BI-2865

Product Name: BI-2865
CAS No.: 2937327-93-8
Chemical Name: BI-2865
Synonyms: BI-2865
CBNumber: CB713546660
Molecular Formula: C23H27N7O2S
Formula Weight: 465.57
MOL File: 2937327-93-8.mol

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BI-2865 Property

Boiling point:: 708.7±70.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka: 9.35±0.40(Predicted)
form: Solid
color: Light yellow to brown

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Hazard and Precautionary Statements (GHS)

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BI-2865 Chemical Properties,Usage,Production

Description

BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 blocked nucleotide exchange to prevent the activation of wild-type KRAS and a broad range of KRAS mutants, including G12A/C/D/F/V/S, G13C/D, V14I, L19F, Q22K, D33E, Q61H, K117N and A146V/T. Inhibition of downstream signaling and proliferation was restricted to cancer cells harboring mutant KRAS, and drug treatment suppressed KRAS mutant tumor growth in mice without having a detrimental effect on animal weight.

Biological Activity

BI-2865 is a non-covalent pan-KRAS inhibitor that binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with Kd values of 6.9 nM, 4.5 nM, 32 nM, 26 nM, and 4.3 nM, respectively. It can be used in studies related to KRAS mutant tumors.

in vitro

BI-2865 is a derivative with a prolinol substituent and a pyrimidine linker. BI-2865 has direct ionic interaction with E62 and a water-mediated hydrogen bond network with the side chain of R68 and the main chain carbonyl of Q61. BI-2865 (5 days) inhibits the proliferation of G12C, G12D, or G12V mutant KRAS expressing BaF3 cells in the presence of IL-13, with a mean IC50 of roughly 140?nM.

BI-2865 Preparation Products And Raw materials

Raw materials

Preparation Products

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BI-2865 Suppliers

China 27 United States 1 Global 28

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View Lastest Price from BI-2865 manufacturers

Hubei Chuchang Biotech Co., Ltd.

Product: BI-2865 2937327-93-8
Price: US $0.00-0.00/mg
Min. Order: 5mg
Purity: 98%+ HPLC HNMR
Supply Ability: 20g
Release date: 2024-03-29

2937327-93-8, BI-2865Related Search:

BI-2865

2937327-93-8