Jacobine.
- Product Name
- Jacobine.
- CAS No.
- 6870-67-3
- Chemical Name
- Jacobine.
- Synonyms
- Jacobine.;NSC-89936;Jacobine-RM;(20S)-15α,20-Epoxy-15,20-dihydro-12-hydroxysenecionan-11,16-dione;(15R,20S)-15,20-Dihydro-15,20-epoxy-12-hydroxysenecionan-11,16-dione;Spiro[[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-3(2H),2'-oxirane]-2,7(4H)-dione, 5,6,9,11,13,14,14a,14b-octahydro-6-hydroxy-3',5,6-trimethyl-, (2'S,3'S,5R,6R,14aR,14bR)-
- CBNumber
- CB71248363
- Molecular Formula
- C18H25NO6
- Formula Weight
- 351.39
- MOL File
- 6870-67-3.mol
Jacobine. Property
- Melting point:
- 228°C
- Boiling point:
- 485.2°C (rough estimate)
- Density
- 1.2737 (rough estimate)
- refractive index
- 1.5100 (estimate)
- pka
- 12.89±0.60(Predicted)
- IARC
- 3 (Vol. 10, Sup 7) 1987
Safety
- RIDADR
- 1544
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 6870-67-3(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- J210395
- Product name
- Jacobine
- Packaging
- 0.25mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- J210395
- Product name
- Jacobine
- Packaging
- 0.5mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- J210395
- Product name
- Jacobine
- Packaging
- 1mg
- Price
- $570
- Updated
- 2021/12/16
- Product number
- BJ161539
- Product name
- Jacobine
- Packaging
- 10mg
- Price
- $900
- Updated
- 2021/12/16
- Product number
- BJ161539
- Product name
- Jacobine
- Packaging
- 25mg
- Price
- $1875
- Updated
- 2021/12/16
Jacobine. Chemical Properties,Usage,Production
Description
This alkaloid of the pyrrolizidine group of bases occurs in Senecio cineraria D.C., S. crucifolia and S. Jacobea. It is a laevorotatory base with [α]17D - 46.3° (CHCl 3 ). The alkaloid forms crystalline salts and derivatives, e.g. the hydrochloride, m.p. 220°C; [α]19D - 14.3° (H20); nitrate, m.p. 234°C; methiodide, m.p. 255°C and the picrate, m.p. 180°C which is soluble in H20. The alkaloid contains two active hydrogens and on alkaline hydrolysis yields retronecine and jaconecic acid, ClOH16 0 6, m.p. 182°C; [α]25D + 31.7° containing three O-methyl groups
Uses
Jacobine is a pyrrolizidine alkaloid which has been shown to be an herbivore insect deterrent and may be used in the protection of vegetation. Extracted from Crassocephalum plant of West Africa.
Definition
ChEBI: Jacobine is a pyrrolizine alkaloid.
References
Manske., Can. J. Res., 5,651 (1931)
Hosking, Brandt., New Zealand J. Sci. Tech., 14,638 (1936)
Blackie.,Pharrn. J., 138,102 (1937)
Barger, Blackie., J. Chern. Soc., 584 (1937)
Bradbury, Willis., Austral. J. Chern., 9,258 (1956)
Geissman., ibid, 12,247 (1959)
Bradbury, Masamune., J. Arner. Chern. Soc., 81,5201 (1959)
Masamune., ibid, 82, 5253 (1960)
Freidrichsons, Mathieson, Sutor., Tetrahedron Lett., 35 (1960)
Jacobine. Preparation Products And Raw materials
Raw materials
Preparation Products
Jacobine. Suppliers
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