4-Boc-1-piperazineacetic acid

Product Name: 4-Boc-1-piperazineacetic acid
CAS No.: 156478-71-6
Chemical Name: 4-Boc-1-piperazineacetic acid
Synonyms: 4-Boc-piperazineacetic Acid;4-Boc-1-piperazineacetic acid;BOC-4-CARBOXYMETHYLPIPERAZINE;2-(4-Boc-piperazino)acetic acid;4-N-BOC-1-Piperazineacetic acid;1-BOC-4-CARBOXYMETHYL PIPERAZINE;(1-BOC-PIPERAZIN-4-YL)ACETIC ACID;2-(4-Boc-1-piperazinyl)acetic acid;2-(1-Boc-piperazin-4-yl)-acetic aci;2-(1-BOC-PIPERAZIN-4-YL)-ACETIC ACID
CBNumber: CB7144710
Molecular Formula: C11H20N2O4
Formula Weight: 244.29
MOL File: 156478-71-6.mol

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4-Boc-1-piperazineacetic acid Property

Boiling point:: 365.5±37.0 °C(Predicted)
Density: 1.174
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 2.40±0.10(Predicted)
form: Solid
color: Off-white to gray
InChI: InChI=1S/C11H20N2O4/c1-11(2,3)17-10(16)13-6-4-12(5-7-13)8-9(14)15/h4-8H2,1-3H3,(H,14,15)
InChIKey: WZBHMXRBXXCEDD-UHFFFAOYSA-N
SMILES: N1(CC(O)=O)CCN(C(OC(C)(C)C)=O)CC1

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Safety

Hazard Codes: Xi
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B809875
Product name: 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)aceticAcid
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B809875
Product name: 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)aceticAcid
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Usbiological

Product number: 264137
Product name: 1-Boc-4-carboxymethyl piperazine
Packaging: 250mg
Price: $347
Updated: 2021/12/16

AK Scientific

Product number: C032
Product name: 1-Boc-4-carboxymethylpiperazine
Packaging: 1g
Price: $27
Updated: 2021/12/16

Matrix Scientific

Product number: 042385
Product name: Boc-(4-carboxymethyl)piperazine
Purity: 95+%
Packaging: 1g
Price: $39
Updated: 2021/12/16

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4-Boc-1-piperazineacetic acid Chemical Properties,Usage,Production

Uses

1-Boc-4-carboxymethyl piperazine is a PROTAC linker. 1-Boc-4-carboxymethyl piperazine can be used in the synthesis of PROTACs (e.g. PROTAC IRAK4 degrader-12 (HY-168586))[1].

Synthesis

209667-59-4

156478-71-6

b) General procedure for the synthesis of 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)acetic acid: to a solution of tert-butyl 4-(2-ethoxy-2-oxoethyl)piperazine-1-carboxylate (1.5 g, 5.51 mmol) in methanol (10 ml) was added an aqueous solution of sodium hydroxide (0.8 g, 22.0 mmol, 4 equiv). The reaction mixture was stirred at room temperature for 2 hours. Subsequently, the mixture was concentrated and extracted according to the method of Intermediate Example 5 (c). The solvent was removed by distillation to give the target product in 76% (1 g) yield. The product was characterized by LC-MS (ESI): calculated mass: 244.29; observed mass: 145.1 [M-Boc + H]+ (retention time: 0.102 min).

References

[1] Ling, et al. Preparation method for naphthoisoxazole compound. WO2024199146A1.WIPO, 2024-10-03.

4-Boc-1-piperazineacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Boc-1-piperazineacetic acid Suppliers

Canada 1 China 95 Germany 3 India 1 United Kingdom 3 United States 16 Global 119

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View Lastest Price from 4-Boc-1-piperazineacetic acid manufacturers

Career Henan Chemical Co

Product: 4-Boc-1-piperazineacetic acid 156478-71-6
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-10

Career Henan Chemical Co

Product: 4-Boc-1-piperazineacetic acid 156478-71-6
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-10

156478-71-6, 4-Boc-1-piperazineacetic acidRelated Search:

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BOC-4-CARBOXYMETHYLPIPERAZINE

1-BOC-4-CARBOXYMETHYL PIPERAZINE

4-[(1,1-DIMETHYLETHOXY)CARBONYL]-1-PIPERAZINEACETIC ACID

[4-(tert-butoxycarbonyl)piperazin-1-yl]acetic acid dihydrate

[4-(tert-butoxycarbonyl)piperazin-1-yl]aceticacid2H2O

2-(1-TERT-BUTOXYCARBONYL-PIPERAZIN-4-YL)-ACETIC ACID 2-HYDRATE

2-(1-Boc-piperazin-4-yl)-acetic acid dihydrate

2-(4-(tert-butoxycarbonyl)piperazin-1-yl)acetic acid

2-(1-BOC-PIPERAZIN-4-YL)-ACETIC ACID

[4-(tert-Butoxycarbonyl)-1-piperazinyl]acetic acid

4-Boc-1-piperazineacetic acid

2-(1-BOC-PIPERAZIN-4-YL)-ACETIC ACID 2 H2O

2-(1-TERT-BUTOXYCARBONYL-PIPERAZIN-4-YL)-ACETIC ACID 2 H2O

4-Carboxymethylpiperazine-1-carboxylic acid tert-butyl ester

(1-BOC-PIPERAZIN-4-YL)ACETIC ACID

2-(1-BOC-PIPERAZIN-4-YL)-ACETIC ACID X 2 H2O

2-(1-tert-Butoxycarbonyl-piperazin-4-yl)-acetic acid x 2 H2O

1-Piperazineacetic acid, 4-[(1,1-diMethylethoxy)carbonyl]-

[1-(tert-Butoxycarbonyl)piperazin-4-yl]acetic acid

2-(1-Boc-Piperazin-4-yl)-acetic acid hydrate

tert-Butyl 4-(carboxymethyl)piperazine-1-carboxylate

4-Boc-piperazineacetic Acid

2-(4-Boc-1-piperazinyl)acetic acid

2-(4-Boc-piperazino)acetic acid

2-(1-Boc-piperazin-4-yl)-acetic aci

2-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]acetic acid

4-N-BOC-1-Piperazineacetic acid

156478-71-6

C11H24N2O6

C11H20N2O42H2O

piperazines