3-BROMO-2-IODOPHENOL

Application

Product Name: 3-BROMO-2-IODOPHENOL
CAS No.: 855836-52-1
Chemical Name: 3-BROMO-2-IODOPHENOL
Synonyms: 3-Bromo-2-iodopheno;3-BROMO-2-IODOPHENOL;2-iodine-3-bromophenol;Phenol, 3-bromo-2-iodo-
CBNumber: CB7112575
Molecular Formula: C6H4BrIO
Formula Weight: 298.9
MOL File: 855836-52-1.mol

More

Less

3-BROMO-2-IODOPHENOL Property

Melting point:: 85℃
Boiling point:: 243.9±20.0 °C(Predicted)
Density: 2.369±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: claggy looking crystalline powder
pka: 7.55±0.10(Predicted)
color: Off white (hint of cream & peach)
InChI: InChI=1S/C6H4BrIO/c7-4-2-1-3-5(9)6(4)8/h1-3,9H
InChIKey: WJJYPSTVJBRTGK-UHFFFAOYSA-N
SMILES: C1(O)=CC=CC(Br)=C1I

More

Less

Safety

HS Code: 2908190090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B683908
Product name: 3-Bromo-2-iodophenol
Packaging: 25mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B683908
Product name: 3-Bromo-2-iodophenol
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: OR400091
Product name: 3-Bromo-2-iodophenol
Packaging: 1g
Price: $131
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0063549
Product name: 3-BROMO-2-IODOPHENOL
Purity: 95.00%
Packaging: 5MG
Price: $497.08
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB167491
Product name: 3-Bromo-2-iodophenol
Packaging: 1g
Price: $500
Updated: 2021/12/16

More

Less

3-BROMO-2-IODOPHENOL Chemical Properties,Usage,Production

Application

2-Iodo-3-bromophenol can be used as a synthetic intermediate and a pharmaceutical intermediate, mainly in laboratory research and development processes and pharmaceutical and chemical production processes.

Synthesis

863870-79-5

855836-52-1

The general procedure for the synthesis of 2-iodo-3-bromophenol from 3-bromo-2-iodophenyl diethylcarbamate (3; 3.96 g, 10 mmol) was carried out as follows: to a solution of 3-bromo-2-iodophenyl diethylcarbamate in ethanol (EtOH, 100 mL) was added powdered sodium hydroxide (NaOH, 4.0 g, 100 mmol) in two portions. The reaction mixture was heated to reflux and maintained for 24 hours. The reaction progress was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature (r.t.) and the reaction was quenched with 2 M aqueous hydrochloric acid (HCl). The aqueous layer was extracted with ethyl acetate (EtOAc, 3 × 30 mL). The organic layers were combined, washed with saturated saline (brine) and dried with anhydrous sodium sulfate (Na2SO4). Subsequently, the solvent was removed by evaporation under reduced pressure. The crude product was purified by silica gel column chromatography using petroleum ether (PE)/ethyl acetate (EtOAc) (8:1) as eluent to afford the target product, 2-iodo-3-bromophenol, as a white solid; Yield: 2.66 g (89% yield); Melting point: 85-87 °C. The spectral data (1H NMR and 13C NMR) of compound 4 were in agreement with literature reports.1H NMR (400 MHz, CDCl3) δ= 7.20 (dd, J = 8.1, 1.5 Hz, 1H), 7.12 (t, J = 8.1 Hz, 1H), 6.92 (dd, J = 8.1, 1.5 Hz, 1H), 5.54 (br s, 1H ). 13C NMR (400 MHz, CDCl3) δ= 156.6, 130.8, 129.6, 125.0, 113.3, 94.4.

References

[1] Journal of Organic Chemistry, 2005, vol. 70, # 16, p. 6548 - 6551
[2] Synthesis (Germany), 2017, vol. 49, # 16, p. 3726 - 3730
[3] Journal of Organic Chemistry, 2007, vol. 72, # 14, p. 5113 - 5118
[4] Organic and Biomolecular Chemistry, 2010, vol. 8, # 17, p. 3860 - 3864
[5] Journal of Organic Chemistry, 2011, vol. 76, # 9, p. 3416 - 3437

3-BROMO-2-IODOPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3-BROMO-2-IODOPHENOL Suppliers

China 87 India 1 United Kingdom 3 United States 9 Global 100

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

Aagile Labs Division of Tyger Scientific

Tel: --
Fax: --
Email: tygersci@yahoo.com
Country: United States
ProdList: 6568
Advantage: 68

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

855836-52-1, 3-BROMO-2-IODOPHENOLRelated Search:

4-Iodophenol 2-Iodophenol AKOS B028910 3-BROMO-2-IODOPHENYL N,N-DIETHYLCARBAMATE 3,5-Dibromo-2-iodotrifluoromethoxybenzene 3-BROMO-2-IODOPHENOL

3-BROMO-2-IODOPHENOL

Phenol, 3-bromo-2-iodo-

3-Bromo-2-iodopheno

2-iodine-3-bromophenol

855836-52-1

pharmacetical