Yuanhuacine

Product Name: Yuanhuacine
CAS No.: 60195-70-2
Chemical Name: Yuanhuacine
Synonyms: YHL-14;Odoracin;Nsc261422;NSC 270919;From gnidia;Yuanhuacine;gnidilatidin;Stillingia factor S6;Gnidia B644130K130 origin;(22E,24E)-12β-Benzoyloxy-22,23,24,25-tetradehydrosimplexin
CBNumber: CB71180087
Molecular Formula: C37H44O10
Formula Weight: 648.74
MOL File: 60195-70-2.mol

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Yuanhuacine Property

Boiling point:: 765.9±60.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
pka: 11.00±0.70(Predicted)
form: Solid
color: White to off-white
InChIKey: CGSGRJNIABXQJQ-NSCQCFIPSA-N
SMILES: O1[C@@]2(C(C)=C)[C@H](OC(=O)C3=CC=CC=C3)[C@@H](C)[C@@]34O[C@]1(/C=C/C=C/CCCCC)O[C@]2([H])[C@]3([H])[C@]1([H])O[C@]1(CO)[C@@H](O)[C@@]1(O)[C@@]4([H])C=C(C)C1=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PXT0002380
Product name: YUANHUACINE
Purity: 95.00%
Packaging: 5MG
Price: $500.06
Updated: 2021/12/16

Arctom

Product number: SY232713
Product name: Yuanhuacine
Purity: ≥98%
Packaging: 10mg
Price: $1816.36
Updated: 2021/12/16

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Yuanhuacine Chemical Properties,Usage,Production

Uses

Yuanhuacine (Gnidilatidin), a diterpene from Daphne genkwa, is an effective and highly selective inhibitor of the basal-like 2 (BL2) subtype of TNBC. Yuanhuacine can induce G2/M cell cycle arrest and has broad anti-tumor activity. Yuanhuacine is an orally active DNA damaging agent[1][2][3].

in vivo

Yuanhuacine (0.5-1 mg/kg, oral, once daily, 21 days) inhibits tumor proliferation in mice^[1].

Animal Model:	H1993 cells implanted xenograft mouse model^[1]
Dosage:	0.5, 1 mg/kg; daily; 21 days
Administration:	Oral
Result:	Inhibited tumor growth by 33.4% and 38.8%, respectively, reduced tumor weight, activated AMPK, and inhibited proliferation biomarkers Ki-67 and PCNA in tumor tissues.

References

[1] Ji In Kang, et al. Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells. PLoS One. 2015 Dec 11;10(12):e0144368. DOI:10.1371/journal.pone.0144368
[2] Ruowen Zhang, et al. The Chinese herb isolate yuanhuacine (YHL-14) induces G2/M arrest in human cancer cells by up-regulating p21 protein expression through an p53 protein-independent cascade. J Biol Chem. 2014 Mar 7;289(10):6394-403. DOI:10.1074/jbc.M113.513960
[3] Charles S Fermaintt, et al. Yuanhuacine Is a Potent and Selective Inhibitor of the Basal-Like 2 Subtype of Triple Negative Breast Cancer with Immunogenic Potential. Cancers (Basel). 2021 Jun 7;13(11):2834. DOI:10.3390/cancers13112834

Yuanhuacine Preparation Products And Raw materials

Raw materials

Preparation Products

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Yuanhuacine Suppliers

China 39 Germany 1 United States 2 Global 42

Chengdu DeSiTe Biological Technology Co., Ltd

Tel: 17308096051
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Chengdu Biopurify Phytochemicals Ltd.

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Shanghai Tauto Biotech Co., Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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Shanghai Yihe Biological Technology Co., Ltd.

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Career Henan Chemica Co

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60195-70-2, YuanhuacineRelated Search:

Breviscapinun VERATRINE Artemisinin Panax notoginsenosides Andrographolide 4',5-DIHYDROXY-7-METHOXYFLAVONE Yuanhuanin Yuankanin Yubeinine 6H-2,8b-Epoxyoxireno[6,7]azuleno[5,4-e]-1,3-benzodioxol-6-one, 10-(acetyloxy)-3a,3b,3c,4a,5,5a,8a,9,10,10a-decahydro-5,5a-dihydroxy-4a-(hydroxymethyl)-7,9-dimethyl-10a-(1-methylethenyl)-2-phenyl-, (2S,3aR,3bS,3cS,4aR,5S,5aS,8aR,8bR,9R,10R,10aS)- yuanamide YU238259 yuanhunine yuanhuadine 2-METHOXY-1,3-DIOXOLANE TRIBUTYL ORTHOFORMATE 2-Vinyl-1,3-dioxolane Triethyl orthoacetate

Yuanhuacine

gnidilatidin

(22E,24E)-12β-Benzoyloxy-22,23,24,25-tetradehydrosimplexin

Odoracin

From gnidia

Gnidia B644130K130 origin

Nsc261422

NSC 270919

Stillingia factor S6

YHL-14

6alpha,7alpha-Epoxy-5beta-hydroxy-9,13,14-ortho-[(2E,4E)-deca-2,4-dien-1-yl]resiniferonol-12beta-yl benzoate

6H-2,8b-Epoxyoxireno[6,7]azuleno[5,4-e]-1,3-benzodioxol-6-one, 10-(benzoyloxy)-3a,3b,3c,4a,5,5a,8a,9,10,10a-decahydro-5,5a-dihydroxy-4a-(hydroxymethyl)-7,9-dimethyl-10a-(1-methylethenyl)-2-(1E,3E)-1,3-nonadien-1-yl-, (2S,3aR,3bS,3cS,4aR,5S,5aS,8aR,8bR,9R,10R,10aS)-

60195-70-2

C37H44O10