Pioglitazone
- Product Name
- Pioglitazone
- CAS No.
- 105355-27-9
- Chemical Name
- Pioglitazone
- Synonyms
- Pioglitazone;5-[[4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione;5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione;5-({4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}Methyl)-1,3-thiazolidine-2,4-dione hydrochloride
- CBNumber
- CB71177472
- Molecular Formula
- C19H20N2O3S
- Formula Weight
- 356.44
- MOL File
- 105355-27-9.mol
N-Bromosuccinimide Price
- Product number
- API-1393
- Product name
- Pioglitazone
- Purity
- 98%
- Packaging
- 5g
- Price
- $710
- Updated
- 2021/12/16
Pioglitazone Chemical Properties,Usage,Production
Definition
ChEBI: Pioglitazone is a member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity. It has a role as an insulin-sensitizing drug, an EC 2.7.1.33 (pantothenate kinase) inhibitor, a xenobiotic, an EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor, a ferroptosis inhibitor, a cardioprotective agent, a PPARgamma agonist, an antidepressant, a geroprotector and a hypoglycemic agent. It is a member of thiazolidinediones, an aromatic ether and a member of pyridines.
Clinical Use
Treatment of type 2 diabetes mellitus
Metabolism
Pioglitazone undergoes extensive hepatic metabolism by hydroxylation mainly via cytochrome P450 2C8 to form active and inactive metabolites. Three of the six identified metabolites are active (M-II, M-III, and M-IV). Following oral administration of radiolabelled pioglitazone to man, recovered label was mainly in faeces (55%) and a lesser amount in urine (45%).
Pioglitazone Preparation Products And Raw materials
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