ChemicalBook > CAS DataBase List > 7-Deaza-2'-C-methyladenosine

7-Deaza-2'-C-methyladenosine

Product Name
7-Deaza-2'-C-methyladenosine
CAS No.
443642-29-3
Chemical Name
7-Deaza-2'-C-methyladenosine
Synonyms
MK-608;MK-0608;Lamevudine;7-deaza-2C-Me-A;2'--C-Meth yltubercidin;2'-b-C-methyl tubercidin;7-Deaza-2'-C-methyladenosine;7-Deaza-2'-C-Methyladenosine;7H-PYRROLO[2,3-D]PYRIMIDIN-4-A;2’-b-C-Methyl-7-deazaadenosine
CBNumber
CB71074003
Molecular Formula
C12H16N4O4
Formula Weight
280.28
MOL File
443642-29-3.mol
More
Less

7-Deaza-2'-C-methyladenosine Property

Melting point:
222 °C(Solv: methanol (67-56-1); acetonitrile (75-05-8))
Boiling point:
620.7±55.0 °C(Predicted)
Density 
1.75±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
12.51±0.70(Predicted)
form 
Solid
color 
White to off-white
InChI
InChI=1/C12H16N4O4/c1-12(19)8(18)7(4-17)20-11(12)16-3-2-6-9(13)14-5-15-10(6)16/h2-3,5,7-8,11,17-19H,4H2,1H3,(H2,13,14,15)/t7-,8-,11-,12-/s3
InChIKey
IRZRJANZDIOOIF-ULJXVLPWNA-N
SMILES
C[C@]1([C@@H]([C@@H](CO)O[C@H]1N1C=CC2=C(N=CN=C12)N)O)O |&1:1,2,3,7,r|
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3200
Product name
MK-0608
Purity
≥98% (HPLC)
Packaging
5MG
Price
$112
Updated
2024/03/01
Sigma-Aldrich
Product number
SML3200
Product name
MK-0608
Purity
≥98% (HPLC)
Packaging
25MG
Price
$360
Updated
2024/03/01
TRC
Product number
D201650
Product name
7-Deaza-2''-C-methyladenosine
Packaging
25mg
Price
$160
Updated
2021/12/16
TRC
Product number
D201650
Product name
7-Deaza-2''-C-methyladenosine
Packaging
100mg
Price
$605
Updated
2021/12/16
Biosynth Carbosynth
Product number
ND08351
Product name
7-Deaza-2'-C-methyladenosine
Packaging
10mg
Price
$85
Updated
2021/12/16
More
Less

7-Deaza-2'-C-methyladenosine Chemical Properties,Usage,Production

Uses

7-Deaza-2''-C-methyladenosine is a hepatitis C virus (HCV) polymerase inhibitor.

Definition

MK 0608 (7-Deaza-2'-C-methyladenosine) is an anti-viral agent against Hepatitis C Virus (HCV). It has been shown to inhibit viral RNA replication in the subgenomic HCV genotype 1b replicon, with a 50% effective concentration (EC50) of 0.3 μM (EC90 = 1.3 μM). To determine efficacy in vivo, MK-0608 was administered to HCV-infected chimpanzees, resulting in dose- and time-dependent decreases in plasma viral loads. In separate experiments, chimpanzees dosed for 7 days with MK-0608 at 0.2 and 2 mg per kg of body weight per day by intravenous administration experienced average reductions in viral load of 1.0 and >5 log10 IU/ml, respectively.

Solubility in organics

Soluble in DMSO, not in water.

storage

Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

7-Deaza-2'-C-methyladenosine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

7-Deaza-2'-C-methyladenosine Suppliers

NewCan Biotech Limited
Tel
+86-0571-86912261 +86-15658003402
Email
sales@newcanbio.com
Country
China
ProdList
355
Advantage
58
Hangzhou FuRun Pharmaceutical Technology Co., Ltd
Tel
15658004993
Email
1900830611@qq.com
Country
China
ProdList
965
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
Advantage
58
Nanjing Baifuli Technology Co., Ltd.
Tel
25-25-58740604 15951658055
Fax
+86-25-58356858
Email
sales@unisyn.cn
Country
China
ProdList
561
Advantage
58
Zhengzhou GranLen pharmaceutical Technology Co., Ltd.
Tel
0371-85513397
Email
info@granlen.com
Country
China
ProdList
497
Advantage
55
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
NINGBO INNO PHARMCHEM CO.,LTD.
Tel
86-574-27787657
Fax
86-574-27912196
Email
info@dearchem.com
Country
China
ProdList
4613
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
Country
China
ProdList
16684
Advantage
50
Wuhu Nuowei Chemical Technology Co., Ltd
Tel
0553-8233716 18055326116
Email
sales@nuowei-chem.com
Country
China
ProdList
951
Advantage
55
More
Less

View Lastest Price from 7-Deaza-2'-C-methyladenosine manufacturers

Career Henan Chemical Co
Product
Lamevudine 443642-29-3
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-08-05

443642-29-3, 7-Deaza-2'-C-methyladenosineRelated Search:


  • 7-(2-C-Methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • 2'-b-C-methyl tubercidin
  • Lamevudine
  • 7-Deaza-2'-C-methyladenosine
  • (2R,3R,4R,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol
  • (2R,3R,4R,5R)-2-(4-aMino-7H-pyrrolo[2,3-d]pyriMidin-7-yl)-5-(hyd
  • MK-0608
  • 7H-PYRROLO[2,3-D]PYRIMIDIN-4-A
  • 7-(2-C-Methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • (2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol
  • 4-Amino-7-(2--C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
  • 2'--C-Meth yltubercidin
  • 4-Amino-7-(2-beta-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
  • MK-608
  • 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(2-C-methyl-β-D-ribofuranosyl)-
  • 2’-beta-C-methyl tubercidin, 4-Amino-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo [2,3-d]pyrimidine, MRK608
  • (2R,3R,4R,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol
  • 7-deaza-2C-Me-A
  • 2’-b-C-Methyl tubercidin,2’-b-C-Methyl-7-deazaadenosine, MKR608, antiviral, HCV inhibitor
  • 2’-b-C-Methyl-7-deazaadenosine
  • inhibit,MK-0608,Inhibitor,MK 0608,HCV,MK0608,Hepatitis C virus
  • 7H-Pyrrolo[2,3-D]pyrimidin-4-amine,7-(2-c-methyl-b-d-ribofuranosyl)-
  • 7-?(2-?C-?methyl-?β-?D-?ribofuranosyl)?-7H-?Pyrrolo[2,?3-?d]?pyrimidin-?4-?amine
  • 7-Deaza-2'-C-Methyladenosine
  • 443642-29-3