BI-2865
- Product Name
- BI-2865
- CAS No.
- 2937327-93-8
- Chemical Name
- BI-2865
- Synonyms
- BI-2865
- CBNumber
- CB713546660
- Molecular Formula
- C23H27N7O2S
- Formula Weight
- 465.57
- MOL File
- 2937327-93-8.mol
BI-2865 Property
- Boiling point:
- 708.7±70.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
- pka
- 9.35±0.40(Predicted)
- form
- Solid
- color
- Light yellow to brown
BI-2865 Chemical Properties,Usage,Production
Description
BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 blocked nucleotide exchange to prevent the activation of wild-type KRAS and a broad range of KRAS mutants, including G12A/C/D/F/V/S, G13C/D, V14I, L19F, Q22K, D33E, Q61H, K117N and A146V/T. Inhibition of downstream signaling and proliferation was restricted to cancer cells harboring mutant KRAS, and drug treatment suppressed KRAS mutant tumor growth in mice without having a detrimental effect on animal weight.
Biological Activity
BI-2865 is a non-covalent pan-KRAS inhibitor that binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with Kd values of 6.9 nM, 4.5 nM, 32 nM, 26 nM, and 4.3 nM, respectively. It can be used in studies related to KRAS mutant tumors.
in vitro
BI-2865 is a derivative with a prolinol substituent and a pyrimidine linker. BI-2865 has direct ionic interaction with E62 and a water-mediated hydrogen bond network with the side chain of R68 and the main chain carbonyl of Q61. BI-2865 (5 days) inhibits the proliferation of G12C, G12D, or G12V mutant KRAS expressing BaF3 cells in the presence of IL-13, with a mean IC50 of roughly 140?nM.
BI-2865 Preparation Products And Raw materials
Raw materials
Preparation Products
BI-2865 Suppliers
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View Lastest Price from BI-2865 manufacturers
- Product
- BI-2865 2937327-93-8
- Price
- US $0.00-0.00/mg
- Min. Order
- 5mg
- Purity
- 98%+ HPLC HNMR
- Supply Ability
- 20g
- Release date
- 2024-03-29