ChemicalBook > CAS DataBase List > 5-Bromo-2-methoxybenzonitrile
5-Bromo-2-methoxybenzonitrile
Uses- Product Name
- 5-Bromo-2-methoxybenzonitrile
- CAS No.
- 144649-99-0
- Chemical Name
- 5-Bromo-2-methoxybenzonitrile
- Synonyms
- ST5408714;Albb-008949;4-Bromo-2-cyanoanisole;5-Bromo-o-anisyl cyanide;-Bromo-o-anisyl cyanide;2-Methoxy-5-bromobenzonitrile;Benzonitrile, 5-broMo-2-Methoxy-;5-Bromo-2-methoxybenzonitrile 96%;5-Bromo-2-(methyloxy)benzonitrile;5-Bromo-2-methoxybenzonitrile >
- CBNumber
- CB71106575
- Molecular Formula
- C8H6BrNO
- Formula Weight
- 212.04
- MOL File
- 144649-99-0.mol
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5-Bromo-2-methoxybenzonitrile Property
- Melting point:
- 91-92 °C
- Boiling point:
- 287.8±20.0 °C(Predicted)
- Density
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- soluble in Methanol
- form
- powder to crystal
- color
- White to Yellow to Orange
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 701173
- Product name
- 5-Bromo-2-methoxybenzonitrile
- Purity
- 96%
- Packaging
- 5g
- Price
- $73
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- 701173
- Product name
- 5-Bromo-2-methoxybenzonitrile
- Purity
- 96%
- Packaging
- 25g
- Price
- $284
- Updated
- 2023/01/07
TCI Chemical
- Product number
- B3123
- Product name
- 5-Bromo-2-methoxybenzonitrile
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $110
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B3123
- Product name
- 5-Bromo-2-methoxybenzonitrile
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $424
- Updated
- 2025/07/31
TRC
- Product number
- B696613
- Product name
- 5-Bromo-2-methoxybenzonitrile
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
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5-Bromo-2-methoxybenzonitrile Chemical Properties,Usage,Production
Uses
5-Bromo-2-methoxybenzonitrile can be used as an organic and pharmaceutical intermediate. Halogenated benzonitrile is an important organic intermediate, mainly used in the preparation of pharmaceuticals and pesticides, and has wide applications in the manufacture of dyes, engineering plastics, and photosensitive materials.
Chemical Properties
off-white crystalline
Synthesis
6609-56-9
144649-99-0
General procedure for the synthesis of 2-methoxy-5-bromobenzonitrile from 2-methoxybenzonitrile: N-bromosuccinimide (NBS, 1.5 eq., 0.3 mmol), catalyst (10 mol%, 0.02 mmol), and acetonitrile (CH3CN, 1.0 mL) were added to the reaction tube, followed by 2-methoxybenzonitrile (0.2 mmol). The reaction mixture was stirred for 12 h at room temperature protected from light. Upon completion of the reaction, the reaction was quenched with saturated sodium thiosulfate (Na2S2O3) aqueous solution (2 mL). The reaction mixture was extracted with ethyl acetate (3.5 mL). The organic phases were combined, washed with brine (10 mL), dried over anhydrous sodium sulfate (Na2SO4) and filtered through a diatomaceous earth pad. The filtrate was concentrated under reduced pressure and the residue was purified by rapid chromatography on a silica gel column using petroleum ether/dichloromethane (5:1) as eluent to afford the target product 2-methoxy-5-bromobenzonitrile.
References
[1] Tetrahedron, 2017, vol. 73, # 50, p. 7105 - 7114
[2] Patent: US2009/203657, 2009, A1. Location in patent: Page/Page column 51
[3] Patent: US2009/203677, 2009, A1. Location in patent: Page/Page column 54
[4] Patent: US2009/197871, 2009, A1. Location in patent: Page/Page column 53-54
[5] Patent: WO2009/100169, 2009, A1. Location in patent: Page/Page column 132-133
5-Bromo-2-methoxybenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-2-methoxybenzonitrile manufacturers
Career Henan Chemical Co
- Product
- 5-Bromo-2-methoxybenzonitrile 144649-99-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-24
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