ChemicalBook > CAS DataBase List > 2-Difluoromethyl-1H-benzoimidazole

2-Difluoromethyl-1H-benzoimidazole

Product Name
2-Difluoromethyl-1H-benzoimidazole
CAS No.
705-09-9
Chemical Name
2-Difluoromethyl-1H-benzoimidazole
Synonyms
EOS-60796;2-(Difluoromethyl);2-Difluoromethylbenzimidazole;2-Difluoromethyl-1H-benzoimidazole;2-(Difluoromethyl)-1H-benzimidazole;1H-Benzimidazole, 2-(difluoromethyl)-;2-(difluoroMethyl)-1H-1,3-benzodiazole;Octanedioicacid,3,10-dioxo-,dimethylester;1H-Benzimidazole,2-(difluoromethyl)-(9CI);1H-benzo[d]imidazole, 2-(difluoromethyl)-
CBNumber
CB71216072
Molecular Formula
C8H6F2N2
Formula Weight
168.14
MOL File
705-09-9.mol
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2-Difluoromethyl-1H-benzoimidazole Property

Melting point:
155.0 to 159.0 °C
Boiling point:
57-62 °C(Press: 5 Torr)
Density 
1.366±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
10.43±0.10(Predicted)
color 
White to Light yellow to Light orange
λmax
276nm(EtOH)(lit.)
InChI
InChI=1S/C8H6F2N2/c9-7(10)8-11-5-3-1-2-4-6(5)12-8/h1-4,7H,(H,11,12)
InChIKey
PURNIHSRWGYONZ-UHFFFAOYSA-N
SMILES
C1(C(F)F)NC2=CC=CC=C2N=1
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D4763
Product name
2-(Difluoromethyl)benzimidazole
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$43
Updated
2025/07/31
TCI Chemical
Product number
D4763
Product name
2-(Difluoromethyl)benzimidazole
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$130
Updated
2025/07/31
TRC
Product number
D452253
Product name
2-(Difluoromethyl)-1H-benzo[d]imidazole
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
D452253
Product name
2-(Difluoromethyl)-1H-benzo[d]imidazole
Packaging
100mg
Price
$60
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-3-02
Product name
2-(Difluoromethyl)-1H-benzimidazole
Purity
97%
Packaging
5G
Price
$85
Updated
2021/12/16
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2-Difluoromethyl-1H-benzoimidazole Chemical Properties,Usage,Production

Synthesis

381-73-7

95-54-5

705-09-9

In a screw cap vial, o-phenylenediamine (1 mmol) was dissolved in difluoroacetic acid (2 mL, 0.5 M) and the reaction mixture was stirred at 70 °C for 16 hours. After completion of the reaction, the difluoroacetic acid was removed by evaporation under reduced pressure and the crude product was purified by silica gel column chromatography to afford 2-(difluoromethyl)-1H-benzo[d]imidazole.

References

[1] Tetrahedron Letters, 2013, vol. 54, # 3, p. 201 - 204
[2] Patent: US2007/244110, 2007, A1. Location in patent: Page/Page column 4
[3] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 2, p. 206 - 210
[4] Tetrahedron Letters, 2007, vol. 48, # 18, p. 3251 - 3254
[5] Patent: WO2013/123634, 2013, A1. Location in patent: Paragraph 0027

2-Difluoromethyl-1H-benzoimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Difluoromethyl-1H-benzoimidazole manufacturers

Career Henan Chemical Co
Product
2-Difluoromethyl-1H-benzoimidazole 705-09-9
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2020-01-12

705-09-9, 2-Difluoromethyl-1H-benzoimidazoleRelated Search:

FENAZAFLOR 2-(Trifluoromethyl)benzimidazole 5-Nitro-2-trifluoromethylbenzimidazole 2-Difluoromethyl-1H-benzoimidazole 2-(HEPTAFLUOROPROPYL)BENZIMIDAZOLE 1H-BENZIMIDAZOLE, 6-BROMO-2-(TRIFLUOROMETHYL)- 1H-Benzimidazole,5-methyl-2-(trifluoromethyl)-(9CI) 4,5,6,7-tetrachloro-2-trifluoromethylbenzimidazole 1-BENZYL-2-(TRIFLUOROMETHYL)-5-(METHYLSULPHONYL)-(1H)-BENZIMIDAZOLE 1-ETHYL-2-(TRIFLUOROMETHYL)-1H-1,3-BENZIMIDAZOLE ZERENEX E/6010068 1-METHYL-2-(TRIFLUOROMETHYL)-1H-1,3-BENZIMIDAZOLE 1-ISOPROPYL-5-(METHYLSULPHONYL)-2-(TRIFLUOROMETHYL)-(1H)-BENZIMIDAZOLE 6-METHYL-2-(TRIFLUOROMETHYL)-1H-BENZIMIDAZOLE 6-NITRO-2-TRIFLUOROMETHYL-1H-BENZOIMIDAZOLE AURORA 2466 2-TRIFLUOROMETHYL-3 H-BENZOIMIDAZOL-5-YLAMINE

  • 1H-benzo[d]imidazole, 2-(difluoromethyl)-
  • 2-(Difluoromethyl)
  • 1H-Benzimidazole,2-(difluoromethyl)-(9CI)
  • 2-Difluoromethyl-1H-benzoimidazole
  • 2-(difluoromethyl)-1H-benzimidazole(SALTDATA: FREE)
  • 2-(Difluoromethyl)-1H-benzimidazole
  • 2-(difluoroMethyl)-1H-1,3-benzodiazole
  • 2-Difluoromethylbenzimidazole
  • EOS-60796
  • 1H-Benzimidazole, 2-(difluoromethyl)-
  • Octanedioicacid,3,10-dioxo-,dimethylester
  • 2-Benzofurancarboxylicacid,8-amino-,ethylester
  • 705-09-9
  • BENZIMIDAZOLE