mg per kg of body weight per day by intravenous administration experienced average reductions in viral load of 1.0 and >5 log10 IU/ml, respectively.

Solubility in organics

Soluble in DMSO, not in water.

storage

Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

7-Deaza-2'-C-methyladenosine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 7-Deaza-2'-C-methyladenosine manufacturers

Career Henan Chemical Co
Product
Lamevudine 443642-29-3
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-08-05

443642-29-3, 7-Deaza-2'-C-methyladenosineRelated Search:


  • 7-(2-C-Methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • 2'-b-C-methyl tubercidin
  • Lamevudine
  • 7-Deaza-2'-C-methyladenosine
  • (2R,3R,4R,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol
  • (2R,3R,4R,5R)-2-(4-aMino-7H-pyrrolo[2,3-d]pyriMidin-7-yl)-5-(hyd
  • MK-0608
  • 7H-PYRROLO[2,3-D]PYRIMIDIN-4-A
  • 7-(2-C-Methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • (2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol
  • 4-Amino-7-(2--C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
  • 2'--C-Meth yltubercidin
  • 4-Amino-7-(2-beta-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
  • MK-608
  • 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(2-C-methyl-β-D-ribofuranosyl)-
  • 2’-beta-C-methyl tubercidin, 4-Amino-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo [2,3-d]pyrimidine, MRK608
  • (2R,3R,4R,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol
  • 7-deaza-2C-Me-A
  • 2’-b-C-Methyl tubercidin,2’-b-C-Methyl-7-deazaadenosine, MKR608, antiviral, HCV inhibitor
  • 2’-b-C-Methyl-7-deazaadenosine
  • inhibit,MK-0608,Inhibitor,MK 0608,HCV,MK0608,Hepatitis C virus
  • 7H-Pyrrolo[2,3-D]pyrimidin-4-amine,7-(2-c-methyl-b-d-ribofuranosyl)-
  • 7-?(2-?C-?methyl-?β-?D-?ribofuranosyl)?-7H-?Pyrrolo[2,?3-?d]?pyrimidin-?4-?amine
  • 7-Deaza-2'-C-Methyladenosine
  • 443642-29-3