PD 145065

Product Name: PD 145065
CAS No.: 153049-49-1
Chemical Name: PD 145065
Synonyms: PD 145065;Ac-bhg-Leu-Asp-Ile-Ile-Trp;AC-DBHG-LEU-ASP-ILE-ILE-TRP;AC-D-BHG-LEU-ASP-ILE-ILE-TRP-OH;[AC-DBHG16] ENDOTHELIN-1 (16-21);Et receptor antagonist (Pd 145065);endothelin receptor antagonist*pd 145065;N-Acetyl-α-[10,11-Dihydro-5H-dibenzo[a,d]cycloheptadien-5-yl]-D-Gly-Leu-Asp-Ile-Ile-Trp;L-Tryptophan, N-[N-[N-[N-[N-[N-acetyl-D-2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)glycyl]-L-leucyl]-L-α-aspartyl]-L-isoleucyl]-L-isoleucyl]- (9CI)
CBNumber: CB7124466
Molecular Formula: C52H67N7O10
Formula Weight: 950.13
MOL File: 153049-49-1.mol

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PD 145065 Property

storage temp.: −20°C
solubility: phosphate buffer, pH 7.5: 1mg/mL
form: White solid
color: white
Sequence: Ac-{D-Bhg}-Leu-Asp-Ile-Ile-Trp-OH (Bhg = 5H-dibenzo[a,d]cycloheptene-5-glycine)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 513020
Product name: PD 145065 - CAS 153049-49-1 - Calbiochem
Packaging: 500μG
Price: $166
Updated: 2022/05/15

American Custom Chemicals Corporation

Product number: PEP0001322
Product name: PD 145065
Purity: 95.00%
Packaging: 1MG
Price: $606.6
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0001322
Product name: PD 145065
Purity: 95.00%
Packaging: 5MG
Price: $794.86
Updated: 2021/12/16

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PD 145065 Chemical Properties,Usage,Production

Uses

PD 145065 is a highly potent but non-selective endothelin receptor antagonist with an IC50 value of 4 nM for the ETA receptor for rabbit renal artery vascular smooth muscle cells[1].

Biological Activity

Cell permeable: no', 'Primary Target
Endothelin receptor antagonist', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 4 nM against endothelin receptor (ETA receptor) in rabbit renal artery vascular smooth muscle cells; 15 nM for the ETB receptor (r at cerebellum)

References

[1] Warner TD, et al. Reversal of established responses to endothelin-1 in vivo and in vitro by the endothelin receptor antagonists, BQ-123 and PD 145065. Br J Pharmacol. 1994 May;112(1):207-13. DOI:10.1111/j.1476-5381.1994.tb13053.x

PD 145065 Preparation Products And Raw materials

Raw materials

Preparation Products

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PD 145065 Suppliers

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153049-49-1, PD 145065Related Search:

PD 145065 PD 156252 (S)-(-)-1,1-DIPHENYL-2-AMINOPROPANE PD 142893 10,11-DIHYDRO-5 H-DIBENZO[A,D]CYCLOHEPTENE 5-AMINOMETHYL-DIBENZOSUBERANE

[AC-DBHG16] ENDOTHELIN-1 (16-21)

AC-DBHG-LEU-ASP-ILE-ILE-TRP

AC-D-BHG-LEU-ASP-ILE-ILE-TRP-OH

PD 145065

endothelin receptor antagonist*pd 145065

Ac-bhg-Leu-Asp-Ile-Ile-Trp

N-Acetyl-α-[10,11-Dihydro-5H-dibenzo[a,d]cycloheptadien-5-yl]-D-Gly-Leu-Asp-Ile-Ile-Trp

L-Tryptophan, N-[N-[N-[N-[N-[N-acetyl-D-2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)glycyl]-L-leucyl]-L-α-aspartyl]-L-isoleucyl]-L-isoleucyl]- (9CI)

Et receptor antagonist (Pd 145065)

153049-49-1

C52H67N7O10

C52H65N7O10