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mebikar

Product Name
mebikar
CAS No.
10095-06-4
Chemical Name
mebikar
Synonyms
mebikar;Mebicar;Mebican;Temgicoluril;Imidazo[4,5-d]im;Tetramethylglycoluril;Mebicarum/TETRAMETHYLTETRAAZABICYCLOOCTANDION;4,5-(1,3-Dimethylureylene)-1,3-dimethylimidazolidine-2-one;2,4,6,8-Tetramethyl-2,4,6,8-tetraazabicyclo[3.3.0]-3,7-oxandione;1,3,4,6-Tetramethyl-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione
CBNumber
CB71344551
Molecular Formula
C8H14N4O2
Formula Weight
198.22
MOL File
10095-06-4.mol
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mebikar Property

Melting point:
226 - 229?C
Boiling point:
362.2±42.0 °C(Predicted)
Density 
1.237±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator, under inert atmosphere
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
-0.49±0.20(Predicted)
color 
White to Off-White
InChI
InChI=1S/C8H14N4O2/c1-9-5-6(11(3)7(9)13)12(4)8(14)10(5)2/h5-6H,1-4H3
InChIKey
XIUUSFJTJXFNGH-UHFFFAOYSA-N
SMILES
CN1C(N(C2N(C(N(C21)C)=O)C)C)=O
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Safety

HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
T889843
Product name
Tetrahydro-1,3,4,6-tetramethylimidazo(4,5-d)imidazole-2,5(1H,3H)-dione
Packaging
200mg
Price
$220
Updated
2021/12/16
Matrix Scientific
Product number
064483
Product name
1,3,4,6-Tetramethyltetrahydroimidazo[4,5-d]-imidazole-2,5(1H,3H)-dione
Packaging
500mg
Price
$315
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0015373
Product name
MEBIKAR
Purity
95.00%
Packaging
0.5G
Price
$396
Updated
2021/12/16
AK Scientific
Product number
7296AC
Product name
1,3,4,6-Tetramethyltetrahydroimidazo[4,5-d]-imidazole-2,5(1H,3H)-dione
Packaging
500mg
Price
$475
Updated
2021/12/16
Crysdot
Product number
CD11367733
Product name
1,3,4,6-Tetramethyltetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dione
Purity
95+%
Packaging
5g
Price
$904
Updated
2021/12/16
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mebikar Chemical Properties,Usage,Production

Uses

Temgicoluril (Tetramethylglycoluril) is an orally active antianxiety and antidepressant. Temgicoluril acts on GABA receptors to enhance GABA neurotransmission[1][2].

Definition

ChEBI: Mebicar is an imidazolidinone.

in vivo

Temgicoluril (10 mg/kg; Oral gavage; 3 weeks) has a preventive effect on neurobehavioral and immunological disruptions caused by intermittent unpredictable stress in mice[2].

Animal Model:Intermittent unpredictable stress (IUS) treated seven week-old Balb/cByJ mice[2]
Dosage:10 mg/kg
Administration:Oral gavage (i.g.); 3 weeks
Result:Recovered rapidly from anxiety-like behavior induced by the multiplexed stress compared with untreated mice.
Did not prevent the decrease of brain-derived neurotropic factor by IUS exposure.
Prevented elevation of serum corticosterone and secretion of proinflammatory cytokines from splenocytes due to IUS exposure.

References

[1] Val'dman AV, Zaikonnikova IV, Kozlovskaia MM, Zimakova IE. Izuchenie osobennoste? spektra psikhotropnogo de?stviia mebikara [Characteristics of the psychotropic spectrum of action of mebicar]. Biull Eksp Biol Med. 1980 May;89(5):568-70. Russian. PMID:6104993
[2] Kim CY, et al. Preventive Effect of Mebicar and Ginsenoside Rg1 on Neurobehavioral and Immunological Disruptions Caused by Intermittent Unpredictable Stress in Mice. Neuroimmunomodulation. 2018;25(1):49-58. DOI:10.1159/000489634

mebikar Preparation Products And Raw materials

Raw materials

Preparation Products

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mebikar Suppliers

China 40 India 1 Russia 1 South Korea 1 United States 6 Global 49
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aceschem Inc.
Tel
+1-817863-6948 +1-（817）863-6948
Email
sales@aceschem.com
Country
United States
ProdList
19632
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
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View Lastest Price from mebikar manufacturers

Hebei Dangtong Import and export Co LTD
Product
mebikar 10095-06-4
Price
US $72.00-68.00/Grams
Min. Order
10Grams
Purity
99.99%
Supply Ability
100Tons
Release date
2023-03-17
Shaanxi Dideu New Materials Co. Ltd
Product
mebikar 10095-06-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
95.0%
Supply Ability
10000KGS
Release date
2024-11-19

10095-06-4, mebikarRelated Search:

Tetramethylol acetylenediurea HEXAHYDRO-2,6-BIS(2,2,6,6-TETRAMETHYL-4-PIPERIDINYL)-1H,4H,5H,8H-2,3A,4A,6,7A,8A-HEXAAZACYCLOPENTA[DEF]FLUORENE-4,8-DIONE 1,3,4,6-Tetrakis(methoxymethyl)glycoluril CUCURBITURIL 1,3,4,6-TETRAKIS(BUTOXYMETHYL)GLYCOLURIL, TECH. N,N',N'',N'''-Tetraacetylglycoluril mebikar

  • mebikar
  • 2,4,6,8-Tetramethyl-2,4,6,8-tetraazabicyclo[3.3.0]-3,7-oxandione
  • 3a,4,6,6a-Tetrahydro-1,3,4,6-tetramethylimidazo[4,5-d]imidazole-2,5(1H,3H)-dione
  • 4,5-(1,3-Dimethylureylene)-1,3-dimethylimidazolidine-2-one
  • Mebicar
  • 1,3,4,6-tetramethyl-3a,6a-dihydroimidazo[4,5-d]imidazole-2,5-dione
  • 1,3,4,6-tetramethyl-3a,6a-dihydroimidazo[4,5-d]imidazole-2,5-quinone
  • 1,3,4,6-Tetramethyl-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione
  • 2,4,6,8-Tetraazabicyclo[3.3.0]octane-3,7-dione, 2,4,6,8-tetramethyl-
  • 2,4,6,8-Tetramethyl-2,4,6,8-tetraazobicyclo(3.3.0)octane-3,7-dione
  • 2,4,6,8-Tetramethyl-2,4,6,8-tetraazobizykl(3,3,0)oktandion-3,7 [German]
  • Imidazo[4,5-d]im
  • Tetrahydro-1,3,4,6-tetramethylimidazo(4,5-d)imidazole-2,5(1H,3H)-dione
  • 2,4,6,8-Тetramethyl-2,4,6,8,tetraazabycyclo[3.3.0] octane- 3,7-dione, Mebicar
  • Imidazo[4,5-d]imidazole-2,5(1H,3H)-dione, tetrahydro-1,3,4,6-tetramethyl-
  • Temgicoluril
  • Tetramethylglycoluril
  • Mebicarum/TETRAMETHYLTETRAAZABICYCLOOCTANDION
  • Mebican
  • inhibit,Inhibitor,γ-Aminobutyric acid Receptor,Mebicar,Temgicoluril,Gamma-aminobutyric acid Receptor,GABA Receptor
  • Imidazo[4,5-d]imidazole-2,5(1H,3H)-dione,tetrahydro-1,3,4,6-tetramet
  • 10095-06-4