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Jacobine.

Product Name
Jacobine.
CAS No.
6870-67-3
Chemical Name
Jacobine.
Synonyms
Jacobine.;NSC-89936;Jacobine-RM;(20S)-15α,20-Epoxy-15,20-dihydro-12-hydroxysenecionan-11,16-dione;(15R,20S)-15,20-Dihydro-15,20-epoxy-12-hydroxysenecionan-11,16-dione;Spiro[[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-3(2H),2'-oxirane]-2,7(4H)-dione, 5,6,9,11,13,14,14a,14b-octahydro-6-hydroxy-3',5,6-trimethyl-, (2'S,3'S,5R,6R,14aR,14bR)-
CBNumber
CB71248363
Molecular Formula
C18H25NO6
Formula Weight
351.39
MOL File
6870-67-3.mol
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Jacobine. Property

Melting point:
228°C
Boiling point:
485.2°C (rough estimate)
Density 
1.2737 (rough estimate)
refractive index 
1.5100 (estimate)
pka
12.89±0.60(Predicted)
IARC
3 (Vol. 10, Sup 7) 1987
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Safety

RIDADR 
1544
HazardClass 
6.1(b)
PackingGroup 
III
Hazardous Substances Data
6870-67-3(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
J210395
Product name
Jacobine
Packaging
0.25mg
Price
$160
Updated
2021/12/16
TRC
Product number
J210395
Product name
Jacobine
Packaging
0.5mg
Price
$305
Updated
2021/12/16
TRC
Product number
J210395
Product name
Jacobine
Packaging
1mg
Price
$570
Updated
2021/12/16
Biosynth Carbosynth
Product number
BJ161539
Product name
Jacobine
Packaging
10mg
Price
$900
Updated
2021/12/16
Biosynth Carbosynth
Product number
BJ161539
Product name
Jacobine
Packaging
25mg
Price
$1875
Updated
2021/12/16
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Jacobine. Chemical Properties,Usage,Production

Description

This alkaloid of the pyrrolizidine group of bases occurs in Senecio cineraria D.C., S. crucifolia and S. Jacobea. It is a laevorotatory base with [α]17D - 46.3° (CHCl 3 ). The alkaloid forms crystalline salts and derivatives, e.g. the hydrochloride, m.p. 220°C; [α]19D - 14.3° (H20); nitrate, m.p. 234°C; methiodide, m.p. 255°C and the picrate, m.p. 180°C which is soluble in H20. The alkaloid contains two active hydrogens and on alkaline hydrolysis yields retronecine and jaconecic acid, ClOH16 0 6, m.p. 182°C; [α]25D + 31.7° containing three O-methyl groups

Uses

Jacobine is a pyrrolizidine alkaloid which has been shown to be an herbivore insect deterrent and may be used in the protection of vegetation. Extracted from Crassocephalum plant of West Africa.

Definition

ChEBI: Jacobine is a pyrrolizine alkaloid.

References

Manske., Can. J. Res., 5,651 (1931)
Hosking, Brandt., New Zealand J. Sci. Tech., 14,638 (1936)
Blackie.,Pharrn. J., 138,102 (1937)
Barger, Blackie., J. Chern. Soc., 584 (1937)
Bradbury, Willis., Austral. J. Chern., 9,258 (1956)
Geissman., ibid, 12,247 (1959)
Bradbury, Masamune., J. Arner. Chern. Soc., 81,5201 (1959)
Masamune., ibid, 82, 5253 (1960)
Freidrichsons, Mathieson, Sutor., Tetrahedron Lett., 35 (1960)

Jacobine. Preparation Products And Raw materials

Raw materials

Preparation Products

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Jacobine. Suppliers

China 20 France 1 India 2 United Kingdom 1 United States 4 Global 28
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58

6870-67-3, Jacobine.Related Search:


  • Jacobine.
  • (15R,20S)-15,20-Dihydro-15,20-epoxy-12-hydroxysenecionan-11,16-dione
  • (20S)-15α,20-Epoxy-15,20-dihydro-12-hydroxysenecionan-11,16-dione
  • NSC-89936
  • Spiro[[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-3(2H),2'-oxirane]-2,7(4H)-dione, 5,6,9,11,13,14,14a,14b-octahydro-6-hydroxy-3',5,6-trimethyl-, (2'S,3'S,5R,6R,14aR,14bR)-
  • Jacobine-RM
  • 6870-67-3
  • C8H25NO6