chlorothricin

Product Name: chlorothricin
CAS No.: 34707-92-1
Chemical Name: chlorothricin
Synonyms: K-818A;18H-16a,19-Metheno-16aH-benzo[e]naphtho[2,1-m][1,4]dioxacyclopentadecin-14-carboxylic acid, 4-[[4-O-[3-O-(3-chloro-6-methoxy-2-methylbenzoyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1,2,3,4,4a,6a,7,8,9,10,12a,15,16,21,21a,21b-hexadecahydro-22-hydroxy-15,21a-...
CBNumber: CB71339265
Molecular Formula: C50H63ClO16
Formula Weight: 955.48
MOL File: 34707-92-1.mol

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chlorothricin Property

Melting point:: 206-207°
Boiling point:: 1050.8±65.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in ethanol;Soluble in methanol;Soluble in DMSO;Soluble in dimethyl formamide
form: solid
pka: pK: 5.01, 7.91(at 25℃)
color: white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15501
Product name: Chlorothricin
Purity: ≥99%
Packaging: 1mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 15501
Product name: Chlorothricin
Purity: ≥99%
Packaging: 5mg
Price: $606
Updated: 2024/03/01

TRC

Product number: C428273
Product name: Chlorothricin
Packaging: 2.5mg
Price: $285
Updated: 2021/12/16

TRC

Product number: C428273
Product name: Chlorothricin
Packaging: 1mg
Price: $145
Updated: 2021/12/16

ApexBio Technology

Product number: C4515
Product name: Chlorothricin
Packaging: 5mg
Price: $624
Updated: 2021/12/16

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chlorothricin Chemical Properties,Usage,Production

Uses

Chlorothricin is a spirotetronic acid antibiotic inhibitor of pyruvate carboxylase.

Uses

The tetronic acid, chlorothricin, is an unusual macrocyclic antibiotic from a Streptomyces sp., related to kijanimicin, saccharocarcins, tetrocarcins and versipelostatin. Chlorothricin inhibits cholesterol biosynthesis from mevalonate, and inhibits pyruvate carboxylases purified from rat liver, chicken liver and Azotobacter vinelandii.

Biological Activity

chlorothricin is a macrolide-type antibiotic.macrolides, a class of natural products belonging to the polyketide class of natural products, consist of a large macrocyclic lactone ring. the lactone rings are oftem 14-, 15-, or 16-membered. some macrolides have been reported to have antibiotic or antifungal activity and are widely used as pharmaceutical drugs.

in vitro

in a previous study, chlorothricin was found to inhibit the reaction catalyzed by pyruvate carboxylase from bacillus stearothermophilus. moreover, with steady-state kinetic measurements, inhibition of the overall reaction was found to be competitive with the allosteric activator of this enzyme, coasac, and non-competitive with respect to both substrates of mgatp and pyruvate. these findings strongly indicated that the site 1conformation of pyruvate carboxylase responsible for the regulation of the overall enzyme activity could be influenced by chlorothricin and coasac in an antagonistic manner [1].

IC 50

173, 500, 260, and 120 μm for pyruvate carboxylases from bacillus, azotobacter, rat, and chicken, respectively.

References

[1] schindler pw, zhner h. mode of action of the macrolide-type antibiotic, chlorothricin. kinetic study of the inhibition of pyruvate carboxylase from bacillus stearothermophilus. eur j biochem. 1973 nov 15;39(2):591-600.

chlorothricin Preparation Products And Raw materials

Raw materials

Preparation Products

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chlorothricin Suppliers

China 12 Germany 1 India 1 South Korea 1 United Kingdom 1 United States 4 Global 20

Lynnchem

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Shanghai Hao Zhun Biological Technology Co., Ltd.

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34707-92-1, chlorothricinRelated Search:

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K-818A

18H-16a,19-Metheno-16aH-benzo[e]naphtho[2,1-m][1,4]dioxacyclopentadecin-14-carboxylic acid, 4-[[4-O-[3-O-(3-chloro-6-methoxy-2-methylbenzoyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1,2,3,4,4a,6a,7,8,9,10,12a,15,16,21,21a,21b-hexadecahydro-22-hydroxy-15,21a-...

34707-92-1

C50H63ClO16