pyoluteorin Property

Melting point:

174-175 °C (decomp)

Boiling point:

436.9±45.0 °C(Predicted)

Density 

1.4931 (rough estimate)

refractive index 

1.6140 (estimate)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

solid

pka

6.97±0.35(Predicted)

color 

White to off-white

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

pyoluteorin Chemical Properties,Usage,Production

Uses

Pyoluteorin is a small chlorinated pyrrol produced by several species of Pseudomonas, first reported in 1958. Pyoluteorin exhibits a broad bioprofile, demonstrating antibiotic, antifungal and herbicidal activity. More recently, pyoluteorin has been investigated as bio-pesticide and has been shown to modulate the levels of metabolites in Pseudomonas.

Definition

ChEBI: Pyoluteorin is a member of the class of resorcinols that is resorcinol in which the hydrogen at position 2 is replaced by a 4,5-dichloro-1H-pyrrole-2-carbonyl group. It is a natural product found in Pseudomonas fluorescens which exhibits antibacterial properties and is a strong inducer of caspase-3-dependent apoptosis. It has a role as a bacterial metabolite, an apoptosis inducer, an antifungal agent, a marine metabolite and an antibacterial agent. It is a member of resorcinols, a member of pyrroles, an organochlorine compound, a diol, a beta-hydroxy ketone, a polyketide, an aromatic ketone and an organochlorine pesticide.

Biological Activity

pyoluteorin is a secondary metabolite produced by the biological control organism pseudomonas fluorescens pf-5, a rhizosphere bacterium. pyoluteorin shows no toxicity to seed- and root-rotting plant pathogens. pyoluteorin production is influenced by positive autoregulation. addition of pyoluteorin to liquid cultures of pf-5 enhanced pyoluteorin production.pyoluteorin functions as a signal molecule negatively regulating additional secondary metabolites produced by pseudomonas [1]. the pyoluteorin contributes to the biological control of soilborne plant diseases by some strains of pseudomonas fluorescens, including pf-5. pyoluteorin induces its own productionand represses the other’s production [2]. depending on the plant, pyoluteorin production plays an important role in the suppression of damping-off by strain cha0 without being a major mechanism in disease suppression [3].

Safety Profile

A poison by ingestion and intraperitoneal routes. A flammable liquid. When heated to decomposition it emits toxic vapors of NOx and Cl-.

References

[1] brodhagen m, henkels m d, loper j e. positive autoregulation and signaling properties of pyoluteorin, an antibiotic produced by the biological control organism pseudomonas fluorescens pf-5[j]. applied and environmental microbiology, 2004, 70(3): 1758-1766.
[2] kidarsa t a, goebel n c, zabriskie t m, et al. phloroglucinol mediates cross‐talk between the pyoluteorin and 2, 4‐diacetylphloroglucinol biosynthetic pathways in pseudomonas fluorescens pf‐5[j]. molecular microbiology, 2011, 81(2): 395-414.
[3] maurhofer m, keel c, haas d, et al. pyoluteorin production bypseudomonas fluorescens strain cha0 is involved in the suppression ofpythium damping-off of cress but not of cucumber[j]. european journal of plant pathology, 1994, 100(3): 221-232.