1,3,5-Tri-O-benzoyl-D-ribofuranose

Product Name: 1,3,5-Tri-O-benzoyl-D-ribofuranose
CAS No.: 22224-41-5
Chemical Name: 1,3,5-Tri-O-benzoyl-D-ribofuranose
Synonyms: Clofarabine Impurity 5;1,3,5-Bz-D-ribofuranose;1,3,5-tri-benzoyl-α-D-ribose;1,3,5-tri-O-Benzoyl-alpha-D-Ri;Clofarabine intermediate (III);1,3,5-TRIBENZOYL-A-D-RIBOFURANOSE;1,3,5-Tribenzoyl-α-D-ribofuranose;1,3,5-Tri-O-benzoyl-D-ribofuranose;1,3,5-Tribenzoate-α-D-Ribofuranose;1,3,5-tribenzoate-a-D-Ribofuranose
CBNumber: CB7138063
Molecular Formula: C26H22O8
Formula Weight: 462.45
MOL File: 22224-41-5.mol

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1,3,5-Tri-O-benzoyl-D-ribofuranose Property

Melting point:: 125-129 °C(lit.)
Boiling point:: 629.6±55.0 °C(Predicted)
Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Powder
pka: 12.35±0.70(Predicted)
color: Pale brown
optical activity: [α]20/D +85.0°, c = 1 in chloroform
Water Solubility: Insoluble in water, easily soluble in chloroform.
λmax: 273nm(MeOH)(lit.)
BRN: 98446
InChIKey: HUHVPBKTTFVAQF-QFBXJQHPSA-N
SMILES: O(C(=O)C1=CC=CC=C1)C1O[C@H](COC(=O)C2=CC=CC=C2)[C@@H](OC(=O)C2=CC=CC=C2)[C@H]1O |&1:11,22,32,r|
CAS DataBase Reference: 22224-41-5(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29400090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 389080
Product name: α-D-Ribofuranose 1,3,5-tribenzoate
Purity: 97%
Packaging: 5g
Price: $93.3
Updated: 2023/06/20

TCI Chemical

Product number: T2641
Product name: 1,3,5-Tri-O-benzoyl-α-D-ribofuranose
Purity: >97.0%(HPLC)
Packaging: 5g
Price: $96
Updated: 2025/07/31

TCI Chemical

Product number: T2641
Product name: 1,3,5-Tri-O-benzoyl-α-D-ribofuranose
Purity: >97.0%(HPLC)
Packaging: 25g
Price: $329
Updated: 2025/07/31

TRC

Product number: B209535
Product name: 1,3,5-Tri-O-benzoyl-α-D-ribofuranose
Packaging: 10g
Price: $70
Updated: 2021/12/16

Usbiological

Product number: 294691
Product name: 1,3,5-Tri-O-benzoyl-a-D-ribofuranose
Packaging: 1g
Price: $300
Updated: 2021/12/16

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1,3,5-Tri-O-benzoyl-D-ribofuranose Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

It is employed as a starting material for nucleosides and is an intermediate fir cloforabine.

Uses

Starting material for nucleosides.

Synthesis

6974-32-9

22224-41-5

Synthesis of compound vi: Compound v (2.57 mmol) was dissolved in 26 mL of anhydrous dichloromethane, and the reaction lasted for 2.5 h under the condition of ice-water bath with slow passage of dry HCl gas. After completion of the reaction, the reaction solution was washed with 19.5 mL of ice water and the organic layer was separated. The organic layer was washed sequentially with saturated sodium bicarbonate solution until the aqueous layer was weakly basic, and then washed with ice water until the aqueous layer was neutral. The organic layer was dried with anhydrous sodium sulfate for more than 4 hours and subsequently concentrated under reduced pressure to give a light yellow syrupy product. The syrup was recrystallized using a solvent mixture of hexane and dichloromethane to give the white solid compound vi in 65.1% yield.1H NMR (CDCl3) δ ppm: 7.36-8.14 (m, 15H, OBz), 6.68 (d, J = 4.4 Hz, 1H, H-1), 5.59 (dd, 1H, H-3), 4.64-4.80 ( m, 4H, H-2, H-4 and H-5). Melting point: 139-140°C.

References

[1] Patent: EP2177527, 2010, A1. Location in patent: Page/Page column 11
[2] Journal of Organic Chemistry, 1985, vol. 50, # 14, p. 2597 - 2598

1,3,5-Tri-O-benzoyl-D-ribofuranose Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3,5-Tri-O-benzoyl-D-ribofuranose Suppliers

China 257 Europe 1 Germany 2 India 10 Japan 1 Switzerland 2 United Kingdom 7 United States 32 Global 312

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View Lastest Price from 1,3,5-Tri-O-benzoyl-D-ribofuranose manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 1,3,5-Tri-O-benzoyl-D-ribofuranose 22224-41-5
Price: US $0.00-0.00/g
Min. Order: 100g
Purity: 97%min
Supply Ability: 10000g
Release date: 2021-08-28

Henan Aochuang Chemical Co.,Ltd.

Product: 1,3,5-Tri-O-benzoyl-D-ribofuranose 22224-41-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1,3,5-Tri-O-benzoyl-D-ribofuranose 22224-41-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

22224-41-5, 1,3,5-Tri-O-benzoyl-D-ribofuranoseRelated Search:

Denatonium Benzoate Anhydrous Dibenzofuran Emamectin benzoate Benzoyl peroxide Sodium benzoate Benzoyl chloride Benzyl benzoate Benzofuran Sofosbuvir alpha-D-erythro-Pentofuranous-2-ulose 1,3,5-tribenzoate Sofosbuvir Impurity26 SofosBuvir Impurity 2 1-((2S,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione sofosBuvir Impurity 33 sofosBuvir impurity 49 SofosBuvir Impurity 55 Sofosbuvir Impurity 84 PSI 7411

1,3,5-TRI-O-BENZOYL-ALPHA-D-RIBOFURANOSE

1,3,5-TRI-O-BENZOYL-ALPHA-D-RIBOFURANOSIDE

1,3,5-Tri-O-benzoyl-D-ribofuranose

1,3,5-TRIBENZOATE-ALPHA-D-RIBOFURANOSE

[5-(benzoyloxy)-2-(benzoyloxymethyl)-4-hydroxyoxolan-3-yl] benzoate

ALPHA-D-RIBOFURANOSE 1,3,5-TRIBENZOATE

α-D-Ribofuranose, 1,3,5-tribenzoate

a-D-Ribofuranose, 1,3,5-tribenzoate

1,3,5-Tri-O-Benzoyl-A-D-Ribofuranose

1,3,5-TRIBENZOYL-A-D-RIBOFURANOSE

1,3,5-Tri-O-Benzoyl-alpha-D-Ribofuranose(a-D-Ribofluranose-1,3,5-Tribenzoate)

1,3,5-tri-O-Benzoyl-alpha-D-Ri

1,3,5-tri-benzoyl-α-D-ribose

Clofarabine intermediate (III)

1,3,5-TRI-O-BENZOYL-ALPHA-D-RIBOFURANOSE 98%

1,3,5-Tribenzoate-α-D-Ribofuranose

1,3,5-Tribenzoyl-α-D-ribofuranose

1,3,5-Tri-O-benzoyl-α-D-ribofuranose ,98%

1,3,5-tribenzoate-a-D-Ribofuranose

1,3,5-Tribenzoyl-alpha-D-ribofuranose

1,3,5-Tri-O-Benzoyl-alpha-D-Ribofuranose Min98% C2

PR-002 1,3,5-Tri-O-benzoyl-D-ribofuranose

1,3,5-Tri-O-benzoyl-D-ribofuranose (Decitabine)

1,3,5-Tri- O -benzoyl-α-D-ribofuranoside

1,3,5-Tri-O-benzoyl-alpha-D-ribofuranose, 97% pale brown powder

1,3,5- three -O- benzoyl -a-D- furan ribos

[(2R,3S,4R,5R)-3,5-dibenzoyloxy-4-hydroxy-tetrahydrofuran-2-yl]methyl benzoate

[3,5-BIS(BENZOYLOXY)-4-HYDROXYOXOLAN-2-YL]METHYL BENZOATE

1,3,5-Bz-D-ribofuranose

Clofarabine Impurity 5

1,3,5-tribenzoyl - α - d-ribofuran

1，3，5-Tri-O-benzoyl-α-D-ribofuranose

1,3,5-Tri-O-benzoyl-D-ribofuranose USP/EP/BP

(2R,3S,4R)-3,5-bis(benzoyloxy)-4-hydroxyoxolan-2-yl]methyl benzoate

[(2R,5R)-3,5-dibenzoyloxy-4-hydroxyoxolan-2-yl]methyl benzoate

α-D-Ribofuranose 1,3,5-tribenzoate

α-D-Ribofuranose, 1,3,5-tribenzoate (6CI, 9CI, ACI)

1,3,5-tribenzoyl- α- D-furan ribose

1,3,5-Tri-O-benzoyesl-α-D-ribofuranose

α-<sc>D</sc>-Ribofuranose 1,3,5-tribenzoate

22224-41-5

222224-41-5

C26H22O8

Carbohydrate Synthesis

Specialty Synthesis

Monosaccharides

API intermediates

(intermediate of clofarabine)

Sugars, Carbohydrates & Glucosides

22224-41-5