1H-Benzimidazole-2-methanol,5-chloro-1-methyl-(9CI)
- Product Name
- 1H-Benzimidazole-2-methanol,5-chloro-1-methyl-(9CI)
- CAS No.
- 380177-22-0
- Chemical Name
- 1H-Benzimidazole-2-methanol,5-chloro-1-methyl-(9CI)
- Synonyms
- 1H-Benzimidazole-2-methanol, 5-chloro-1-methyl-;(5-chloro-1-methyl-1H-benzimidazol-2-yl)methanol;1H-Benzimidazole-2-methanol,5-chloro-1-methyl-(9CI);(5-chloro-1-Methyl-1H-benzo[d]iMidazol-2-yl)Methanol
- CBNumber
- CB71294784
- Molecular Formula
- C9H9ClN2O
- Formula Weight
- 196.63
- MOL File
- 380177-22-0.mol
1H-Benzimidazole-2-methanol,5-chloro-1-methyl-(9CI) Property
- Boiling point:
- 385.8±22.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 13.61±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C994513
- Product name
- (5-Chloro-1-methyl-1H-benzo[d]imidazol-2-yl)methanol
- Packaging
- 250mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- HCH0317725
- Product name
- (5-CHLORO-1-METHYL-1H-1,3-BENZODIAZOL-2-YL)METHANOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.74
- Updated
- 2021/12/16
- Product number
- CM125113
- Product name
- (5-chloro-1-methyl-1H-benzo[d]imidazol-2-yl)methanol
- Purity
- 97%
- Packaging
- 5g
- Price
- $916
- Updated
- 2021/12/16
- Product number
- CD11132639
- Product name
- (5-Chloro-1-methyl-1H-benzo[d]imidazol-2-yl)methanol
- Purity
- 97%
- Packaging
- 5g
- Price
- $972
- Updated
- 2021/12/16
- Product number
- 380177220
- Product name
- (5-Chloro-1-methyl-1H-benzo[d]imidazol-2-yl)methanol
- Packaging
- 5g
- Price
- $989.8
- Updated
- 2021/12/16
1H-Benzimidazole-2-methanol,5-chloro-1-methyl-(9CI) Chemical Properties,Usage,Production
Synthesis
6953-65-7
74-88-4
380177-22-0
The general procedure for the synthesis of 5-chloro-1-methyl-1H-benzo[d]imidazole-2-methanol from (6-chloro-1H-benzimidazol-2-yl)methanol and iodomethane was as follows: the N-methyl-2-methanol-5-chloro-benzimidazole 49 was prepared with reference to the method of Harisha et al. [28] (6-chloro-1H-benzimidazol-2-yl)methanol 28 (1.50 g , 8.20 mmol) and sodium hydroxide (0.33 g, 8.2 mmol) were dissolved in anhydrous acetone (30 mL) and stirred for 30 min. Subsequently, iodomethane (1.41 g, 8.20 mmol) was added and the reaction mixture continued to be stirred for 24 hours. Upon completion of the reaction, the mixture was concentrated to one-fourth of the original volume and poured into ice-cold water. The precipitated solid was collected and washed with 50% hydrochloric acid to neutralize the excess potassium carbonate. Next, the solids were washed sequentially with cold water (100 mL) and aqueous ethanol. Finally, the product was purified by column chromatography (eluent ratio 9:1 chloroform/ethanol) to afford the target compound 38 as bright orange crystals in 9% yield.
References
[1] Bulletin of the Korean Chemical Society, 2013, vol. 34, # 4, p. 1272 - 1274
[2] Molecules, 2015, vol. 20, # 8, p. 15206 - 15223
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 2, p. 933 - 936
1H-Benzimidazole-2-methanol,5-chloro-1-methyl-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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