ChemicalBook > CAS DataBase List > 8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine
8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine
- Product Name
- 8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine
- CAS No.
- 279215-43-9
- Chemical Name
- 8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine
- Synonyms
- NN414;tifenazoxide;NN414 >=98% (HPLC);NN 414 - Tifenazoxide;6-Chloro-3-[[1-methylcyclopropyl]amino]-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide;2H-Thieno[3,2-e]-1,2,4-thiadiazin-3-amine, 6-chloro-N-(1-methylcyclopropyl)-, 1,1-dioxide;8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine
- CBNumber
- CB71261289
- Molecular Formula
- C9H10ClN3O2S2
- Formula Weight
- 291.78
- MOL File
- 279215-43-9.mol
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8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine Property
- Melting point:
- 251-252 °C (decomp)(Solv: methanol (67-56-1); water (7732-18-5))
- Boiling point:
- 448.0±55.0 °C(Predicted)
- Density
- 1.88±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble15mg/mL, clear
- pka
- -6.81±0.20(Predicted)
- form
- powder
- color
- white to beige
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0553
- Product name
- NN414
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $156
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML0553
- Product name
- NN414
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $620
- Updated
- 2024/03/01
ChemScene
- Product number
- CS-0067041
- Product name
- Tifenazoxide
- Purity
- >99.0%
- Packaging
- 10mg
- Price
- $650
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0067041
- Product name
- Tifenazoxide
- Purity
- >99.0%
- Packaging
- 5mg
- Price
- $400
- Updated
- 2021/12/16
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8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine Chemical Properties,Usage,Production
Biological Activity
NN414 is a potent Kir6.2/SUR1 selective K-ATP channel opener. Activation of the pancreatic Kir6.2/SUR KATP channels inhibits insulin release to induce beta cell rest, reducing the workload of the beta cell which is thought may prove beneficial for patients with type 2 diabetes. A recent study found th at NN414 also triggered burst-like discharges in substantia nigra dopamine neurons. These K-ATP channel enabled burst-like discharges are associated with novelty-dependent exploratory behavior and may also have relevance to Parkinsonμs disease.
8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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8-chloro-N-(1-methylcyclopropyl)-2,2-dioxo-2$l^{6},9-dithia-3,5-diazab icyclo[4.3.0]nona-3,7,10-trien-4-amine Suppliers
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