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2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID

Product Name
2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID
CAS No.
915030-08-9
Chemical Name
2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID
Synonyms
4-Carboxy-2-(trifluoromethyl)-1,3-thiazole;2-(trifluoroMethyl)thiazole-4-carboxylic acid;4-Thiazolecarboxylic acid, 2-(trifluoromethyl)-;2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID;Name 2-(Trifluoromethyl)-1,3-thiazole-4-carboxylic acid
CBNumber
CB71466439
Molecular Formula
C5H2F3NO2S
Formula Weight
197.14
MOL File
915030-08-9.mol
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2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID Property

Melting point:
179-184°C
Boiling point:
224.6±40.0 °C(Predicted)
Density 
1.668±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
solid
pka
3.09±0.10(Predicted)
color 
Gray
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2934100090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
775169
Product name
2-(Trifluoromethyl)thiazole-4-carboxylic acid
Purity
95% (GC)
Packaging
500mg
Price
$81.6
Updated
2023/06/20
TRC
Product number
T797208
Product name
2-(Trifluoromethyl)thiazole-4-carboxylic acid
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
T797208
Product name
2-(Trifluoromethyl)thiazole-4-carboxylic acid
Packaging
50mg
Price
$60
Updated
2021/12/16
TRC
Product number
T797208
Product name
2-(Trifluoromethyl)thiazole-4-carboxylic acid
Packaging
100mg
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
8H21-3-09
Product name
2-(Trifluoromethyl)-1,3-thiazole-4-carboxylic acid
Packaging
1g
Price
$77
Updated
2021/12/16
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2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

133046-46-5

915030-08-9

The general procedure for the synthesis of 2-(trifluoromethyl)-1,3-thiazole-4-carboxylic acid from ethyl 2-(trifluoromethyl)thiazole-4-carboxylate was as follows: ethyl 2-(trifluoromethyl)thiazole-4-carboxylate (400 mg, 1.176 mmol) was dissolved in a solvent mixture of THF/methanol (9:1, v/v), and a 1 M aqueous lithium hydroxide (3.55 mL, 3.55 mmol). The reaction mixture was stirred at room temperature for 1 h, followed by adjusting the pH with dilute hydrochloric acid to 2. The reaction mixture was extracted three times with ethyl acetate, the organic phases were combined, dried over anhydrous sodium sulfate and concentrated to dryness under reduced pressure. The product yield was 93% and mass spectrometric detection showed m/z [M+H]+ of 197.1.

References

[1] Patent: WO2011/51540, 2011, A1. Location in patent: Page/Page column 140-141
[2] Patent: WO2006/122200, 2006, A1. Location in patent: Page/Page column 44
[3] Patent: US2009/131431, 2009, A1. Location in patent: Page/Page column 148
[4] Patent: WO2007/36733, 2007, A1. Location in patent: Page/Page column 222-223
[5] Patent: WO2009/147188, 2009, A1. Location in patent: Page/Page column 110

2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID Suppliers

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View Lastest Price from 2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co
Product
Name 2-(Trifluoromethyl)-1,3-thiazole-4-carboxylic acid 915030-08-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-09

915030-08-9, 2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBOXYLIC ACIDRelated Search:


  • 2-(TRIFLUOROMETHYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID
  • 2-(trifluoroMethyl)thiazole-4-carboxylic acid
  • 4-Carboxy-2-(trifluoromethyl)-1,3-thiazole
  • Name 2-(Trifluoromethyl)-1,3-thiazole-4-carboxylic acid
  • 4-Thiazolecarboxylic acid, 2-(trifluoromethyl)-
  • 915030-08-9
  • C5H2F3NO2S
  • Carboxylic Acids
  • Thiazoles, Isothiazoles & Benzothiazoles
  • Thiazole series
  • Carboxylic Acids
  • Thiazoles, Isothiazoles &Benzothiazoles