Fosfluconazole

Product Name: Fosfluconazole
CAS No.: 194798-83-9
Chemical Name: Fosfluconazole
Synonyms: Prodif;CS-969;Fosfluconazol;Fosfluconazole(INN);Fosfluconazole, >=98%;Dihydrogen phosphate ester;Fungal,Inhibitor,Fosfluconazole,inhibit;2-(2,4-difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)propyl dihydrogen phosphate;PHARMA PRODUCT FLUCONAZOLE USP 2-(2,4-DIFLUOROPHENYL)-1,3-BIS(1,2,4-TRIAZOL-1-YL) PROPAN-2-OL;2-(2,4-Difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)propan-2-yl dihydrogen phosphate (Efinaconazole?Impurity)
CBNumber: CB71120322
Molecular Formula: C13H13F2N6O4P
Formula Weight: 386.25
MOL File: 194798-83-9.mol

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Fosfluconazole Property

Melting point:: 223-224°
Boiling point:: 701.5±70.0 °C(Predicted)
Density: 1.70±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 6.2 mg/mL (16.05 mM)
form: Solid
pka: 1.44±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6032
Product name: Fosfluconazole
Purity: 98.08%
Packaging: 10mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-6032
Product name: Fosfluconazole
Purity: 98.08%
Packaging: 25mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-6032
Product name: Fosfluconazole
Purity: 98.08%
Packaging: 50mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-6032
Product name: Fosfluconazole
Purity: 98.08%
Packaging: 100mg
Price: $288
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002762
Product name: FOSFLUCONAZOLE
Purity: 95.00%
Packaging: 100MG
Price: $2317.35
Updated: 2021/12/16

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Fosfluconazole Chemical Properties,Usage,Production

Description

Fosfluconazole is a phosphate prodrug of fluconazole, and it was launched in Japan as an intravenous injection for the treatment of candidiasis and cryptococcosis infections. Fluconazole, a triazole antifungal agent, is a selective inhibitor of fungal cytochrome P450 sterol C-14 alpha-demethylation, and it is widely used for the treatment of patients with serious systemic fungal infections. Fluconazole is marketed in both oral and intravenous formulations, the latter being a dilute (2 mg/ mL) infusion in saline due to the relatively poor water solubility of the drug. In patients needing high doses (＞400 mg) of fluconazole, a drawback of the IV formulation is the requirement of a high-volume infusion, which is undesirable in critically ill patients in whom fluid overload must be avoided. Fosfluconazole is a prodrug with approximately 40-fold higher water solubility than fluconazole, thereby achieving a substantial reduction in infusion volume. It is prepared in three steps starting from fluconazole. In the first step, fluconazole is converted to its dibenzyl phosphite derivative by reaction with phosphorous trichloride and benzyl alcohol. Subsequent oxidation of the phosphite to the corresponding phosphate with hydrogen peroxide and cleavage of the benzyl protecting groups by hydrogenolysis affords fosfluconazole. In vitro, fosfluconazole is at least 25-fold less potent than fluconazole against single isolates of Candida species and Cryptococcus neoformans. In vivo, it is rapidly hydrolyzed to fluconazole by phosphatase enzymes and exhibits similar efficacy to fluconazole in experimental models of fungal disease. The hydrolysis potential of fosfluconazole was initially demonstrated in homogenates of kidney, lung and liver of rat, dog, and human. Subsequently, in clinical trials with healthy volunteers (n＝24), fosfluconazole was shown to hydrolyze rapidly and almost completely to provide a 97% mean bioavailability of fluconazole. Less than 1% of the administered dose of fosfluconazole was excreted unchanged in the urine, with the majority (85.6%) of the dose eliminated as fluconazole. The terminal half-life was about 2.3 hours, and the volume of distribution was 0.2 L/kg. The time to reach steady state drug levels with 500 mg daily dose was about 10 days, which could be shortened to 3 days by administering loading doses of 1000 mgs on days 1 and 2 followed by 500 mg daily. Further studies showed that hepatic or renal impairment did not significantly alter the pharmacokinetic profile of fosfluconazole. In phase III studies in patients with deep-seated mycosis due to Candida or Cryptococcus (n＝160), a 2-day loading dose regimen of fosfluconazole provided efficacy range of 73.8% (in Japanese patients) to 91.7% (patients of non-Japanese origin). The adverse events seen in these trials were similar to those previously known with fluconazole therapy and included rash (3.1%), abnormal liver function values (2.5%), asthma (1.9%), and lightheadedness (1.9%).

Originator

Pfizer (Japan)

Definition

ChEBI: Fosfluconazole is a member of triazoles, a triazole antifungal drug and a conazole antifungal drug. It has a role as a prodrug. It is functionally related to a fluconazole.

brand name

Prodif

Fosfluconazole Preparation Products And Raw materials

Raw materials

Preparation Products

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Fosfluconazole Suppliers

China 85 India 2 South Korea 1 United Kingdom 1 United States 10 Global 99

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

Abblis Chemicals LLC

Tel: --
Fax: --
Email: info@abblis.com
Country: United States
ProdList: 1272
Advantage: 0

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

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View Lastest Price from Fosfluconazole manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Fosfluconazole 194798-83-9
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-10-11

Career Henan Chemical Co

Product: Fosfluconazole 194798-83-9
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

194798-83-9, FosfluconazoleRelated Search:

Itraconazole Voriconazole Posaconazole Fosfluconazole

2-(2,4-difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)propyl dihydrogen phosphate

Prodif

Fosfluconazole, >=98%

PHARMA PRODUCT FLUCONAZOLE USP 2-(2,4-DIFLUOROPHENYL)-1,3-BIS(1,2,4-TRIAZOL-1-YL) PROPAN-2-OL

Dihydrogen phosphate ester

CS-969

Fosfluconazole(INN)

1H-1,2,4-Triazole-1-ethanol, α-(2,4-difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-, 1-(dihydrogen phosphate)

1H-1,2,4-Triazole-1-ethanol, a-(2,4-difluorophenyl)-a-(1H-1,2,4-triazol-1-ylmethyl)-,1-(dihydrogen phosphate)

Fungal,Inhibitor,Fosfluconazole,inhibit

2-(2,4-Difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)propan-2-yl dihydrogen phosphate (Efinaconazole?Impurity)

Fosfluconazol

194798-83-9

C13H13F2N6O4P

Amines

API

Chiral Reagents

Heterocycles