clusterin

Source Background

Product Name: clusterin
Chemical Name: clusterin
Synonyms: Clu;Msgp-2;AI893575;D14Ucla3;clusterin;40 beta-chain;40 alpha-chain;Complement cytolysis inhibitor(CLI);Recombinant Mouse Clusterin/Clu Protein, His Tag;Recombinant Human Clusterin/CLU Protein, His Tag
CBNumber: CB71306674
Formula Weight: 0
MOL File: Mol file

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clusterin Property

storage temp.: -20°C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 154043
Product name: Clusterin
Packaging: 10ug
Price: $325
Updated: 2021/12/16

Usbiological

Product number: 154046
Product name: Clusterin
Packaging: 10ug
Price: $333
Updated: 2021/12/16

Usbiological

Product number: 154042
Product name: Clusterin
Packaging: 10ug
Price: $339
Updated: 2021/12/16

Usbiological

Product number: 154044
Product name: Clusterin
Packaging: 10ug
Price: $343
Updated: 2021/12/16

Usbiological

Product number: 154045
Product name: Clusterin
Packaging: 10ug
Price: $343
Updated: 2021/12/16

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clusterin Chemical Properties,Usage,Production

Source

Plasma

Background

Clusterin also named Apolipoprotein J (APO-J) is a 75-80 kD disulfide-linked heterodimeric protein containing about 30% of N-linked carbohydrate rich in sialic acid but truncated forms targeted to the nucleus have also been identified.
The precursor polypeptide chain is cleaved proteolytically to remove the 22-mer secretory signal peptide and subsequently between residues 227/228 to generate the a and b chains. These are assembled in anti-parallel to give a heterodimeric molecule in which the cysteine-rich centers are linked by five disulfide bridges and are flanked by two predicted coiled-coil a-helices and three predicted amphipathic a-helices.
Across a broad range of species clusterin shows a high degree of sequence homology ranging from 70% to 80%. It is nearly ubiquitously expressed in most mammalian tissues and can be found in plasma, milk, urine, cerebrospinal fluid and semen.
It is able to bind and form complexes with numerous partners such as immunoglobulins, lipids, heparin, bacteria, complement components, paraoxonase, beta amyloid, leptin and others. Clusterin has been ascribed a plethora of functions such as phagocyte recruitment, aggregation induction, complement attack prevention, apoptosis inhibition, membrane remodeling, lipid transport, hormone transport and/or scavenging, matrix metalloproteinase inhibition.
A genuine function of clusterin has not been defined. One tempting hypothesis says that clusterin is an extracellular chaperone protecting cells from stress induced insults caused by degraded and misfolded protein precipitates.
Clusterin is up- or down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others.

clusterin Preparation Products And Raw materials

Raw materials

Preparation Products

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clusterin Suppliers

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clusterinRelated Search:

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clusterin

Clu

D14Ucla3

AI893575

Recombinant Human Clusterin/CLU Protein, Fc & His Tag

Recombinant Human Clusterin/CLU Protein, His Tag

Recombinant Mouse Clusterin/Clu Protein, His Tag

40 beta-chain

Msgp-2

40 alpha-chain

Complement cytolysis inhibitor(CLI)

Testosterone-repressed prostate message 2(TRPM-2)