1-EBIO

ChemicalBook > CAS DataBase List > 1-EBIO

Product Name: 1-EBIO
CAS No.: 10045-45-1
Chemical Name: 1-EBIO
Synonyms: EBIO;1-EB10;1-EBIO;Einecs 233-148-1;1-EthylbenziMidazolinone;1-ETHYL-2-BENZIMIDAZOLINONE;1-ethylbenzimidazolin-2-one;1-ETHYL-2-BENZCMIDAZOLINONE;1-Ethyl-2-benzimidazolineone;3-ethyl-1H-benzimidazol-2-one
CBNumber: CB7146587
Molecular Formula: C9H10N2O
Formula Weight: 162.19
MOL File: 10045-45-1.mol

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1-EBIO Property

Melting point:: 118-120 °C(Solv: ethyl acetate (141-78-6))
Density: 1.161±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: ≥20mg/mL
form: powder
pka: 12.29±0.30(Predicted)
color: Crystalline
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0034
Product name: 1-EBIO
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $100
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0034
Product name: 1-EBIO
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $404
Updated: 2024/03/01

Cayman Chemical

Product number: 14575
Product name: 1-EBIO
Purity: ≥98%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 14575
Product name: 1-EBIO
Purity: ≥98%
Packaging: 10mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 14575
Product name: 1-EBIO
Purity: ≥98%
Packaging: 50mg
Price: $193
Updated: 2024/03/01

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1-EBIO Chemical Properties,Usage,Production

Description

1-EBIO is an activator of Ca2+-sensitive K+ channels (EC50 = 490 μM in T84 human carcinoma cells).This action is sensitive to the neurotoxin charybdotoxin (Ki = 3.5 nM). In mouse colonic epithelia, 1-EBIO also activates cAMP-sensitive K+ channels, a response this is inhibited by 293B.In this type of epithelium, but not mouse nasal epithelia, 1-EBIO activates both types of channels, resulting in large Cl- secretory currents.It also activates the human intermediate conductance Ca2+-activated K+ channel (EC50 = 74 μM).1-EBIO is currently used to study the role of these types of K+ channels in diverse physiological functions.

Uses

1-EBIO stimulates Cl- secretion in secretory epithelia through direct activation of clacium potassium channels.
1-EBIO was used to study the electrical activity modulated by Ca+2-activated K+ channels in rat central neurons. The effect of 1-EBIO on human intermediate conductance channels was studied.
The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients

Definition

ChEBI: 1-Ethyl-2-benzimidazolinone is a member of imidazoles.

Biological Activity

Activator of epithelial K Ca channels, stimulates a large and sustained trans-epithelial Cl - secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells.

storage

Room temperature

References

1) Adeagbo?et al.?(1999),?1-Ethyl-2-benzimidazolinone stimulates endothelial K(Ca) channels and nitric oxide formation in rat mesenteric vessels; Eur. J. Pharmacol.,?379?151 2) Orfila?et al. (2014),?Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation; Eur. J. Neurosci.,?40?3179 3) Allen?et al.?(2011),?SK2 channels are neuroprotective for ischemia-induced neuronal cell death; J. Cereb. Blood Flow Metab.,?31?2302 4) Muller?et al. (2012),?Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men; Stem Cell Rev.,?8?720 5) Fay?et al.?(2006),?SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes; Proc. Natl. Acad. Sci. USA,?103?17548

1-EBIO Preparation Products And Raw materials

Raw materials

Preparation Products

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1-EBIO Suppliers

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10045-45-1, 1-EBIORelated Search:

Oxatomide DROPERIDOL 1,3-DIHYDRO-1-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-2H-BENZIMIDAZOLE-2-ONE 4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE Domperidone Pimozide 1-ISOPROPENYL-2-BENZIMIDAZOLIDINONE 1-(3-Chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one 1H-Benzimidazole-1-propanoic acid, 2,3-dihydro-2-oxo- 1-EBIO SALOR-INT L202436-1EA ETHYL 3-(2,6-DICHLOROBENZYL)-2-OXO-2,3-DIHYDRO-1H-1,3-BENZIMIDAZOLE-1-CARBOXYLATE ETHYL 3-(2-METHYLBENZYL)-2-OXO-2,3-DIHYDRO-1H-1,3-BENZIMIDAZOLE-1-CARBOXYLATE ETHYL 3-(4-METHYLBENZYL)-2-OXO-2,3-DIHYDRO-1H-1,3-BENZIMIDAZOLE-1-CARBOXYLATE ETHYL 3-(3,4-DICHLOROBENZYL)-2-OXO-2,3-DIHYDRO-1H-1,3-BENZIMIDAZOLE-1-CARBOXYLATE ETHYL 3-(3-METHYLBENZYL)-2-OXO-2,3-DIHYDRO-1H-1,3-BENZIMIDAZOLE-1-CARBOXYLATE 3-BENZYL-2-OXO-2,3-DIHYDRO-BENZOIMIDAZOLE-1-CARBOXYLIC ACID ETHYL ESTER ETHYL 3-(2,4-DICHLOROBENZYL)-2-OXO-2,3-DIHYDRO-1H-1,3-BENZIMIDAZOLE-1-CARBOXYLATE

1-Ethyl-1H-benzimidazole-2(3H)-one

1-Ethyl-2,3-dihydro-1H-benzimidazole-2-one

EBIO

1-Ethyl-2-benzimidazolinone,98%

Einecs 233-148-1

1-EB10

1-ethyl-1,3-dihydro-2H-benzimidazol-2-one(SALTDATA: FREE)

1-EBIO, 1-Ethyl-2-benzimidazolinone

1-Ethyl-1H-benzo[d]iMidazol-2(3H)-one

1-EthylbenziMidazolinone

1-ETHYL-2-BENZIMIDAZOLINONE

1-ETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE

1-EBIO

1-Ethyl-2-benzimidazolineone

1-ethylbenzimidazolin-2-one

1-ETHYL-2-BENZCMIDAZOLINONE

2H-Benzimidazol-2-one,1-ethyl-1,3-dihydro-(9CI)

3-ethyl-1H-benzimidazol-2-one

2H-Benzimidazol-2-one, 1-ethyl-1,3-dihydro-

1-Ethyl-1,3-dihydro-2H-benzo[d]imidazol-2-one

10045-45-1

BENZIMIDAZOLE

Potassium channel

Ion Channels