ChemicalBook > CAS DataBase List > 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

Product Name
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride
CAS No.
84163-13-3
Chemical Name
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride
Synonyms
6-FLUORO-3-(PIPERIDIN-4-YL)BENZO[D]ISOXAZOLE;6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride;Paliperidone int 2;TIMTEC-BB SBB011438;2-benzisoxazole HCl;6-Fluoro-3-(4-piperi;Paliperidone USP RC B;6--3-(4-)-1,2 KY-16-05;Risperidone Impurity M;ASINEX-REAG BAS 13549338
CBNumber
CB1173972
Molecular Formula
C12H14ClFN2O
Formula Weight
256.7
MOL File
84163-13-3.mol
More
Less

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Property

Melting point:
293-295 °C
Density 
1.42g/cm3 at 20℃
vapor pressure 
0.002-0.005Pa at 20-25℃
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly, Heated), Methanol (Very Slightly, Heated), Water (Slightly, Heated)
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C12H13FN2O.ClH/c13-9-1-2-10-11(7-9)16-15-12(10)8-3-5-14-6-4-8;/h1-2,7-8,14H,3-6H2;1H
InChIKey
CWPSRUREOSBKBQ-UHFFFAOYSA-N
SMILES
N1OC2C=C(C=CC=2C=1C1CCNCC1)F.Cl
LogP
-0.84 at 20℃ and pH7
CAS DataBase Reference
84163-13-3(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2934990002
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
F0944
Product name
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$31
Updated
2025/07/31
TCI Chemical
Product number
F0944
Product name
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$61
Updated
2025/07/31
TRC
Product number
F595580
Product name
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride
Packaging
5g
Price
$120
Updated
2021/12/16
TRC
Product number
F595580
Product name
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride
Packaging
25g
Price
$340
Updated
2021/12/16
AK Scientific
Product number
I388
Product name
6-Fluoro-3-piperid-4-yl-1,2-benzisoxazoleHCl
Packaging
100g
Price
$120
Updated
2021/12/16
More
Less

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Chemical Properties,Usage,Production

Uses

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride (Risperidone EP Impurity M; Paliperidone USP Related Compound B) is a novel antiproliferative agent.

Synthesis

135634-18-3

84163-13-3

The general procedure for the synthesis of 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride from (2,4-difluorophenyl)-(4-piperidinyl)methanone oxime hydrochloride was as follows: potassium hydroxide (27 g) was dissolved in 600 mL of methanol, followed by addition of (2,4-difluorophenyl)-(4-piperidinyl)methanone oxime hydrochloride (55 g). The reaction mixture was heated to reflux for about 2.5 hours. After completion of the reaction, it was cooled to room temperature, dried by adding an appropriate amount of anhydrous magnesium sulfate and stirred for about 1 hour. The filtrate was concentrated under reduced pressure to remove the solvent. To the concentrate was added 500mL of acetone, stirred at room temperature for about 0.5 hours, and filtered to remove insoluble material. Hydrochloric acid was slowly added to the filtrate and the pH was adjusted to 2?3, precipitating a white solid. The solid was collected by filtration and dried to give 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride (35 g) with 0.4% methanol.

References

[1] Patent: CN106831742, 2017, A. Location in patent: Paragraph 0041; 0042

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Suppliers

Americas 1 Canada 2 China 266 Europe 3 Germany 3 India 77 Japan 3 Russia 1 Slovakia 1 South Korea 1 Ukraine 1 United Kingdom 9 United States 42 Global 410
Jiangxi Zhiyan Biopharmaceutical Technology Co., Ltd
Tel
13970866816
Email
info@rochipharma.com
Country
China
ProdList
305
Advantage
58
Beijing Whale Technology Corporation Ltd.
Tel
010-83694934 13671295325
Email
sales@whalecorporation.com
Country
China
ProdList
109
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Hangzhou Minsuo Technology Co., Ltd.
Tel
571-88199336 18957129209
Fax
0571-88190523
Email
309645123@qq.com
Country
China
ProdList
53
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16077
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527621225
Email
1791901229@qq.com
Country
China
ProdList
6945
Advantage
52
Jinan Trio PharmaTech Co., Ltd.
Tel
0531-88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com
Country
China
ProdList
1856
Advantage
62
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
TIPR Pharmaceutical Responsible Co., Ltd.
Tel
022-23009155 23006946
Fax
022-27454635
Email
api@cnpha.com
Country
China
ProdList
28
Advantage
68
Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Fax
021-5649-1756
Email
2819742715@qq.com
Country
China
ProdList
4000
Advantage
55
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5645
Advantage
65
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5158
Advantage
50
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Moltt Biocem Co., Ltd.
Tel
+86-21-38682181 15900741819
Fax
+86-21-38682181
Country
China
ProdList
282
Advantage
55
China Nobel Chem Co., Limited
Tel
+86(0)21 60484900
Fax
+86(0)21 60484900
Country
China
ProdList
764
Advantage
50
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2864
Advantage
52
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3120
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4942
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
Shanghai QianJin Chemical Technology Co., Ltd
Tel
021-20900665 17321230821
Fax
021-20900665
Email
2986274987@qq.com
Country
China
ProdList
815
Advantage
55
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
Advantage
55
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9858
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
Nanjing XiZe Biotechnology CO., Ltd.
Tel
025-58362220 0086-15250997978
Fax
025-58362220
Email
sale@njxizebio.com
Country
China
ProdList
4855
Advantage
55
Struchem Co., Ltd.
Tel
0512-63009836 18994340901
Fax
0512-63006936
Email
helen@struchem.com
Country
China
ProdList
3981
Advantage
60
Shanghai Boyners Pharm-Tech Co., Ltd.
Tel
13817873692
Fax
021-31329586
Email
mkt@boynerspharm.com
Country
China
ProdList
1707
Advantage
55
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
JW & Y Pharmlab Co., Ltd.
Tel
021-64340559 13651849907;
Fax
021- 64345308
Email
xinyu_shi@jwypharmlab.com.cn
Country
China
ProdList
12000
Advantage
58
More
Less

View Lastest Price from 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride manufacturers

Henan Bao Enluo International TradeCo.，LTD
Product
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride 84163-13-3
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500t/month
Release date
2023-08-17
Shanghai CRM New Material Technology Co., LTD
Product
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride 84163-13-3
Price
US $10.00-15.00/g
Min. Order
10g
Purity
99%
Supply Ability
10t
Release date
2022-09-21
Jiangsu Monade Biological Technology Co., Ltd.
Product
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride 84163-13-3
Price
US $15.00/KG
Min. Order
1000KG
Purity
99.99%
Supply Ability
100000
Release date
2021-08-31

84163-13-3, 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochlorideRelated Search:

DROPERIDOL Benperidol Topotecan hydrochloride Haloperidol ILOPERIDONE Paliperidone Ocaperidone Risperidone Diphenoxylate 1,2-BENZISOXAZOLE Isoxazole 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole 5-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZISOXAZOLE HYDROCHLORIDE ABAPERIDONE 7-HYDROXY RISPERIDONE METHYL RISPERIDONE 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-7-methoxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

  • 4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)PIPERIDINE
  • ASINEX-REAG BAS 13549338
  • 6--3-(4-)-1,2 KY-16-05
  • Paliperidone Related CoMpound B
  • 1,2-Benzisoxazole,6-fluoro-3-(4-piperidinyl)-, hydrochloride (1:1)
  • Paliperidone int 2
  • Paliperidone Related Compound B (20 mg) (6-fluoro-3-(piperidin-4-yl)benzoisoxazole hydrochloride)
  • Iloperidone intermediate
  • Risperidone EP Impurity M
  • TIMTEC-BB SBB011438
  • 1,2-BENZISOXAZOLE, 6-FLUORO-3-(4-PIPERIDINYL)-
  • 6-FLUORO-3-(PIPERIDIN-4-YL)BENZO[D]ISOXAZOLE
  • 6-FLUORO-3-(TETRAHYDROPYRIDINE-4-YL)BENZO[B]ISOXAZOLE
  • 6-FLUORO-3-(4-PIPERIDYL)-1,2-BENZISOXAZOLE
  • Paliperidone Impurity 8(Paliperidone USP RC B)
  • Risperidone Impurity 13(Risperidone EP Impurity M)
  • Paliperidone Impurity O HCl (Iloperidone Impurity 16 HCl)
  • Paliperidone USP Related Compound B
  • Paliperidone Impurity O HCl (Iloperidone Impurity 16)
  • (5-chloro-2,4-difluorophenyl)(piperidin-4-yl)methanone
  • Paliperidone USP Related Compound B HCl (Risperidone EP Impurity M HCl)
  • 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Paliperidone intermediate
  • 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride (intermediate of risperidone)
  • 6-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZISOXAZOLE HYDROCHLORIDE (RISPERIDONE INTERMEDIATE )
  • 6-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZO[D]ISOXAZOLE HYDROCHLORIDE
  • 6-Fluoro-3-(4-piperidinyl)benzisoxazole hydrochloride (Paliperidone)
  • 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride
  • 6-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZISOXAZOLE HCL 98+%
  • 6-Fluoro-3-piperidin-4-yl-1,2-benzisoxazole hydrochloride
  • 6-Fluoro-3-(4-piperidyl)-1,2-benzisoxazole hydrochloride
  • 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride ,99.5%
  • 6-Fluoro-3-(4-piperi
  • 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
  • 2-benzisoxazole HCl
  • 6-Fluoro-3-piperid-4-yl-1
  • Paliperidone Intermediate 2
  • Paliperidone AMine IMpurity (USP RelatedCoMpound B)
  • Paliperidone USP RC B
  • 4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride, 6-Fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride
  • Paliperidone iMpurity O HCl
  • 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride &gt
  • 6-FLUORO-3-(4-PIPERIDINYL)-1,2-BENZISOXAZOLE HYDROCHLORIDE84163-13-3
  • 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride ISO 9001：2015 REACH
  • Risperidone Impurity M
  • Paliperidone Related Compund B (Paliperidone Amine Impurity/ Risperidone EP Impurity M)
  • Risperidone EP Impurity M (Paliperidone Related Compund B/ Paliperidone Amine Impurity)
  • 4-(6-Fluoro-1,2-benzisoxazole-3yl)-Piperidine Hydrochloride
  • 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole HydrochlorideQ: What is 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride Q: What is the CAS Number of 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride Q: What is the storage condition of 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride Q: What are the applications of 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride
  • TIANFU-CHEM - 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride
  • Paliperidone Related Compound B (6-fluoro-3-(piperidin-4-yl)benzoisoxazole hydrochloride) (1491820)
  • Paliperidone Related Compound B as Hydrochloride
  • Paliperidone USP Related Compound B as Hydrochloride
  • Paliperidone USP Related Compound B HCl
  • Risperidone Impurity M as Hydrochloride
  • Risperidone EP Impurity M as Hydrochloride
  • Risperidone EP Impurity M HCl
  • 4-(6-Fluoro-1,2-Benzisoxazole-3Yl)-Piperidine Hcl
  • 6-Fluro-3-(4-piperidinyl)-1,2- benzisoxazole hydrochloride