Pioglitazone

Product Name: Pioglitazone
CAS No.: 105355-27-9
Chemical Name: Pioglitazone
Synonyms: Pioglitazone;5-[[4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione;5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione;5-({4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}Methyl)-1,3-thiazolidine-2,4-dione hydrochloride
CBNumber: CB71177472
Molecular Formula: C19H20N2O3S
Formula Weight: 356.44
MOL File: 105355-27-9.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AHH

Product number: API-1393
Product name: Pioglitazone
Purity: 98%
Packaging: 5g
Price: $710
Updated: 2021/12/16

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Pioglitazone Chemical Properties,Usage,Production

Definition

ChEBI: Pioglitazone is a member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity. It has a role as an insulin-sensitizing drug, an EC 2.7.1.33 (pantothenate kinase) inhibitor, a xenobiotic, an EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor, a ferroptosis inhibitor, a cardioprotective agent, a PPARgamma agonist, an antidepressant, a geroprotector and a hypoglycemic agent. It is a member of thiazolidinediones, an aromatic ether and a member of pyridines.

Clinical Use

Treatment of type 2 diabetes mellitus

Metabolism

Pioglitazone undergoes extensive hepatic metabolism by hydroxylation mainly via cytochrome P450 2C8 to form active and inactive metabolites. Three of the six identified metabolites are active (M-II, M-III, and M-IV). Following oral administration of radiolabelled pioglitazone to man, recovered label was mainly in faeces (55%) and a lesser amount in urine (45%).

Pioglitazone Preparation Products And Raw materials

Raw materials

Preparation Products

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Pioglitazone Suppliers

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105355-27-9, PioglitazoneRelated Search:

DIETHOXYMETHANE Thiophanate-methyl Ethoxyquin Methyl salicylate Benzyltriethylammonium chloride Ethoxyethyne Gliquidone Troglitazone Ethyl vinyl ether Tribenuron methyl 2-Ethoxyethanol PHENYL VALERATE Methyl Methyl bromide Pioglitazone hydrochloride Pioglitazone Pioglitazone N-Oxide Pioglitazone, hydroxy M-IV,Hydroxy Pioglitazone (M-IV)

5-[[4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione

Pioglitazone

5-({4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}Methyl)-1,3-thiazolidine-2,4-dione hydrochloride

5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione

105355-27-9

105355279