CANTHARIDIC ACID

Product Name: CANTHARIDIC ACID
CAS No.: 28874-45-5
Chemical Name: CANTHARIDIC ACID
Synonyms: CANTHARIDIC ACID;CANTHARIDIC ACID DISODIUM SALT;Cantharidic acid, PP2A and PP1 inhibitor;Cantharidic Acid - CAS 28874-45-5 - Calbiochem;5'-3'2,3-DICARBOXY-2,3-DIMETHYL-1,4-EPOXYCYCLOHEXANE;EXO-1,6-DICARBOXY-ENDO-1,6-DIMETHYL-7-OXABICYLCO[2,2,1]HEPTANE;EXO-1,6-DICARBOXY-ENDO-1,6-DIMETHYL-7-OXABICYCLO[2,2,1]HEPTANE;7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, 2,3-dimethyl-, (1R,2S,3R,4S)-rel-
CBNumber: CB7141360
Molecular Formula: C10H14O5
Formula Weight: 214.22
MOL File: 28874-45-5.mol

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CANTHARIDIC ACID Property

Melting point:: 216-218℃
Boiling point:: 407.8±40.0 °C(Predicted)
Density: 1.359±0.06 g/cm3(Predicted)
storage temp.: +15C to +30C
solubility: Soluble in DMSO (100 mM) and in ethanol (25 mM, gentle warming)
form: White solid
pka: 3.70±0.40(Predicted)
color: white
InChI: InChI=1/C10H14O5/c1-9(7(11)12)5-3-4-6(15-5)10(9,2)8(13)14/h5-6H,3-4H2,1-2H3,(H,11,12)(H,13,14)/t5-,6+,9+,10-
InChIKey: NMTNUQBORQILRK-XCVPVQRUNA-N
SMILES: [C@@]12([H])O[C@@]([H])(CC1)[C@](C)(C(O)=O)[C@]2(C)C(O)=O |&1:0,3,7,12,r|

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Safety

Hazard Codes: Xi
Risk Statements: 38
Safety Statements: 22-36/37/39

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Hazard statements

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 210150
Product name: Cantharidic Acid
Purity: A potent inhibitor of protein phosphatase 2A (IC = 50 nM).
Packaging: 10mg
Price: $114
Updated: 2025/07/31

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CANTHARIDIC ACID Chemical Properties,Usage,Production

Uses

Cantharidic acid is a selective inhibitor for protein phosphatase 2 (PP2A) and protein phosphatase 1 (PP1). Cantharidic acid inhibits cell viability and arrest cell cycle at sub G1 phase, induces apoptosis in cells NPC-39 and HONE-1 through the upregulation of ERK1/2, p38, and JNK1/2 pathway[1].

Definition

ChEBI: A monoterpenoid with an epoxy-bridged bicyclic dicarboxylic acid structure, which acts as an inhibitor of protein phosphatases 1 and 2A.

Biological Activity

Cell permeable: no', 'Primary Target
PP2A', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 50 nM against protein phosphatase 2A

storage

Room temperature

References

[1] Chen YC, et al., Cantharidic acid induces apoptosis in human nasopharyngeal carcinoma cells through p38-mediated upregulation of caspase activation. Environ Toxicol. 2020 May;35(5):619-627. DOI:10.1002/tox.22897

CANTHARIDIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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CANTHARIDIC ACID Suppliers

China 15 Germany 1 Switzerland 2 United Kingdom 2 United States 7 Global 27

Guizhou Junzhitang Pharmaceutical Co., Ltd.

Tel: 0851-5872655
Fax: 0851-5872655
Email: 254624563@qq.com
Country: China
ProdList: 2
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shenzhen Botel Biotechnology Co. Ltd.

Tel: 13316949107 13316968096
Email: 1979313431@qq.com
Country: China
ProdList: 9564
Advantage: 58

Hefei Hirisun Pharmatech Co., Ltd

Tel: +8615056975894
Fax: 86-0551-62678551
Email: shawn@hirisunpharm.com
Country: CHINA
ProdList: 9911
Advantage: 58

Changzhou Xianglong Pharmaceutical Technology Co., LTD

Tel: 18661161657
Email: yaoxiangqiu2021@163.com
Country: China
ProdList: 9968
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 15921930842 15921930842
Email: yh-wang@univ-bio.com
Country: China
ProdList: 25006
Advantage: 58

QUALITY CONTROL SOLUTIONS LTD.

Tel: +86-0755-66853366 +86-13670046396
Email: export03@qcsrm.com
Country: China
ProdList: 24342
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 028-81700200 13308200041
Email: 2851167782@qq.com
Country: China
ProdList: 11146
Advantage: 58

Merck Millipore

Tel: 1-400-889-1988 400-889-1988
Email: bioscience@merckgroup.com
Country: China
ProdList: 6839
Advantage: 58

Enzo Biochem Inc

Tel: Enzo Biochem Inc. 13797054060
Email: Enzoname@qq.com
Country: China
ProdList: 6174
Advantage: 58

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5'-3'2,3-DICARBOXY-2,3-DIMETHYL-1,4-EPOXYCYCLOHEXANE

CANTHARIDIC ACID

CANTHARIDIC ACID DISODIUM SALT

EXO-1,6-DICARBOXY-ENDO-1,6-DIMETHYL-7-OXABICYCLO[2,2,1]HEPTANE

EXO-1,6-DICARBOXY-ENDO-1,6-DIMETHYL-7-OXABICYLCO[2,2,1]HEPTANE

Cantharidic Acid - CAS 28874-45-5 - Calbiochem

7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, 2,3-dimethyl-, (1R,2S,3R,4S)-rel-

Cantharidic acid, PP2A and PP1 inhibitor

28874-45-5

C8H10O5

Kinase/Phosphatase Biology

Serine/Threonine Phosphatase Inhibitors

Protein Phosphatase 1 (PP1)

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Phosphatase InhibitorsPost-Translational Modification

Phosphatase InhibitorsSerine/Threonine Kinase Biology

Protein Phosphatase 1 (PP1)Enzyme Inhibitors by Enzyme

Protein Phosphatase, PP1 and PP2A

Serine/Threonine Phosphatase Inhibitors

Cell Signaling and Neuroscience

Kinase/Phosphatase Biology

P to

Phosphorylation Analysis