1-Bromo-4-chloro-2,5-difluorobenzene
- Product Name
- 1-Bromo-4-chloro-2,5-difluorobenzene
- CAS No.
- 172921-33-4
- Chemical Name
- 1-Bromo-4-chloro-2,5-difluorobenzene
- Synonyms
- 2,5-difluoro-4-chlorobromobenzene;4-chloro-2,5-difluorobromobenzene;5-Bromo-2-chloro-1,4-difluorobenzene;1-Bromo-4-chloro-2,5-difluorobenzene;Benzene, 1-bromo-4-chloro-2,5-difluoro-
- CBNumber
- CB71114549
- Molecular Formula
- C6H2BrClF2
- Formula Weight
- 227.43
- MOL File
- Mol file
1-Bromo-4-chloro-2,5-difluorobenzene Property
- Boiling point:
- 189℃
- Density
- 1.805
- Flash point:
- 68℃
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B685423
- Product name
- 1-Bromo-4-chloro-2,5-difluorobenzene
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B685423
- Product name
- 1-Bromo-4-chloro-2,5-difluorobenzene
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FB64547
- Product name
- 1-Bromo-4-chloro-2,5-difluorobenzene
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FB64547
- Product name
- 1-Bromo-4-chloro-2,5-difluorobenzene
- Packaging
- 2g
- Price
- $136
- Updated
- 2021/12/16
- Product number
- FB64547
- Product name
- 1-Bromo-4-chloro-2,5-difluorobenzene
- Packaging
- 5G
- Price
- $270
- Updated
- 2021/12/16
1-Bromo-4-chloro-2,5-difluorobenzene Chemical Properties,Usage,Production
Synthesis
2613-30-1
172921-33-4
2. Preparation of 1-bromo-4-chloro-2,5-difluorobenzene: Anhydrous copper(II) bromide (2.7 g, 12.1 mmol) and tert-butyl nitrite (1.56 g, 15.1 mmol) were dissolved in anhydrous acetonitrile (25 mL) under anhydrous conditions. The reaction mixture was heated to 65°C, followed by the slow dropwise addition of 4-chloro-2,5-difluoroaniline (1.65 g, 10.1 mmol) solution in anhydrous acetonitrile (2 mL), during which vigorous gas escape was observed. Upon completion of the reaction, the mixture was cooled to room temperature, poured into 2N HCl and extracted twice with ether. The organic phases were combined, washed sequentially with 2N HCl and saturated sodium bicarbonate solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by rapid chromatography on silica gel (eluent: hexane) to afford the target compound 1-bromo-4-chloro-2,5-difluorobenzene as a white solid (1.11 g, 48.4% yield).1H NMR (CDCl3) δ: 7.38 (dd, 2H), 7.21 (dd, 2H).
References
[1] Patent: US2009/88322, 2009, A1. Location in patent: Page/Page column 8
[2] Patent: US2009/62125, 2009, A1. Location in patent: Page/Page column 8
1-Bromo-4-chloro-2,5-difluorobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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