ChemicalBook > CAS DataBase List > PD 145065
PD 145065
- Product Name
- PD 145065
- CAS No.
- 153049-49-1
- Chemical Name
- PD 145065
- Synonyms
- PD 145065;Ac-bhg-Leu-Asp-Ile-Ile-Trp;AC-DBHG-LEU-ASP-ILE-ILE-TRP;AC-D-BHG-LEU-ASP-ILE-ILE-TRP-OH;[AC-DBHG16] ENDOTHELIN-1 (16-21);Et receptor antagonist (Pd 145065);endothelin receptor antagonist*pd 145065;N-Acetyl-α-[10,11-Dihydro-5H-dibenzo[a,d]cycloheptadien-5-yl]-D-Gly-Leu-Asp-Ile-Ile-Trp;L-Tryptophan, N-[N-[N-[N-[N-[N-acetyl-D-2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)glycyl]-L-leucyl]-L-α-aspartyl]-L-isoleucyl]-L-isoleucyl]- (9CI)
- CBNumber
- CB7124466
- Molecular Formula
- C52H67N7O10
- Formula Weight
- 950.13
- MOL File
- 153049-49-1.mol
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PD 145065 Property
- storage temp.
- −20°C
- solubility
- phosphate buffer, pH 7.5: 1mg/mL
- form
- White solid
- color
- white
- Sequence
- Ac-{D-Bhg}-Leu-Asp-Ile-Ile-Trp-OH (Bhg = 5H-dibenzo[a,d]cycloheptene-5-glycine)
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 513020
- Product name
- PD 145065 - CAS 153049-49-1 - Calbiochem
- Packaging
- 500μG
- Price
- $166
- Updated
- 2022/05/15
American Custom Chemicals Corporation
- Product number
- PEP0001322
- Product name
- PD 145065
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $606.6
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- PEP0001322
- Product name
- PD 145065
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $794.86
- Updated
- 2021/12/16
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PD 145065 Chemical Properties,Usage,Production
Uses
PD 145065 is a highly potent but non-selective endothelin receptor antagonist with an IC50 value of 4 nM for the ETA receptor for rabbit renal artery vascular smooth muscle cells[1].
Biological Activity
Cell permeable: no', 'Primary Target
Endothelin receptor antagonist', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 4 nM against endothelin receptor (ETA receptor) in rabbit renal artery vascular smooth muscle cells; 15 nM for the ETB receptor (r at cerebellum)
References
[1] Warner TD, et al. Reversal of established responses to endothelin-1 in vivo and in vitro by the endothelin receptor antagonists, BQ-123 and PD 145065. Br J Pharmacol. 1994 May;112(1):207-13. DOI:10.1111/j.1476-5381.1994.tb13053.x
PD 145065 Preparation Products And Raw materials
Raw materials
Preparation Products
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153049-49-1, PD 145065Related Search:
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