1-EBIO
- Product Name
- 1-EBIO
- CAS No.
- 10045-45-1
- Chemical Name
- 1-EBIO
- Synonyms
- EBIO;1-EB10;1-EBIO;Einecs 233-148-1;1-EthylbenziMidazolinone;1-ETHYL-2-BENZIMIDAZOLINONE;1-ethylbenzimidazolin-2-one;1-ETHYL-2-BENZCMIDAZOLINONE;1-Ethyl-2-benzimidazolineone;3-ethyl-1H-benzimidazol-2-one
- CBNumber
- CB7146587
- Molecular Formula
- C9H10N2O
- Formula Weight
- 162.19
- MOL File
- 10045-45-1.mol
1-EBIO Property
- Melting point:
- 118-120 °C(Solv: ethyl acetate (141-78-6))
- Density
- 1.161±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO: ≥20mg/mL
- form
- powder
- pka
- 12.29±0.30(Predicted)
- color
- Crystalline
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML0034
- Product name
- 1-EBIO
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- SML0034
- Product name
- 1-EBIO
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $404
- Updated
- 2024/03/01
- Product number
- 14575
- Product name
- 1-EBIO
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 14575
- Product name
- 1-EBIO
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 14575
- Product name
- 1-EBIO
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $193
- Updated
- 2024/03/01
1-EBIO Chemical Properties,Usage,Production
Description
1-EBIO is an activator of Ca2+-sensitive K+ channels (EC50 = 490 μM in T84 human carcinoma cells).This action is sensitive to the neurotoxin charybdotoxin (Ki = 3.5 nM). In mouse colonic epithelia, 1-EBIO also activates cAMP-sensitive K+ channels, a response this is inhibited by 293B.In this type of epithelium, but not mouse nasal epithelia, 1-EBIO activates both types of channels, resulting in large Cl- secretory currents.It also activates the human intermediate conductance Ca2+-activated K+ channel (EC50 = 74 μM).1-EBIO is currently used to study the role of these types of K+ channels in diverse physiological functions.
Uses
1-EBIO stimulates Cl- secretion in secretory epithelia through direct activation of clacium potassium channels.
1-EBIO was used to study the electrical activity modulated by Ca+2-activated K+ channels in rat central neurons. The effect of 1-EBIO on human intermediate conductance channels was studied.
The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients
Definition
ChEBI: 1-Ethyl-2-benzimidazolinone is a member of imidazoles.
Biological Activity
Activator of epithelial K Ca channels, stimulates a large and sustained trans-epithelial Cl - secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells.
storage
Room temperature
References
1) Adeagbo?et al.?(1999),?1-Ethyl-2-benzimidazolinone stimulates endothelial K(Ca) channels and nitric oxide formation in rat mesenteric vessels; Eur. J. Pharmacol.,?379?151 2) Orfila?et al. (2014),?Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation; Eur. J. Neurosci.,?40?3179 3) Allen?et al.?(2011),?SK2 channels are neuroprotective for ischemia-induced neuronal cell death; J. Cereb. Blood Flow Metab.,?31?2302 4) Muller?et al. (2012),?Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men; Stem Cell Rev.,?8?720 5) Fay?et al.?(2006),?SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes; Proc. Natl. Acad. Sci. USA,?103?17548
1-EBIO Preparation Products And Raw materials
Raw materials
Preparation Products
1-EBIO Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15839
- Advantage
- 69
- Tel
- 86-21-60936353
- Fax
- 86-21-60936352
- Country
- China
- ProdList
- 335
- Advantage
- 58
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9459
- Advantage
- 58
- Tel
- 025-66099280 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19915
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7783
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41462
- Advantage
- 60
- Tel
- 17501653715
- xingui2022@126.com
- Country
- China
- ProdList
- 10021
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 0371-55900031 18137872243
- Fax
- QQ：2853979815
- 2853979815@qq.com
- Country
- China
- ProdList
- 10008
- Advantage
- 55
- Tel
- 021-37653318; 15221675714
- 515366396@qq.com
- Country
- China
- ProdList
- 2089
- Advantage
- 58
- Tel
- 021-61469567 13482353728
- Fax
- 021-61161605
- sales@fdc-chemical.com
- Country
- China
- ProdList
- 16474
- Advantage
- 58
- Tel
- 15623706179
- Fax
- -
- 2267948566@qq.com
- Country
- China
- ProdList
- 481
- Advantage
- 58
- Tel
- 400-8210725 18016230971
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 24969
- Advantage
- 58
- Tel
- Fax
- -
- jnyaoyan@163.com
- Country
- China
- ProdList
- 3069
- Advantage
- 58
- Tel
- 19822610310
- 3122922726@qq.com
- Country
- China
- ProdList
- 1346
- Advantage
- 58
- Tel
- meitaochem@126.com
- meitaochem@126.com
- Country
- China
- ProdList
- 19103
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9409
- Advantage
- 58
- Tel
- 13291169750 18151111370
- 1046215251@qq.com
- Country
- China
- ProdList
- 6723
- Advantage
- 58
- Tel
- 022-23989838 13810451150
- 44766350@qq.com
- Country
- China
- ProdList
- 1892
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0086-371-86658258
- factory@coreychem.com
- Country
- China
- ProdList
- 29811
- Advantage
- 58
- Tel
- 020-82000279 18988968278
- Fax
- QQ：3283937693
- sales@ubiochem.com
- Country
- China
- ProdList
- 4297
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- wulan@absin.cn
- Country
- China
- ProdList
- 24731
- Advantage
- 58
- Tel
- 0519-68985668 13685222090
- Fax
- qq735434464
- sales@kechem.cn
- Country
- China
- ProdList
- 26028
- Advantage
- 58
- Tel
- 029-81145920 13259709322
- Fax
- 029-88380327
- 1027@dideu.com
- Country
- China
- ProdList
- 10009
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44808
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 13348960310 13348960310
- 3003867561@qq.com
- Country
- China
- ProdList
- 10002
- Advantage
- 58
- Tel
- 021-51816796-820 13611835272
- Fax
- 021-5161 3951
- sales2@sunwaypharm.com
- Country
- China
- ProdList
- 44458
- Advantage
- 58
- Tel
- 18117455885
- qihongchem@163.com
- Country
- China
- ProdList
- 9323
- Advantage
- 58
- Tel
- 13774214275
- zhouzz@univ-bio.com
- Country
- China
- ProdList
- 24990
- Advantage
- 58
- Tel
- 400-8675577 19945755304
- sales@chemany.com
- Country
- China
- ProdList
- 9943
- Advantage
- 58
- Tel
- 18989489206
- hongxipharm@163.com
- Country
- China
- ProdList
- 4867
- Advantage
- 58
- Tel
- 18072846723; 18072846723
- caigou1@witofly.com
- Country
- China
- ProdList
- 2999
- Advantage
- 58
- Tel
- 18017383231
- 1849315414@qq.com
- Country
- China
- ProdList
- 828
- Advantage
- 58
- Tel
- 13621743886 13621743886
- 3366408901@qq.com
- Country
- China
- ProdList
- 4563
- Advantage
- 58
- Tel
- 010-50973130 17801761073
- Gsiyu@solarbio.com
- Country
- China
- ProdList
- 50749
- Advantage
- 58
- Tel
- 025-58851786 17714337195
- sales@tybiochem.com
- Country
- China
- ProdList
- 6813
- Advantage
- 58
- Tel
- 021-59167510 18117107507
- vip@med-life.cn
- Country
- China
- ProdList
- 4997
- Advantage
- 58
- Tel
- 028-85632863 18048500443
- Fax
- 028-85632863
- sales@micxy.com
- Country
- China
- ProdList
- 10474
- Advantage
- 58
- Tel
- +86-18521732826
- market@aladdin-e.com
- Country
- China
- ProdList
- 48461
- Advantage
- 58
- Tel
- 18024082417
- market@ubiochem.com
- Country
- China
- ProdList
- 9272
- Advantage
- 58
- Tel
- 15670369782
- 15670369782@163.com
- Country
- China
- ProdList
- 10051
- Advantage
- 58
- Tel
- 13757158499
- bolokobiotech@qq.com
- Country
- China
- ProdList
- 3543
- Advantage
- 58
- Tel
- +86-057181025280; +8617767106207
- Fax
- 0571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 49734
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 3988
- Advantage
- 58