5-BROMOTHIAZOLE-2-CARBOXYLIC ACID
Uses- Product Name
- 5-BROMOTHIAZOLE-2-CARBOXYLIC ACID
- CAS No.
- 957346-62-2
- Chemical Name
- 5-BROMOTHIAZOLE-2-CARBOXYLIC ACID
- Synonyms
- 5-bromo-1,3-thiazole-2-carboxylic acid;5-BROMOTHIAZOLE-2-CARBOXYLIC ACID;5-bromo-2-Thiazole carbocylic acid;2-Thiazolecarboxylic acid, 5-bromo-
- CBNumber
- CB71092782
- Molecular Formula
- C4H2BrNO2S
- Formula Weight
- 208.03
- MOL File
- 957346-62-2.mol
5-BROMOTHIAZOLE-2-CARBOXYLIC ACID Property
- Boiling point:
- 372.5±34.0 °C(Predicted)
- Density
- 2.062±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 2.69±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P311Call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B704148
- Product name
- 5-Bromothiazole-2-carboxylicAcid
- Packaging
- 100mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 122200
- Product name
- 5-Bromothiazole-2-carboxylicacid
- Purity
- 90+%
- Packaging
- 1g
- Price
- $826
- Updated
- 2021/12/16
- Product number
- Y4853
- Product name
- 5-Bromothiazole-2-carboxylicacid
- Packaging
- 5g
- Price
- $2571
- Updated
- 2021/12/16
- Product number
- CM104806
- Product name
- 5-bromo-1,3-thiazole-2-carboxylicacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $1155
- Updated
- 2021/12/16
- Product number
- 957346622
- Product name
- 5-Bromothiazole-2-carboxylicacid
- Packaging
- 250mg
- Price
- $205.8
- Updated
- 2021/12/16
5-BROMOTHIAZOLE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
5-Bromo-1,3-thiazol-2-carboxylic acid is a thiazolium derivative used in pharmaceuticals and organic synthesis.
Synthesis
14190-59-1
957346-62-2
The general procedure for the synthesis of 5-bromothiazole-2-carboxylic acid from thiazole-2-carboxylic acid was as follows: thiazole-2-carboxylic acid (1.60 g, 12.4 mmol) was slowly added to dry tetrahydrofuran (THF, 100 mL) in a lithium diisopropylammonium (LDA, 1 M solution of THF/heptane/ethylbenzene, 26.0 mmol, 26 mL) solution. The reaction mixture was stirred at this temperature for 30 min. Subsequently, carbon tetrabromide (CBr4, 4.52 g, 13.6 mmol) was added and the reaction continued to be stirred for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (30 mL). After the mixture was brought to room temperature, it was diluted with saturated sodium bicarbonate (NaHCO3) aqueous solution (50 mL). The mixture was filtered through a diatomaceous earth pad and extracted with ethyl acetate (EtOAc, 50 mL). The organic layer was discarded and the aqueous layer was acidified with 1 M hydrochloric acid (HCl) to an acidic pH. The acidified aqueous solution was extracted with ethyl acetate (3 x 30 mL). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4), and concentrated in vacuum to give 5-bromothiazole-2-carboxylic acid (0.42 g, 2.0 mmol, 16% yield).LCMS analysis: [M + H]+ = 207.90, measured value 208.0.
References
[1] Patent: WO2015/161928, 2015, A1. Location in patent: Page/Page column 36; 53; 54
[2] Patent: WO2015/161924, 2015, A1. Location in patent: Page/Page column 30
5-BROMOTHIAZOLE-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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