NSC63925

Product Name: NSC63925
CAS No.: 20261-85-2
Chemical Name: NSC63925
Synonyms: NSC63925;AKD 1C, S 3466A;5,23-Didemethyl-5,23-diethylnonactin;4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone, 5,23-diethyl-2,11,14,20,29,32-hexamethyl-, (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-
CBNumber: CB71251059
Molecular Formula: C42H68O12
Formula Weight: 764.98
MOL File: 20261-85-2.mol

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NSC63925 Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: film

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20752
Product name: Dinactin
Purity: ≥95%
Packaging: 1mg
Price: $399
Updated: 2024/03/01

Cayman Chemical

Product number: 20752
Product name: Dinactin
Purity: ≥95%
Packaging: 5mg
Price: $998
Updated: 2024/03/01

TRC

Product number: D479728
Product name: Dinactin
Packaging: 2.5mg
Price: $3600
Updated: 2021/12/16

ApexBio Technology

Product number: C3454
Product name: Dinactin
Packaging: 5mg
Price: $1626
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PRO0004291
Product name: DINACTIN
Purity: 95.00%
Packaging: 1MG
Price: $686.7
Updated: 2021/12/16

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NSC63925 Chemical Properties,Usage,Production

Description

Dinactin is a macrotetrolide antibiotic that acts as an ionophore for monovalent cations, such as K⁺, NH₄⁺, and Rb⁺. It is commonly used to study membrane properties. Dinactin is a component of a macrotetralide-rich antifungal mixture produced by Streptomyces. Dinactin inhibits T-cell proliferation and cytokine production in vitro and reduces pulmonary eosinophilia in antigen-challenged mice.

Uses

Dinactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. It is a monovalent cation ionophore with high selectivity for ammonium and potassium. Dinactin inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-γ. Dinactin has not previously been available for intensive investigation.

Uses

Dinactin is a hydrophobic cyclic ester that inhibits T-cell proliferation induced by IL-2.

in vitro

dinactin inhibited t-cell proliferation induced by il-2, by mab to cd3, and by mabs to cd3 plus α-cd28 with identical dose-response curves. the ic50 was 10–20 ng/ml. dinactin inhibited cytokine production with ic50 values of 10 ng/ml for il-4 and il-5, 30 or 60 ng/ml for interferong or il-2, respectively [3].dinactin inhibited cytokine production through a post-transcriptional mechanism. dinactin also reduced pulmonary eosinophilia when administered within 1 d of airway antigen challenge [3].

References

[1] laprade r, grenier f, pagé-dansereau m, et al. carrier-mediated ion transport in lipid bilayer membranes[j]. canadian journal of biochemistry and cell biology, 1984, 62(8): 738-751.
[2] silva l j, crevelin e j, souza w r, et al. streptomyces araujoniae produces a multiantibiotic complex with ionophoric properties to control botrytis cinerea[j]. phytopathology, 2014, 104(12): 1298-1305.
[3] umland s p, shah h, jakway j p, et al. effects of cyclosporin a and dinactin on t-cell proliferation, interleukin-5 production, and murine pulmonary inflammation[j]. american journal of respiratory cell and molecular biology, 1999, 20(3): 481-492.

NSC63925 Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC63925 Suppliers

China 9 France 1 Germany 1 India 1 South Korea 1 Switzerland 1 United Kingdom 2 United States 6 Global 22

Lynnchem

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Shenzhen Polymeri Biochemical Technology Co., Ltd.

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BOC Sciences

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Meng Cheng Technology (Shanghai) Co., LTD

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Energy Chemical

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Shanghai Yifei Biotechnology Co. , Ltd.

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Nanjing Shizhou Biology Technology Co.,Ltd

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20261-85-2, NSC63925Related Search:

tetranactin trinactin TETRAHYDROFURAN-2-ACETIC ACID ETHYL ESTER monactin NSC63925

NSC63925

5,23-Didemethyl-5,23-diethylnonactin

AKD 1C, S 3466A

4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone, 5,23-diethyl-2,11,14,20,29,32-hexamethyl-, (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-

20261-85-2