ChemicalBook > CAS DataBase List > 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
- Product Name
- 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
- CAS No.
- 98141-42-5
- Chemical Name
- 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
- Synonyms
- 4,6-Dichloro-1-Methyl-1H-...;4,6-Dichloro-1-methyl-pyrazolo3,4-dpyrimidine;4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine;1H-Pyrazolo[3,4-d]pyriMidine, 4,6-dichloro-1-Methyl-
- CBNumber
- CB71076698
- Molecular Formula
- C6H4Cl2N4
- Formula Weight
- 203.03
- MOL File
- 98141-42-5.mol
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4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine Property
- Boiling point:
- 284℃
- Density
- 1.76
- Flash point:
- 125℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.19±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
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N-Bromosuccinimide Price
TRC
- Product number
- D482655
- Product name
- 4,6-Dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
- Packaging
- 100mg
- Price
- $110
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR30658
- Product name
- 4,6-Dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
- Packaging
- 250mg
- Price
- $72
- Updated
- 2021/12/16
Frontier Specialty Chemicals
- Product number
- D11611
- Product name
- 4,6-Dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
- Purity
- 95%
- Packaging
- 500mg
- Price
- $80
- Updated
- 2021/12/16
Frontier Specialty Chemicals
- Product number
- D11611
- Product name
- 4,6-Dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
- Purity
- 95%
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H32-5-H7
- Product name
- 4,6-Dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
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4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine Chemical Properties,Usage,Production
Synthesis
4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine is prepared by the reaction of Methylhydrazine and 2,4,6-trichloropyrimidine-5-carbaldehyde. The specific synthesis steps are as follows:
To a solution of 2,4,6-trichloropyrimidine-5-carbaldehyde (8 g, 37.84 mmol, 1.00 equiv) in ethanol (120 mL) was added a 40percent water solution of methylhydrazine (4 mL, 37.98 mmol, 1.00 equiv) and triethylamine (16 mL) at -78° C.
The resulting mixture was stirred for 30 min at -78° C. and then 2 h at 0° C.
After completion the reaction was concentrated under vacuum without heating.
Then ethyl acetate was added and the solution was washed with saturated ammonium chloride solution.
The organic layer was dried over anhydrous sodium sulfate and concentrated under vacuum without heating.
The residue was purified by silica gel column chromatography eluting with ethyl acetate/petroleum ether (1:1) to afford 6 g (78percent) of 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine as a white solid. LC-MS (ES, m/z): 203 [M+H]+.
4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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98141-42-5, 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidineRelated Search:
4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
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