METHYL 6-AMINO-5-BROMOPICOLINATE

Product Name: METHYL 6-AMINO-5-BROMOPICOLINATE
CAS No.: 178876-82-9
Chemical Name: METHYL 6-AMINO-5-BROMOPICOLINATE
Synonyms: methyl 6-amino-5-bromopicolinate;METHYL 6-AMINO-5-BROMOPYRIDINE-2-CARBOXYLATE;METHYL 6-AMINO-5-BROMOPICOLINATE ISO 9001：2015 REACH;6-AMino-5-broMopyridine-2-carboxylic Acid Methyl Ester;2-Pyridinecarboxylic acid, 6-amino-5-bromo-, methyl ester
CBNumber: CB8348980
Molecular Formula: C7H7BrN2O2
Formula Weight: 231.05
MOL File: 178876-82-9.mol

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METHYL 6-AMINO-5-BROMOPICOLINATE Property

Melting point:: 143-145 °C
Boiling point:: 359.2±37.0 °C(Predicted)
Density: 1.662
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: -0.23±0.10(Predicted)
Appearance: Light yellow to yellow Solid
InChI: InChI=1S/C7H7BrN2O2/c1-12-7(11)5-3-2-4(8)6(9)10-5/h2-3H,1H3,(H2,9,10)
InChIKey: OQUCMNQHZFOMPC-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)=NC(N)=C(Br)C=C1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: A601910
Product name: 6-Amino-5-bromopyridine-2-carboxylicAcidMethylEster
Packaging: 250mg
Price: $155
Updated: 2021/12/16

TRC

Product number: A601910
Product name: 6-Amino-5-bromopyridine-2-carboxylicAcidMethylEster
Packaging: 2.5g
Price: $1230
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17617
Product name: 6-Amino-5-bromopyridine-2-carboxylic acid methyl ester
Packaging: 250mg
Price: $130
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17617
Product name: 6-Amino-5-bromopyridine-2-carboxylic acid methyl ester
Packaging: 500mg
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17617
Product name: 6-Amino-5-bromopyridine-2-carboxylic acid methyl ester
Packaging: 1g
Price: $310
Updated: 2021/12/16

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METHYL 6-AMINO-5-BROMOPICOLINATE Chemical Properties,Usage,Production

Uses

Methyl 6-amino-5-bromopicolinate is used in the preparation of aminopyridinamides as sodium channel modulators.

Synthesis

36052-26-3

178876-83-0

178876-82-9

d) Synthesis of methyl 6-amino-5-bromopyridine-2-carboxylate: Methyl 6-aminopyridine-2-carboxylate (10 g, 66.0 mmol) was dissolved in chloroform (450 mL) at room temperature, and a chloroform (100 mL) solution of bromine (3.4 mL, 66.0 mmol) was slowly added. The reaction mixture was stirred for 40 hours, then diluted with chloroform and washed sequentially with saturated sodium thiosulfate solution and water. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure, and the residue was purified by silica gel column chromatography using ethyl acetate/hexane as eluent to afford methyl 5-bromo-6-aminopyridine-2-carboxylate as a yellow solid (3.3 g, 22% yield).MS ESI (m/e): 231.0 [(M + H)+].1H NMR (CDCl3, 400 MHz): δ ( ppm) = 7.76 (d, J = 7.88 Hz, 1H), 7.34 (d, J = 7.92 Hz, 1H), 5.23 (s, 2H), 3.94 (s, 3H). (d) Isolation of methyl 6-amino-3-bromopyridine-2-carboxylate: In step d), the isomer methyl 6-amino-3-bromopyridine-2-carboxylate was isolated as a by-product to give methyl 6-amino-3-bromopyridine-2-carboxylate (3.0 g, 19% yield).MS ESI (m/e): 231.2 [(M + H)+].1H NMR (CDCl3, 400 MHz): δ (ppm) = 7.60 (d , J = 8.72 Hz, 1H), 6.47 (d, J = 7.88 Hz, 1H), 4.71 (s, 2H), 3.94 (s, 3H).

References

[1] Journal of Organic Chemistry, 1996, vol. 61, # 14, p. 4623 - 4633
[2] Organic Process Research and Development, 2010, vol. 14, # 1, p. 263 - 271
[3] Tetrahedron Letters, 2010, vol. 51, # 38, p. 5035 - 5037
[4] Patent: US2011/190269, 2011, A1. Location in patent: Page/Page column 61-62
[5] Patent: WO2011/92272, 2011, A1. Location in patent: Page/Page column 129; 130

METHYL 6-AMINO-5-BROMOPICOLINATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 6-AMINO-5-BROMOPICOLINATE Suppliers

Canada 1 China 90 India 2 United Kingdom 1 United States 10 Global 104

Wuhan Luohua Medical Technology Co.,Ltd.

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View Lastest Price from METHYL 6-AMINO-5-BROMOPICOLINATE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: methyl 6-amino-5-bromo-pyridine-2-carboxylate 178876-82-9
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99% min
Supply Ability: 100kg
Release date: 2025-08-18

Shaanxi Dideu Medichem Co. Ltd

Product: METHYL 6-AMINO-5-BROMOPICOLINATE 178876-82-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

Career Henan Chemical Co

Product: METHYL 6-AMINO-5-BROMOPICOLINATE 178876-82-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-02

178876-82-9, METHYL 6-AMINO-5-BROMOPICOLINATERelated Search:

1,2,4-thiadiazol-5-amine 5-BROMOTHIAZOLE-2-CARBOXYLIC ACID ETHYL 5-BROMO-3-(2-CARBOXY-VINYL)-1H-INDOLE-2-CARBOXYLATE 5-bromo-6-pyrrolidin-1-ylnicotinic acid 5-Bromo-3H-spiro[isobenzofuran-1,4'-piperidin]-3-one hydrochloride 5-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE 1'-Benzyl-5-bromo-3H-spiro[isobenzofuran-1,4'-piperidin]-3-one METHYL 6-AMINO-5-BROMONICOTINATE 6-Bromo-3-methyl-pyridine-2-carboxylic acid methyl ester 6-CHLORO-2-FLUORO-NICOTINIC ACID METHYL ESTER Methyl 6-chloro-4-iodonicotinate Methyl 6-chloro-5-methylpyridine-3-carboxylate Methyl 6-chloro-4-Methylnicotinate Methyl 6-broMo-3-chloropicolinate Methyl 6-chloro-3-(trifluoroMethyl)picolinate Methyl6-(aminomethyl)pyridine-3-carboxylatehydrochloride Methyl 6-chloro-2-(Methylsulfonyl)pyriMidine-4-carboxylate 6-Chloro-3-fluoro-pyridine-2-carboxylic acid methyl ester

methyl 6-amino-5-bromopicolinate

6-AMino-5-broMopyridine-2-carboxylic Acid Methyl Ester

METHYL 6-AMINO-5-BROMOPYRIDINE-2-CARBOXYLATE

2-Pyridinecarboxylic acid, 6-amino-5-bromo-, methyl ester

METHYL 6-AMINO-5-BROMOPICOLINATE ISO 9001：2015 REACH

178876-82-9

C7H7N2O2Br

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