2-Difluoromethyl-1H-benzoimidazole
- Product Name
- 2-Difluoromethyl-1H-benzoimidazole
- CAS No.
- 705-09-9
- Chemical Name
- 2-Difluoromethyl-1H-benzoimidazole
- Synonyms
- EOS-60796;2-(Difluoromethyl);2-Difluoromethylbenzimidazole;2-Difluoromethyl-1H-benzoimidazole;2-(Difluoromethyl)-1H-benzimidazole;1H-Benzimidazole, 2-(difluoromethyl)-;2-(difluoroMethyl)-1H-1,3-benzodiazole;Octanedioicacid,3,10-dioxo-,dimethylester;1H-Benzimidazole,2-(difluoromethyl)-(9CI);1H-benzo[d]imidazole, 2-(difluoromethyl)-
- CBNumber
- CB71216072
- Molecular Formula
- C8H6F2N2
- Formula Weight
- 168.14
- MOL File
- 705-09-9.mol
2-Difluoromethyl-1H-benzoimidazole Property
- Melting point:
- 155.0 to 159.0 °C
- Boiling point:
- 57-62 °C(Press: 5 Torr)
- Density
- 1.366±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 10.43±0.10(Predicted)
- color
- White to Light yellow to Light orange
- λmax
- 276nm(EtOH)(lit.)
- InChI
- InChI=1S/C8H6F2N2/c9-7(10)8-11-5-3-1-2-4-6(5)12-8/h1-4,7H,(H,11,12)
- InChIKey
- PURNIHSRWGYONZ-UHFFFAOYSA-N
- SMILES
- C1(C(F)F)NC2=CC=CC=C2N=1
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D4763
- Product name
- 2-(Difluoromethyl)benzimidazole
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $43
- Updated
- 2025/07/31
- Product number
- D4763
- Product name
- 2-(Difluoromethyl)benzimidazole
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $130
- Updated
- 2025/07/31
- Product number
- D452253
- Product name
- 2-(Difluoromethyl)-1H-benzo[d]imidazole
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D452253
- Product name
- 2-(Difluoromethyl)-1H-benzo[d]imidazole
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 3H32-3-02
- Product name
- 2-(Difluoromethyl)-1H-benzimidazole
- Purity
- 97%
- Packaging
- 5G
- Price
- $85
- Updated
- 2021/12/16
2-Difluoromethyl-1H-benzoimidazole Chemical Properties,Usage,Production
Synthesis
381-73-7
95-54-5
705-09-9
In a screw cap vial, o-phenylenediamine (1 mmol) was dissolved in difluoroacetic acid (2 mL, 0.5 M) and the reaction mixture was stirred at 70 °C for 16 hours. After completion of the reaction, the difluoroacetic acid was removed by evaporation under reduced pressure and the crude product was purified by silica gel column chromatography to afford 2-(difluoromethyl)-1H-benzo[d]imidazole.
References
[1] Tetrahedron Letters, 2013, vol. 54, # 3, p. 201 - 204
[2] Patent: US2007/244110, 2007, A1. Location in patent: Page/Page column 4
[3] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 2, p. 206 - 210
[4] Tetrahedron Letters, 2007, vol. 48, # 18, p. 3251 - 3254
[5] Patent: WO2013/123634, 2013, A1. Location in patent: Paragraph 0027
2-Difluoromethyl-1H-benzoimidazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Difluoromethyl-1H-benzoimidazole manufacturers
- Product
- 2-Difluoromethyl-1H-benzoimidazole 705-09-9
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-01-12