ChemicalBook > CAS DataBase List > 1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one

1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one

Product Name
1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one
CAS No.
188116-07-6
Chemical Name
1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one
Synonyms
CS-1057;ELB-138;Imepitoin;AWD 131-13;AWD 131-138, >=98%;IMEPITOIN; AWD131-138;AWD 131-138(Imepitoin);Imepitoin, 10 mM in DMSO;3-(4-chlorophenyl)-5-morpholin-4-yl-4H-imidazol-2-one;1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one
CBNumber
CB71260929
Molecular Formula
C13H14ClN3O2
Formula Weight
279.72
MOL File
188116-07-6.mol
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1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one Property

Melting point:
264℃ (ethanol )
Boiling point:
421.8±55.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF:10.0(Max Conc. mg/mL);35.75(Max Conc. mM)
DMSO:17.5(Max Conc. mg/mL);62.56(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.79(Max Conc. mM)
Ethanol:1.13(Max Conc. mg/mL);4.02(Max Conc. mM)
form 
A crystalline solid
pka
4.39±0.20(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3361
Product name
Imepitoin
Purity
≥98% (HPLC)
Packaging
10MG
Price
$82.22
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3361
Product name
Imepitoin
Purity
≥98% (HPLC)
Packaging
50MG
Price
$386
Updated
2025/07/31
Cayman Chemical
Product number
16235
Product name
AWD 131-138
Purity
≥98%
Packaging
5mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
16235
Product name
AWD 131-138
Purity
≥98%
Packaging
10mg
Price
$198
Updated
2024/03/01
Cayman Chemical
Product number
16235
Product name
AWD 131-138
Purity
≥98%
Packaging
25mg
Price
$467
Updated
2024/03/01
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1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one Chemical Properties,Usage,Production

Uses

1-(4-Chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)-2H-imidazol-2-one is used in treating feline epilepsy.

Biological Activity

Imepitoin (AWD 131-138; ELB 138) is a g-aminobutyric acid A (GABAA) receptor partial positive allosteric modulator (PAM) th at targets the benzodiazepine (BZD)-binding site at the α/γ2-interface. Imepitoin enhances GABA current (% response/[GABA] alone in μM/receptor complex = 320/3/α1β2γ2, 310/25/α1β3γ2, 460/8/α2β2γ2, 590/12/α3β2γ2 and 290/3/α5β2γ2 using Xenopus oocytes expressing respective r at receptor complex) with ~2% the potency and 17-27% the efficacy of diazepam toward α1β2γ2. Imepitoin exhibits in vivo therapeutic efficacy in animal models of seizure and epilepsy.

in vivo

AWD 131-138 did not produce midazolam-like responding or alter response rates at cumulative doses up to 18.0 mg/kg i.m. (plasma levels over 2100 ng/ml). When AWD 131-138 (10-100 microg/kg/injection) was studied by substitution, responding declined to vehicle substitution levels within three sessions. At the dose of 100 microg/kg i.v. AWD 131-138, sufficient drug was self-administered during the first session (about 3.5 mg/kg) to produce plasma levels above 1000 ng/ml, yet responding over the next two sessions dropped to vehicle levels [2]. Prolonged oral administration with twice-daily dosing of ELB 138 with either 5 or 40 mg/kg over a 5-week period was not associated with loss of anticonvulsant efficacy in the PTZ dog model [3].

1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one Suppliers

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View Lastest Price from 1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one manufacturers

Career Henan Chemical Co
Product
1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one 188116-07-6
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

188116-07-6, 1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-oneRelated Search:

Imatinib Itraconazole Ipamorelin 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione IXABEPILONE

  • 1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one
  • Imepitoin
  • 1-(4-CHLOROPHENYL)-4-MORPHOLINO-1H-IMIDAZOL-2(5H)-ONE
  • 1-(4-Chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)-2H-imidazol-2-one
  • 2H-Imidazol-2-one,1-(4-chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)-
  • Imepitoin 1-(4-Chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)-2H-imidazol-2-one
  • AWD 131-138, >=98%
  • IMEPITOIN; AWD131-138
  • CS-1057
  • AWD 131-138(Imepitoin)
  • 3-(4-chlorophenyl)-5-morpholin-4-yl-4H-imidazol-2-one
  • AWD 131-13
  • ELB-138
  • 1-(4-chlorophenyl)-4-morpholino-1,5-dihydro-2H-imidazol-2-one
  • 1-(4-CHLOROPHENYL)-4-MORPHOLIN-4-YL-5H-IMIDAZOL-2-ONE/High quality/Best price/In stock
  • Inhibitor,Gamma-aminobutyric acid Receptor,Imepitoin,GABA Receptor,γ-Aminobutyric acid Receptor,inhibit
  • Imepitoin, 10 mM in DMSO
  • 188116-07-6
  • Inhibitors