(2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol
- Product Name
- (2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol
- CAS No.
- 289893-25-0
- Chemical Name
- (2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol
- Synonyms
- Pefcalcitol;Amrioclomol;arimoclomol;BRX-220 free base;(2R-)Arimoclomol NEW;(2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol;3-Pyridinecarboximidoyl chloride, N-[(2R)-2-hydroxy-3-(1-piperidinyl)propoxy]-, 1-oxide;aggregation,Heat shock proteins,HSP,co-inducer,system,BRX220,motor,Arimoclomol,inhibit,ubiquitin,BRX 220,neurons,misfolded,proteasome,BRX-220,protein,assemblies,clearance,Inhibitor
- CBNumber
- CB71480024
- Molecular Formula
- C14H20ClN3O3
- Formula Weight
- 313.78
- MOL File
- 289893-25-0.mol
(2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol Property
- Melting point:
- 93 - 95o C
- Boiling point:
- 539.2±60.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 14.03±0.20(Predicted)
- color
- White to Off-White
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H261In contact with water releases flammable gas
- Precautionary statements
-
P223Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P231+P232Handle under inert gas. Protect from moisture.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P335+P334Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P370+P378In case of fire: Use … for extinction.
P402+P404Store in a dry place. Store in a closed container.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A771278
- Product name
- Arimoclomol
- Packaging
- 1mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FA30834
- Product name
- (2R-)Arimoclomol NEW
- Packaging
- 5mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- FA30834
- Product name
- (2R-)Arimoclomol NEW
- Packaging
- 10mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- FA30834
- Product name
- (2R-)Arimoclomol NEW
- Packaging
- 25mg
- Price
- $475
- Updated
- 2021/12/16
- Product number
- API0007198
- Product name
- AMRIOCLOMOL
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $2732.5
- Updated
- 2021/12/16
(2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol Chemical Properties,Usage,Production
Uses
Arimoclomol is a co-inducer of HSP that acts through heat shock factor 1 (HSF1) in cells undergoing cellular stress. Has therapeutic potential in motor neuron degenerative diseases. Potential treatment for liposomal storage disorders, such as Niemann-Pick disease type C.