6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

Product Name: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride
CAS No.: 84163-13-3
Chemical Name: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride
Synonyms: 6-FLUORO-3-(PIPERIDIN-4-YL)BENZO[D]ISOXAZOLE;6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride;Paliperidone int 2;TIMTEC-BB SBB011438;2-benzisoxazole HCl;6-Fluoro-3-(4-piperi;Paliperidone USP RC B;6--3-(4-)-1,2 KY-16-05;Risperidone Impurity M;ASINEX-REAG BAS 13549338
CBNumber: CB1173972
Molecular Formula: C12H14ClFN2O
Formula Weight: 256.7
MOL File: 84163-13-3.mol

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6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Property

Melting point:: 293-295 °C
Density: 1.42g/cm3 at 20℃
vapor pressure: 0.002-0.005Pa at 20-25℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly, Heated), Methanol (Very Slightly, Heated), Water (Slightly, Heated)
form: Solid
color: White to Off-White
InChI: InChI=1S/C12H13FN2O.ClH/c13-9-1-2-10-11(7-9)16-15-12(10)8-3-5-14-6-4-8;/h1-2,7-8,14H,3-6H2;1H
InChIKey: CWPSRUREOSBKBQ-UHFFFAOYSA-N
SMILES: N1OC2C=C(C=CC=2C=1C1CCNCC1)F.Cl
LogP: -0.84 at 20℃ and pH7
CAS DataBase Reference: 84163-13-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2934990002

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: F0944
Product name: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: F0944
Product name: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $61
Updated: 2025/07/31

TRC

Product number: F595580
Product name: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride
Packaging: 5g
Price: $120
Updated: 2021/12/16

TRC

Product number: F595580
Product name: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride
Packaging: 25g
Price: $340
Updated: 2021/12/16

Apolloscientific

Product number: PC6042
Product name: 6-Fluoro-3-(piperidin-4-yl)-1,2-benzisoxazolehydrochloride
Packaging: 1g
Price: $10
Updated: 2021/12/16

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6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Chemical Properties,Usage,Production

Uses

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride (Risperidone EP Impurity M; Paliperidone USP Related Compound B) is a novel antiproliferative agent.

Synthesis

135634-18-3

84163-13-3

The general procedure for the synthesis of 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride from (2,4-difluorophenyl)-(4-piperidinyl)methanone oxime hydrochloride was as follows: potassium hydroxide (27 g) was dissolved in 600 mL of methanol, followed by addition of (2,4-difluorophenyl)-(4-piperidinyl)methanone oxime hydrochloride (55 g). The reaction mixture was heated to reflux for about 2.5 hours. After completion of the reaction, it was cooled to room temperature, dried by adding an appropriate amount of anhydrous magnesium sulfate and stirred for about 1 hour. The filtrate was concentrated under reduced pressure to remove the solvent. To the concentrate was added 500mL of acetone, stirred at room temperature for about 0.5 hours, and filtered to remove insoluble material. Hydrochloric acid was slowly added to the filtrate and the pH was adjusted to 2?3, precipitating a white solid. The solid was collected by filtration and dried to give 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride (35 g) with 0.4% methanol.

References

[1] Patent: CN106831742, 2017, A. Location in patent: Paragraph 0041; 0042

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Suppliers

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View Lastest Price from 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride manufacturers

Hebei Junhua Import and Export Co., LTD

Product: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride 84163-13-3
Price: US $120.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000
Release date: 2025-03-21

Henan Bao Enluo International TradeCo.，LTD

Product: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride 84163-13-3
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500t/month
Release date: 2023-08-17

Shanghai CRM New Material Technology Co., LTD

Product: 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride 84163-13-3
Price: US $10.00-15.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 10t
Release date: 2022-09-21

84163-13-3, 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochlorideRelated Search:

DROPERIDOL Benperidol Topotecan hydrochloride Haloperidol ILOPERIDONE Paliperidone Ocaperidone Risperidone Diphenoxylate 1,2-BENZISOXAZOLE Isoxazole 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole 5-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZISOXAZOLE HYDROCHLORIDE ABAPERIDONE 7-HYDROXY RISPERIDONE METHYL RISPERIDONE 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-7-methoxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)PIPERIDINE

ASINEX-REAG BAS 13549338

6--3-(4-)-1,2 KY-16-05

Paliperidone Related CoMpound B

1,2-Benzisoxazole,6-fluoro-3-(4-piperidinyl)-, hydrochloride (1:1)

Paliperidone int 2

Paliperidone Related Compound B (20 mg) (6-fluoro-3-(piperidin-4-yl)benzoisoxazole hydrochloride)

Iloperidone intermediate

Risperidone EP Impurity M

TIMTEC-BB SBB011438

1,2-BENZISOXAZOLE, 6-FLUORO-3-(4-PIPERIDINYL)-

6-FLUORO-3-(PIPERIDIN-4-YL)BENZO[D]ISOXAZOLE

6-FLUORO-3-(TETRAHYDROPYRIDINE-4-YL)BENZO[B]ISOXAZOLE

6-FLUORO-3-(4-PIPERIDYL)-1,2-BENZISOXAZOLE

Paliperidone Impurity 8(Paliperidone USP RC B)

Risperidone Impurity 13(Risperidone EP Impurity M)

Paliperidone Impurity O HCl (Iloperidone Impurity 16 HCl)

Paliperidone USP Related Compound B

Paliperidone Impurity O HCl (Iloperidone Impurity 16)

(5-chloro-2,4-difluorophenyl)(piperidin-4-yl)methanone

Paliperidone USP Related Compound B HCl (Risperidone EP Impurity M HCl)

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Paliperidone intermediate

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride (intermediate of risperidone)

6-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZISOXAZOLE HYDROCHLORIDE (RISPERIDONE INTERMEDIATE )

6-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZO[D]ISOXAZOLE HYDROCHLORIDE

6-Fluoro-3-(4-piperidinyl)benzisoxazole hydrochloride (Paliperidone)

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

6-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZISOXAZOLE HCL 98+%

6-Fluoro-3-piperidin-4-yl-1,2-benzisoxazole hydrochloride

6-Fluoro-3-(4-piperidyl)-1,2-benzisoxazole hydrochloride

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride ,99.5%

6-Fluoro-3-(4-piperi

6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

2-benzisoxazole HCl

6-Fluoro-3-piperid-4-yl-1

Paliperidone Intermediate 2

Paliperidone AMine IMpurity (USP RelatedCoMpound B)

Paliperidone USP RC B

4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride, 6-Fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

Paliperidone iMpurity O HCl

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride &gt

6-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZISOXAZOLE HYDROCHLORIDE84163-13-3

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride ISO 9001：2015 REACH

Risperidone Impurity M

Paliperidone Related Compund B (Paliperidone Amine Impurity/ Risperidone EP Impurity M)

Risperidone EP Impurity M (Paliperidone Related Compund B/ Paliperidone Amine Impurity)

4-(6-Fluoro-1,2-benzisoxazole-3yl)-Piperidine Hydrochloride

6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole HydrochlorideQ: What is 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride Q: What is the CAS Number of 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride Q: What is the storage condition of 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride Q: What are the applications of 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride

TIANFU-CHEM - 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

Paliperidone Related Compound B (6-fluoro-3-(piperidin-4-yl)benzoisoxazole hydrochloride) (1491820)

Paliperidone Related Compound B as Hydrochloride

Paliperidone USP Related Compound B as Hydrochloride

Paliperidone USP Related Compound B HCl

Risperidone Impurity M as Hydrochloride

Risperidone EP Impurity M as Hydrochloride

Risperidone EP Impurity M HCl

4-(6-Fluoro-1,2-Benzisoxazole-3Yl)-Piperidine Hcl

6-Fluro-3-(4-piperidinyl)-1,2- benzisoxazole hydrochloride