8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione

Product Name: 8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
CAS No.: 90749-32-9
Chemical Name: 8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
Synonyms: 8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione;8-[2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl]-3,7-dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione;1H-Purine-2,6-dione, 8-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl]-3,9-dihydro-1-methyl-3-(2-methylpropyl)-
CBNumber: CB71455954
Molecular Formula: C29H36N6O2
Formula Weight: 500.64
MOL File: 90749-32-9.mol

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8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione Property

Melting point:: 202 °C(Solv: ethyl acetate (141-78-6))
Boiling point:: 692.5±65.0 °C(Predicted)
Density: 1.210±0.06 g/cm3(Predicted)
pka: 8.99±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0025844
Product name: LAPRAFYLLINE
Purity: 95.00%
Packaging: 5MG
Price: $502.54
Updated: 2021/12/16

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8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione Chemical Properties,Usage,Production

Uses

Laprafylline (S 9795), a xanthine derivative, is a bronchodilator. Laprafylline has potent anti-bronchoconstrictive effects, inhibiting action on mast cell degranulation and phosphodiesterase (PDE) activity (IC50 of 6 μM)[1].

in vivo

In male Sprague Dawley rats, Laprafylline (S 9795; 2.5-10mg/kg; iv) disappears rapidly from plasma with an elimination t_1/2 of 0.8 h, regardless of the dose administered. The volume of distribution is high (about 3 L/kg) but total clearance is also high (about 40 mL/min/kg).

References

[1] G Bianchi, et al. Kinetics and brain uptake of S 9795, a new xanthine derivate, in rats. Eur J Drug Metab Pharmacokinet. 1989 Jul-Sep;14(3):201-8. DOI:10.1007/BF03190100

8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione Suppliers

CHINA 4 United States 1 Global 5

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11973
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29423
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Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

90749-32-9, 8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dioneRelated Search:

8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione 2-(4-METHYL-1H-IMIDAZOL-2-YL)-ETHYLAMINE DIHYDROCHLORIDE Xanthine, 1,8-dimethyl-3-isobutyl- 1-methyl-3-propylxanthine 3-ISOBUTYL-1-METHYLXANTHINE Aminophylline ENPROFYLLINE

8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione

8-[2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl]-3,7-dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione

1H-Purine-2,6-dione, 8-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl]-3,9-dihydro-1-methyl-3-(2-methylpropyl)-

90749-32-9

C29H36N6O2