2-Nitro-4-fluorophenol

Product Name: 2-Nitro-4-fluorophenol
CAS No.: 394-33-2
Chemical Name: 2-Nitro-4-fluorophenol
Synonyms: 4-FLUORO-2-NITROPHENOL;2-NITRO-4-FLUOROPHENOL;Phenol, 4-fluoro-2-nitro-;4-Fluoro-2-nitrophenol>4-Fluoro-2-nitrophenol99%;4-Fluoro-2-nitrophenol 99%;4-fluoro-2-nitrobenzophenol;4-FLUORO-2-NITROPHENOL, 98+%;5-Fluoro-2-hydroxynitrobenzene;2-Nitro-4-fluorophenol ISO 9001：2015 REACH
CBNumber: CB7136771
Molecular Formula: C6H4FNO3
Formula Weight: 157.1
MOL File: 394-33-2.mol

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2-Nitro-4-fluorophenol Property

Melting point:: 75-77 °C (lit.)
Boiling point:: 234.1±20.0 °C(Predicted)
Density: 1.4306 (estimate)
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
pka: 6.76±0.14(Predicted)
color: Orange to Green to Amber
BRN: 1950412
InChI: InChI=1S/C6H4FNO3/c7-4-1-2-6(9)5(3-4)8(10)11/h1-3,9H
InChIKey: ZHRLVDHMIJDWSS-UHFFFAOYSA-N
SMILES: C1(O)=CC=C(F)C=C1[N+]([O-])=O
CAS DataBase Reference: 394-33-2(CAS DataBase Reference)
NIST Chemistry Reference: 4-Fluoro-2-nitrophenol(394-33-2)
EPA Substance Registry System: 4-Fluoro-2-nitrophenol (394-33-2)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29089000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 345059
Product name: 4-Fluoro-2-nitrophenol
Purity: 99%
Packaging: 5g
Price: $35
Updated: 2023/06/20

Sigma-Aldrich

Product number: 345059
Product name: 4-Fluoro-2-nitrophenol
Purity: 99%
Packaging: 25g
Price: $70
Updated: 2023/06/20

TCI Chemical

Product number: F0367
Product name: 4-Fluoro-2-nitrophenol
Purity: >98.0%(GC)
Packaging: 5g
Price: $34
Updated: 2025/07/31

TCI Chemical

Product number: F0367
Product name: 4-Fluoro-2-nitrophenol
Purity: >98.0%(GC)
Packaging: 25g
Price: $133
Updated: 2025/07/31

TRC

Product number: F597635
Product name: 4-Fluoro-2-nitrophenol
Packaging: 1g
Price: $55
Updated: 2021/12/16

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2-Nitro-4-fluorophenol Chemical Properties,Usage,Production

Chemical Properties

yellow crystalline powder

Uses

4-Fluoro-2-nitrophenol may be used in the preparation of 5-fluoro-2-methoxyanilineand 5-fluoro-2-hydroxyaniline.

General Description

4-Fluoro-2-nitrophenol is formed during iron(III) nitrate nonahydrate activated by tungstophosphoric acid cesium salt catalyzed nitration of 4-fluorophenol.

Synthesis

371-41-5

394-33-2

The general procedure for the synthesis of 2-nitro-4-fluorophenol from 4-fluorophenol was as follows: silica-loaded Al(NO3)3-9H2O (1 mmol) was added to a solution of 4-fluorophenol (1 mmol) in acetone (5 mL) and the reaction mixture was stirred at room temperature. The reaction process was monitored by TLC. Upon completion of the reaction, the reaction mixture was filtered and the silica residue was washed with ethyl acetate (25 mL). The filtrate and washings were combined and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (100-200 mesh) to give 2-nitro-4-fluorophenol (95%) and 4-nitro-4-fluorophenol (3%).

References

[1] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1983, p. 75 - 82
[2] Synthetic Communications, 1997, vol. 27, # 19, p. 3301 - 3311
[3] Synlett, 2003, # 2, p. 191 - 194
[4] Synthetic Communications, 2005, vol. 35, # 2, p. 263 - 270
[5] Synthetic Communications, 1998, vol. 28, # 15, p. 2773 - 2781

2-Nitro-4-fluorophenol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Nitro-4-fluorophenol Suppliers

Americas 1 Belgium 2 China 148 Czech Republic 2 Europe 3 France 1 Germany 3 India 11 Italy 1 Japan 4 Slovakia 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 17 United States 28 Global 226

Shanghai Harvest Chemical Industrial Co., Ltd.

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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

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View Lastest Price from 2-Nitro-4-fluorophenol manufacturers

Honest Joy Holdings Limited

Product: 4-Fluoro-2-nitrophenol 394-33-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.2%
Supply Ability: 100 tons
Release date: 2022-02-21

Career Henan Chemical Co

Product: 2-Nitro-4-fluorophenol 394-33-2
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10000KGS
Release date: 2020-01-10

394-33-2, 2-Nitro-4-fluorophenolRelated Search:

2,6-DINITRO-4-FLUOROPHENOL 2-Nitro-4-fluorophenol 4-Fluoro-2-nitroanisole 5-FLUORO-2-NITROPHENOL,2-NITRO-5-FLUOROPHENOL,6-Nitro-3-fluorophenol,2-Nitro-5-Fluorophenol 2-Fluoro-6-nitrophenol 4-Fluoro-3-nitrophenol 2-nitro-3-fluorophenol Nitrophenol 4-Fluorophenol 2-Nitrophenol 3-(4-FLUORO-2-NITROPHENOXY)-N-METHYL-2-THIOPHENECARBOXAMIDE 3-(4-FLUORO-2-NITROPHENOXY)-N-[3-(TRIFLUOROMETHYL)PHENYL]-2-THIOPHENECARBOXAMIDE 4-fluoro-2-nitrophenyl 4-methylbenzenecarboxylate N-(2,5-DIMETHOXYPHENYL)-3-(4-FLUORO-2-NITROPHENOXY)-2-THIOPHENECARBOXAMIDE 3-(4-FLUORO-2-NITROPHENOXY)-N,N-DIMETHYL-2-THIOPHENECARBOXAMIDE N-(4-CHLOROPHENYL)-3-(4-FLUORO-2-NITROPHENOXY)-2-THIOPHENECARBOXAMIDE N-ALLYL-3-(4-FLUORO-2-NITROPHENOXY)-2-THIOPHENECARBOXAMIDE 4-FLUORO-2-NITROPHENYL 4-CHLOROBENZENECARBOXYLATE

4-FLUORO-2-NITROPHENOL

4-Fluoro-2-nitrophenol 99%

4-Fluoro-2-nitrophenol99%

4-fluoro-2-nitrobenzophenol

4-FLUORO-2-NITROPHENOL, 98+%

5-Fluoro-2-hydroxynitrobenzene

Phenol, 4-fluoro-2-nitro-

2-NITRO-4-FLUOROPHENOL

4-Fluoro-2-nitrophenol&gt

2-Nitro-4-fluorophenol ISO 9001：2015 REACH

394-33-2

C6H4NO3

C6H4NO3F

Organic Building Blocks

Oxygen Compounds

Phenols

Building Blocks

Phenol&Thiophenol&Mercaptan

Organic Building Blocks

Oxygen Compounds

Phenols

Aromatic Phenols