Norfenfluramine

Product Name: Norfenfluramine
CAS No.: 1886-26-6
Chemical Name: Norfenfluramine
Synonyms: Norfenfluramine (racemate);α-Methyl-m-(trifluoromethyl)phenethylamine;1-[3-(Trifluoromethyl)phenyl]-2-propanamine;1-[3-(Trifluoromethyl)phenyl]-2-aminopropane;Benzeneethanamine, α-methyl-3-(trifluoromethyl)-;[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amine;5-HTT,inhibit,antiepileptic,Norfenfluramine,Fenfluramine,transporter,Serotonin Transporter,5-HT,SLC6A4,SERT,Inhibitor
CBNumber: CB71341525
Molecular Formula: C10H12F3N
Formula Weight: 203.2
MOL File: 1886-26-6.mol

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Norfenfluramine Property

Boiling point:: 96 °C(Press: 17 Torr)
Density: 1.152±0.06 g/cm3(Predicted)
pka: 9.77±0.10(Predicted)

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Safety

Toxicity: LD50 intraperitoneal in mouse: 51mg/kg

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D458383
Product name: DesethylFenfluramine
Packaging: 100mg
Price: $220
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0006291
Product name: (+/-)-NORFENFLURAMINE
Purity: 95.00%
Packaging: 5MG
Price: $499.82
Updated: 2021/12/16

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Norfenfluramine Chemical Properties,Usage,Production

Uses

Norfenfluramine ((±)-Norfenfluramine) is a major and brain-penetrant metabolite of Fenfluramine. Norfenfluramine can interact with 5-HT transporters to release 5-HT from neurons. Norfenfluramine displays antiepileptic effects in vivo[1][2].

Definition

ChEBI: 1-[3-(trifluoromethyl)phenyl]-2-propanamine is a member of amphetamines.

References

[1] Rothman RB, et, al. (+)-Fenfluramine and its major metabolite, (+)-norfenfluramine, are potent substrates for norepinephrine transporters. J Pharmacol Exp Ther. 2003 Jun;305(3):1191-9. DOI:10.1124/jpet.103.049684
[2] Li J, et, al. Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome. Neurochem Res. 2021 Sep;46(9):2249-2261. DOI:10.1007/s11064-021-03358-2

Norfenfluramine Preparation Products And Raw materials

Raw materials

Preparation Products

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Norfenfluramine Suppliers

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1886-26-6, NorfenfluramineRelated Search:

(S)-1-(3-TRIFLUOROMETHYLPHENYL)-2-AMINOPROPANE RARECHEM AL CF 0912 (1R,2R)-(+)-N,N'-DIMETHYL-1,2-BIS[3-(TRIFLUOROMETHYL)PHENYL!-1,2-ETHANE DIAMINE, 99 FMOC-L-3-Trifluoromethylphe 3,5-BIS(TRIFLUOROMETHYL)-DL-PHENYLALANINE R(-)-FENFLURAMINE HYDROCHLORIDE FENFLURAMINE HYDROCHLORIDE 3-TRIFLUOROMETHYL-L-PHENYLALANINE 3-(TRIFLUOROMETHYL)-DL-PHENYLALANINE (R)-1-(3-TRIFLUOROMETHYLPHENYL)-2-AMINOPROPANE (1S,2S)-(-)-N,N'-DIMETHYL-1,2-BIS[3-(TRIFLUOROMETHYL)PHENYL!-1,2-ETHANE DIAMINE, 99 BENFLUOREX HYDROCHLORIDE N-ALPHA-CARBOBENZOXY-L-(3-TRIFLUOROPHENYL)ALANINE BOC-L-3-Trifluoromethylphe (S)-2-AMINO-3-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID (+)-FENFLURAMINE HYDROCHLORIDE

1-[3-(Trifluoromethyl)phenyl]-2-aminopropane

α-Methyl-m-(trifluoromethyl)phenethylamine

[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amine

Norfenfluramine (racemate)

5-HTT,inhibit,antiepileptic,Norfenfluramine,Fenfluramine,transporter,Serotonin Transporter,5-HT,SLC6A4,SERT,Inhibitor

Benzeneethanamine, α-methyl-3-(trifluoromethyl)-

1-[3-(Trifluoromethyl)phenyl]-2-propanamine

1886-26-6