4-CHLORO-3-(TRIFLUOROMETHOXY)BENZOIC ACID

Product Name: 4-CHLORO-3-(TRIFLUOROMETHOXY)BENZOIC ACID
CAS No.: 886500-50-1
Chemical Name: 4-CHLORO-3-(TRIFLUOROMETHOXY)BENZOIC ACID
Synonyms: 4-CHLORO-3-(TRIFLUOROMETHOXY)BENZOIC ACID;Benzoic acid, 4-chloro-3-(trifluoroMethoxy)-
CBNumber: CB7129805
Molecular Formula: C8H4ClF3O3
Formula Weight: 240.56
MOL File: Mol file

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4-CHLORO-3-(TRIFLUOROMETHOXY)BENZOIC ACID Property

Melting point:: 123-126℃
Boiling point:: 276.6±35.0℃ (760 Torr)
Density: 1.558±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:: 121.1±25.9℃
storage temp.: Sealed in dry,Room Temperature
pka: 3.59±0.10(Predicted)
Appearance: white solid
Water Solubility: Sparingly Soluble in water.

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Safety

HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Apolloscientific

Product number: PC302741
Product name: 4-Chloro-3-(trifluoromethoxy)benzoicacid
Purity: 99%
Packaging: 10g
Price: $290
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC105862
Product name: 4-chloro-3-(trifluoromethoxy)benzoic Acid
Packaging: 5G
Price: $230
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2621-7-55
Product name: 4-Chloro-3-(trifluoromethoxy)benzoic acid
Packaging: 10g
Price: $232
Updated: 2021/12/16

Matrix Scientific

Product number: 094569
Product name: 4-Chloro-3-(trifluoromethoxy)benzoic acid
Purity: 95+%
Packaging: 5g
Price: $260
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC105862
Product name: 4-chloro-3-(trifluoromethoxy)benzoic Acid
Packaging: 10g
Price: $370
Updated: 2021/12/16

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4-CHLORO-3-(TRIFLUOROMETHOXY)BENZOIC ACID Chemical Properties,Usage,Production

Uses

4-Chloro-3-(trifluoromethoxy)benzoic acid is used as pharmaceuticals intermediates.

Synthesis

1261444-00-1

886500-50-1

General procedure for the synthesis of 4-chloro-3-trifluoromethoxybenzoic acid from methyl 4-chloro-3-(trifluoromethoxy)benzoate: to a methanol (30 mL) solution containing methyl 4-chloro-3-(trifluoromethoxy)benzoate (3.1 g, 12.18 mmol) was slowly added sodium hydroxide (1.46 g, 36.50 mmol) in a water ( 10mL) solution. The reaction mixture was stirred continuously for 1.5 hours at room temperature. Upon completion of the reaction, the pH of the reaction mixture was adjusted with 36% hydrochloric acid solution to 4. Subsequently, the solution was extracted with ethyl acetate (3 x 100 mL), all organic layers were combined and dried with anhydrous sodium sulfate. After filtration to remove solid impurities, the mixture was concentrated under reduced pressure to afford the target product 4-chloro-3-(trifluoromethoxy)benzoic acid as a light yellow solid (2.10 g, 74% yield). The product was analyzed by LC/MS (ES, m/z) to confirm: [M + H]+ 241.0. 1H NMR (300 MHz, DMSO) data were as follows: δ 7.92-7.99 (m, 2H), 7.40-7.47 (m, 1H).

References

[1] Patent: WO2014/66795, 2014, A1. Location in patent: Paragraph 0175

4-CHLORO-3-(TRIFLUOROMETHOXY)BENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-3-(TRIFLUOROMETHOXY)BENZOIC ACID Suppliers

China 69 India 2 United Kingdom 5 United States 8 Global 84

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886500-50-1