PGP9.5
Description Source Background- Product Name
- PGP9.5
- CAS No.
- 1983173-20-1
- Chemical Name
- PGP9.5
- Synonyms
- UCHL;PARK5;NDGOA;SPG79;Uch-L1;PGP9.5;HEL-117;HEL-S-53;UCHL1 human;Human UCHL1/PGP9.5
- CBNumber
- CB71394521
- Formula Weight
- 0
- MOL File
- Mol file
PGP9.5 Property
- storage temp.
- -70°C
- form
- buffered aqueous solution
- biological source
- human
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- SRP5149
- Product name
- UCHL1, His tagged human
- Purity
- recombinant, expressed in <I>E. coli</I>, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
- Packaging
- 50 μg
- Price
- $360
- Updated
- 2025/07/31
- Product number
- SAB2501668
- Product name
- Anti-UCHL1 (C-terminal) antibody produced in goat
- Purity
- affinity isolated antibody, buffered aqueous solution
- Packaging
- 100 μg
- Price
- $586
- Updated
- 2025/07/31
- Product number
- SAB2501667
- Product name
- Anti-UCHL1 antibody produced in goat
- Purity
- affinity isolated antibody, buffered aqueous solution
- Packaging
- 100 μg
- Price
- $586
- Updated
- 2025/07/31
- Product number
- 359568
- Product name
- UCHL1
- Packaging
- 48Tests
- Price
- $588
- Updated
- 2021/12/16
- Product number
- 031320-PE
- Product name
- UCHL1
- Packaging
- 200ul
- Price
- $711
- Updated
- 2021/12/16
PGP9.5 Chemical Properties,Usage,Production
Uses
cell analysis
Biological Activity
UCHL1 is a member of the peptidase C12 family and a thiol protease th at hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin to generate the ubiquitin monomer. UCHL1 is expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in UCHL1 may be associated with Parkinson disease. The ligase and hydrolase activities of UCHL1 may play roles in proteasomal protein degradation, a process critical for neuronal health. Inhibition of UCHL1 in mouse hippocampal slices reduces normal synaptic function and long-term potentiation. PKA-CREB pathway mediates the effects of UCHL1 on Amyloid-beta-induced synaptic dysfunction and Uchl1 also reversed the inhibition of CREB phosphorylation induced by Amyloid-beta.
Description
UCHL1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 223 amino acids (1-223 a.a.) and having a molecular mass of 24.8 kDa (molecular weight on SDS-PAGE will appear higher).
Source
Escherichia Coli
Background
UCHL1 (PGP9.5) belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product (PGP9.5) is a neuron specific protein, structurally and immunologically distinct from neuron specific enolase. Human UCHL1 and UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein's resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons and nerve fibers at all levels of the central and peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia and leydig cells of the testis, in ova and in some cells of both the pregnant and non pregnant corpus luteum. A point mutation (I93M) in UCHL1 is implicated as the cause of Parkinson's disease in one kindred. On the other hand, a polymorphism (S18Y) in UCHL1 has been found to be associated with a reduced risk for Parkinson's disease. Furthermore, UCHL1 is associated with the Alzheimer's disease, and required for normal synaptic and cognitive function.
PGP9.5 Preparation Products And Raw materials
Raw materials
Preparation Products
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