ChemicalBook > CAS DataBase List > Oxatomide

Oxatomide

Product Name
Oxatomide
CAS No.
60607-34-3
Chemical Name
Oxatomide
Synonyms
Tinse;Truxa;tinset;r35443;Dasten;Cobiona;Celtect;kw-4354;Cenacert;Fensedyl
CBNumber
CB3210840
Molecular Formula
C27H30N4O
Formula Weight
426.55
MOL File
60607-34-3.mol
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Oxatomide Property

Melting point:
153.60C
Boiling point:
541.98°C (rough estimate)
Density 
1.1239 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Refrigerator
solubility 
DMSO: soluble
form 
White solid.
pka
12.20±0.30(Predicted)
color 
white
CAS DataBase Reference
60607-34-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
DE2276000
Toxicity
LD50 in guinea pigs, mice, rats (mg/kg): 320, >2560, >2560 orally; 23, 27, 30 i.v. (Richards)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
O9387
Product name
Oxatomide
Purity
≥99%
Packaging
10mg
Price
$324
Updated
2024/03/01
TRC
Product number
O845100
Product name
Oxatomide
Packaging
50mg
Price
$495
Updated
2021/12/16
Usbiological
Product number
O8107
Product name
Oxatomide
Packaging
10mg
Price
$403
Updated
2021/12/16
ChemScene
Product number
CS-0081837
Product name
Oxatomide
Purity
99.47%
Packaging
50mg
Price
$600
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
12818
Product name
Oxatomide
Packaging
10mg
Price
$860
Updated
2021/12/16
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Oxatomide Chemical Properties,Usage,Production

Chemical Properties

White Powder

Originator

Tinset,Janssen,W. Germany ,1981

Uses

Orally active anti-allergic agent; related structurally to cinnarizine and having a novel biphasic mode of action.

Uses

Inhibits the release and actions of leukotrienes

Definition

ChEBI: Oxatomide is a member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one substituted by a 3-[4-(diphenylmethyl)piperazin-1-yl]propyl group at position 1. It is an anti-allergic drug. It has a role as a geroprotector, a H1-receptor antagonist, an anti-allergic agent, an anti-inflammatory agent and a serotonergic antagonist. It is a N-alkylpiperazine, a member of benzimidazoles and a diarylmethane.

Manufacturing Process

A mixture of 53 parts of 1-(3chloropropyl)-2H-benzimidazol-2one, 5 parts of 1-(diphenylmethyl)piperazine, 6.4 parts of sodium bicarbonate and 200 parts of 4-methyl-2-pentanone is stirred and refluxed overnight with waterseparator. After cooling, water is added and the layers are separated. The 4methyl-2pentanone phase is dried, filtered and evaporated. The residue is purified by column-chromatography over silica gel using a mixture of trichloromethane and 5% of methanol as eluent. The pure fractions are collected and the eluent is evaporated. The oily residue is crystallized from a mixture of 2,2'-oxybispropane and a small amount of 2-propanol. The product is filtered off and dried, yielding 1-[3-[4-(diphenylmethyl)-1piperazinyl]propyl]-2H-benzimidazole-2-one; melting point 153.6°C.

Therapeutic Function

Antiallergic

Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Experimental reproductive effects. Used to treat allergies and asthma. When heated to decomposition it emits toxic fumes of NOx.

Synthesis

Oxatomide is synthesized by alkylation of 1-diphenylmethylpiperazine with 1-(3-chloropropyl)-1,3-dihydro-2Hbenzimidazol- 2-one in the presence of Na2CO3 . In addition to its histamine H1 receptor antagonistic effect, oxatomide may have mast-cell stabilizing activities .

Oxatomide Preparation Products And Raw materials

Raw materials

Xylene Benzimidazole Potassium iodide Triethylamine 1-BENZHYDRYLPIPERAZINE 4-Methyl-2-pentanone 1-Bromo-3-chloropropane o-Phenylenediamine

Preparation Products

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60607-34-3, OxatomideRelated Search:

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  • OXATOMIDE
  • oxatomida
  • r35443
  • tinset
  • 1-[3-[4-(DIPHENYLMETHYL)-1-PIPERAZINYL]PROPYL]-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE
  • Celtect
  • Cobiona
  • Dasten
  • Tinse
  • 1-[3-[4-(Diphmylmethyl)-1-piperazirlyI]propyl]-1，3-dihydro-2H-benzimidazol-2one
  • Cenacert
  • Fensedyl
  • KW-4354：McN-JR-35443
  • Truxa
  • 3-[3-[4-(diphenylmethyl)-1-piperazinyl]propyl]-1H-benzimidazol-2-one
  • 1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-1,3-dihydro-2h-benzimidazol-2
  • 1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-2-benzimidazolinone
  • 1,3-dihydro-1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-2h-benzimidazol-2-on
  • 2h-benzimidazol-2-one,1,3-dihydro-1-(3-(4-(diphenylmethyl)-1-piperazinyl)propy
  • kw-4354
  • oxatimide
  • 3-[3-[4-(Diphenylmethyl)piperazino]propyl]-1H-benzoimidazole-2(3H)-one
  • OxatoMide API
  • 1-(3-(4-Benzhydrylpiperazin-1-yl)propyl)-1H-benzo[d]iMidazol-2(3H)-one
  • 2H-Benzimidazol-2-one, 1-[3-[4-(diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-
  • Oxatomide USP/EP/BP
  • OxatomideQ: What is Oxatomide Q: What is the CAS Number of Oxatomide Q: What is the storage condition of Oxatomide Q: What are the applications of Oxatomide
  • 1-(3-(4-Benzhydrylpiperazin-1-yl)propyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
  • Oxatomide Anyhdrous
  • 1-{3-[4-(diphenylmethyl)piperazin-1-yl]propyl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
  • Zinc Acexamate Impurity 6
  • 60607-34-3
  • C27H30NO3
  • C27H30N4O
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Immune Cell Signaling and Blood
  • Immune System Regulation
  • Immunomodulators and Antibiotics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals