ABAPERIDONE
- Product Name
- ABAPERIDONE
- CAS No.
- 183849-43-6
- Chemical Name
- ABAPERIDONE
- Synonyms
- ABAPERIDONE;4H-1-Benzopyran-4-one, 7-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-(hydroxymethyl)-
- CBNumber
- CB71092474
- Molecular Formula
- C25H25FN2O5
- Formula Weight
- 452.47
- MOL File
- 183849-43-6.mol
ABAPERIDONE Property
- Boiling point:
- 667.3±55.0 °C(Predicted)
- Density
- 1.320±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 13.48±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- HCH0136037
- Product name
- 7-(3-[4-(6-FLUORO-1,2-BENZOXAZOL-3-YL)PIPERIDIN-1-YL]PROPOXY)-3-(HYDROXYMETHYL)-4H-CHROMEN-4-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.47
- Updated
- 2021/12/16
ABAPERIDONE Chemical Properties,Usage,Production
Uses
Abaperidone is a potent antagonist of 5-HT2A receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM.
in vivo
The time course of the inhibition of climbing behavior for a period of several hours after oral administration of either 0.5 mg/kg of Abaperidone or risperidone is tested in mice. Also is included a comparative test of catalepsy induced by Abaperidone and risperidone along several hours following oral administration at several doses in rats. A somewhat lesser induction of catalepsy is observed for Abaperidone. A study of serum prolactin levels after oral administration of Abaperidone, haloperidol, and risperidone at 5 mg/kg for either 1 or 3 days in rats. Increases in prolactin levels after oral administration of Abaperidone are smaller than those for reference drugs[1].
IC 50
D2 Receptor: 17 nM (IC50); 5-HT2A Receptor: 6.2 nM (IC50)
References
[1] Bolós J, et al. 7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602). J Med Chem. 1998 Dec 31;41(27):5402-9. DOI:10.1021/jm9810396
ABAPERIDONE Preparation Products And Raw materials
Raw materials
Preparation Products
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