Oxatomide
- Product Name
- Oxatomide
- CAS No.
- 60607-34-3
- Chemical Name
- Oxatomide
- Synonyms
- Tinse;Truxa;tinset;r35443;Dasten;Cobiona;Celtect;kw-4354;Cenacert;Fensedyl
- CBNumber
- CB3210840
- Molecular Formula
- C27H30N4O
- Formula Weight
- 426.55
- MOL File
- 60607-34-3.mol
Oxatomide Property
- Melting point:
- 153.60C
- Boiling point:
- 541.98°C (rough estimate)
- Density
- 1.1239 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- Refrigerator
- solubility
- DMSO: soluble
- form
- White solid.
- pka
- 12.20±0.30(Predicted)
- color
- white
- CAS DataBase Reference
- 60607-34-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- DE2276000
- Toxicity
- LD50 in guinea pigs, mice, rats (mg/kg): 320, >2560, >2560 orally; 23, 27, 30 i.v. (Richards)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- O9387
- Product name
- Oxatomide
- Purity
- ≥99%
- Packaging
- 10mg
- Price
- $324
- Updated
- 2024/03/01
- Product number
- O8107
- Product name
- Oxatomide
- Packaging
- 10mg
- Price
- $403
- Updated
- 2021/12/16
- Product number
- O845100
- Product name
- Oxatomide
- Packaging
- 50mg
- Price
- $495
- Updated
- 2021/12/16
- Product number
- CS-0081837
- Product name
- Oxatomide
- Purity
- 99.47%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-0081837
- Product name
- Oxatomide
- Purity
- 99.47%
- Packaging
- 10mg
- Price
- $200
- Updated
- 2021/12/16
Oxatomide Chemical Properties,Usage,Production
Chemical Properties
White Powder
Originator
Tinset,Janssen,W. Germany ,1981
Uses
Orally active anti-allergic agent; related structurally to cinnarizine and having a novel biphasic mode of action.
Uses
Inhibits the release and actions of leukotrienes
Definition
ChEBI: Oxatomide is a member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one substituted by a 3-[4-(diphenylmethyl)piperazin-1-yl]propyl group at position 1. It is an anti-allergic drug. It has a role as a geroprotector, a H1-receptor antagonist, an anti-allergic agent, an anti-inflammatory agent and a serotonergic antagonist. It is a N-alkylpiperazine, a member of benzimidazoles and a diarylmethane.
Manufacturing Process
A mixture of 53 parts of 1-(3chloropropyl)-2H-benzimidazol-2one, 5 parts of 1-(diphenylmethyl)piperazine, 6.4 parts of sodium bicarbonate and 200 parts of 4-methyl-2-pentanone is stirred and refluxed overnight with waterseparator. After cooling, water is added and the layers are separated. The 4methyl-2pentanone phase is dried, filtered and evaporated. The residue is purified by column-chromatography over silica gel using a mixture of trichloromethane and 5% of methanol as eluent. The pure fractions are collected and the eluent is evaporated. The oily residue is crystallized from a mixture of 2,2'-oxybispropane and a small amount of 2-propanol. The product is filtered off and dried, yielding 1-[3-[4-(diphenylmethyl)-1piperazinyl]propyl]-2H-benzimidazole-2-one; melting point 153.6°C.
Therapeutic Function
Antiallergic
Safety Profile
Poison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Experimental reproductive effects. Used to treat allergies and asthma. When heated to decomposition it emits toxic fumes of NOx.
Synthesis
Oxatomide is synthesized by alkylation of 1-diphenylmethylpiperazine with 1-(3-chloropropyl)-1,3-dihydro-2Hbenzimidazol- 2-one in the presence of Na2CO3 . In addition to its histamine H1 receptor antagonistic effect, oxatomide may have mast-cell stabilizing activities .
Oxatomide Preparation Products And Raw materials
Raw materials
Preparation Products
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